pulmonary disease – Page 35 – Communicable Diseases Research

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

NVX-CoV2373 백신은 SARS-CoV-2 공격으로부터 사이노몰구스 마카크 상부 및 하부 기도를 보호합니다.

Article

Published on 2020-11-252022-09-12
Journal: Vaccine [Category] SARS, 진단,

Moving singing for lung health online in response to COVID-19: experience from a randomised controlled trial

COVID-19에 대응하여 폐 건강을 위한 온라인 노래 이동: 무작위 대조 시험의 경험

Randomized Controlled Trial

Published on 2020-11-252022-08-09
Journal: BMJ Open Respiratory Research [Category] 임상,

[키워드] ABC ABC scale points actigraphy activity adaptation Anxiety Anxiety Disorder assessment Attendance balance balance confidence benefit biopsychosocial benefits blind breathlessness chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) complementary medicine conducted confidence controls COPD COPD Assessment Test score COVID-19-related physical distancing COVID-19-related physical distancing measures Depression digital barrier digital barriers digital facilitator digital facilitators disease Dyspnoea exercise experience face-to-face sessions facilitator facilitators finding FIVE form Generalised anxiety disorder Generalised Anxiety Disorder-7 Health help identify improvement Improving include key consideration key considerations life long-term respiratory conditions lung Lung disease Measures Medical Research Council nine obstructive pulmonary disease online delivery online group singing online sessions participant Participation participation in SLH people with COPD PHQ-9 physical activity physical distancing measures Pilot quantitative data Pilot quantitative outcome Pilot quantitative outcomes pilot study postmeasure postmeasures premeasure premeasures Proactive pulmonary disease Quality of life randomised controlled randomised controlled trial reducing reported Research respiratory Result semistructured interview semistructured interviews setup Seven singing singing group singing groups suggested survey Test thematic analysis Treatment Trial usual care
[DOI] 10.1136/bmjresp-2020-000737 PMC 바로가기 [Article Type] Randomized Controlled Trial

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

THE JOURNAL OF GERONTOLOGY: Medical Sciences

Published on 2020-11-202022-10-30
Journal: The Journals of Gerontology Series A: Biological S [Category] COVID-19, MERS, SARS,

[키워드] adjusted age association Asthma Atrial fibrillation Baseline assessment chronic chronic obstructive Cohort common Community Comorbidities Comorbidity Coronary heart disease COVID-19 COVID-19 hospitalization COVID-19 patient death Dementia demographic Depression diabetes diagnose died England Epidemiology hospital hospital discharge Hospitalized hospitalized COVID-19 hypertension independent risk factor Inpatient Inpatients Kidney disease laboratory-confirmed Logistic men men and women morbidity Mortality Older older population participant Pneumonia preexisting comorbidity Prevent pulmonary disease Result risk factor severe COVID-19 infections Sex statistically significant Support tested type 2 diabete type 2 diabetes UK biobank women
[DOI] 10.1093/gerona/glaa183 PMC 바로가기 [Article Type] THE JOURNAL OF GERONTOLOGY: Medical Sciences

Association of Statin Use With the In-Hospital Outcomes of 2019-Coronavirus Disease Patients: A Retrospective Study

Medicine

Published on 2020-11-172022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 1:1 95% CI acute respiratory distress added adjusted Admission age alleviate Analysis analyzed ARDS association blood lipids Brain Care Case series cholesterol chronic obstructive Clinical outcome Coagulation Cohort collected Comorbidities confounders coronavirus disease COVID-19 COVID-19 patient Cox regression model demographic diabete enrolled excluded Gender help hospital ICU Immunity In-hospital Inflammation intensive care investigated Kaplan-Meier survival curve Laboratory lipoprotein cholesterol lower risk medication Mortality multivariate Cox model outcome Patient patients with COVID-19 peptide Pneumonia procalcitonin protective effect pulmonary disease remained retrospective Retrospective analysis risk sensitivity analysis statin statistically significant survival syndrome therapy Treatment Triglyceride Wuhan, China
[DOI] 10.3389/fmed.2020.584870 PMC 바로가기 [Article Type] Medicine

Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review

COVID-19에 감염된 환자의 중증도 및 사망률에 대한 예후 인자: 체계적인 검토

Research Article

Published on 2020-11-172022-08-13
Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, MERS, SARS,

[키워드] abdominal pain age albumin anorexia applied Arterial hypertension arthralgia aspartate Aspartate aminotransferase AST Bilirubin Blood blood bilirubin blood cell blood platelet Blood urea nitrogen BNP C-reactive protein Cancer Cardiac arrhythmia cardiovascular disease Care CENTRAL Cerebrovascular disease certainty Chronic kidney disease chronic obstructive chronic obstructive pulmonary disease clinician Comorbidities conducted Controlled controlled trials creatine creatine kinase creatinine CRP D-dimer data extraction database Decision-making decrease Dementia demographic Demographic factors develop diabetes disease severity dyslipidemia Dyspnea eligibility erythrocyte sedimentation erythrocyte sedimentation rate Evidence examined facilitate Factor fatigue Fever GRADE haemoptysis help hypertension Hypoxemia Identified identify IL-6 IMPROVE infected with COVID-19 Infectious disease information interleukin-6 Kidney disease Laboratory Lactate lactate dehydrogenase LDH low blood pressure lymphocyte Lymphocyte count Male sex management meta-analyses Meta-analysis moderate Mortality multivariable prognostic model multivariable prognostic models myalgia myocardial injury neutrophil neutrophil count nitrogen obstructive pulmonary disease Organ failure outcome outcomes Patient patients with COVID-19 peptide performed Physical examination plasma Platelet count pleural effusion procalcitonin prognostic Prognostic factor Prognostic factors PROSPERO pulmonary disease radiological registration number researcher Respiratory failure Result Risk of bias SARS-CoV-2 screened sedimentation rate sequential organ failure assessment score severe disease severity smoking SOFA score Study design systematic review Tachycardia tachypnea urea variable WBC white
[DOI] 10.1371/journal.pone.0241955 PMC 바로가기 [Article Type] Research Article

Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank

UK Biobank의 코로나19 환자의 임상적, 지역적, 유전적 특성

Research Article

Published on 2020-11-172022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 95% CI adjusted adjusted relative risk Adjusting analyzed angiotensin angiotensin converting enzyme association baseline black Black race Blood blood type Blood types Characteristics chronic obstructive chronic obstructive pulmonary disease clinical Clinical risk factors Clustering Comorbidities conducted coronavirus disease Coronavirus disease 2019 Depression Deprivation determined by discrimination disease severity Effect enzyme Evidence Factor Factors feature Genetic genetic factors Genetic variant genetic variants group heart disease higher risk include increase in increased risk indication individual individuals information inhibitor ischemic heart disease Laboratory limitation Local loci longitudinal cohort study main outcome measure Meta-analysis obstructive pulmonary disease Odds ratio participant Participants Patient patients with comorbidity Poisson regression positive positive status Positive test prospective cohort study provided pulmonary disease Racial recent recruited reduced Relative risk Research Result risk risk factor robust rs8176719 significantly increased Standard deviation test results tested UK biobank United Kingdom white zone
[DOI] 10.1371/journal.pone.0241264 PMC 바로가기 [Article Type] Research Article

Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development

Article

Published on 2020-11-132022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, SARS,

[키워드] accompanied Activation acute respiratory syndrome adverse effect AEC Affect alveolar alveolar organoid angiotensin-converting enzyme 2 Cell childhood clade cofactor coronavirus demonstrated development developmental dPM2.5 EMT epithelial Evidence explain exposure to expression Extracellular fibrosis had no Human human pluripotent stem cells in vitro incidence infancy Inflammation investigated lack lung Lung function matter mechanism multicellular nicotinamide adenine dinucleotide Organoid Particulate phosphate platform pluripotent stem cell prenatal promoted protease Protein provided pulmonary disease receptor reduced Research SARS-CoV-2 serine 2 Signaling significantly STEM susceptibility target cells Toxicity toxin transition transmembrane treated Treatment unique upregulated upregulation virus
[DOI] 10.3390/ijerph17228410 PMC 바로가기 [Article Type] Article

The effect of surfactant on clinical outcome of patients with COVID-19 under mechanical ventilation: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-11-112022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 6 hour accompany acute respiratory distress syndrome addition adjusted Administered age anticipated approach ARDS Assessing auxiliary Bacterial blinded Care Clinical outcome control group COVID-10 COVID-19 COVID-19 patient discharge disease dissemination dose doses ECMO element etiology Existence extracorporeal membrane oxygenation Face mask Healthcare provider hospital hospital discharge rate Randomised controlled trial Hospital length of stay ICU information intervention group intubation investigator Iran less lung involvement mechanical ventilation moderate Mortality much lower number objective outcome P/F ratio parallel group participant Patient patient mortality patients with COVID-19 Pneumonia protocol pulmonary disease pulmonary involvement random randomisation randomised randomised controlled trial receive Registration researchers Sample size SARS-CoV-2 second dose sequence severe ARDS status Study protocol surfactant Tehran the patient time Trial ventilator Version Volume website written consent
[DOI] 10.1186/s13063-020-04815-z PMC 바로가기 [Article Type] Letter

A Scientific Rationale for Using Cystic Fibrosis Transmembrane Conductance Regulator Therapeutics in COVID-19 Patients

Physiology

Published on 2020-11-042022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions

병원 내 COVID-19 사망률 예측인자: 연령, 성별 및 건강 상태에 따른 차이를 탐색하는 포괄적인 체계적인 검토 및 메타 분석

Research Article

Published on 2020-11-032022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] addition age albumin ALT applied AST Bilirubin C-reactive protein cardiac troponin Cardiac troponin I clinical condition clinical conditions Comorbidities Comorbidity Concentration conditions conducted confirmed COVID-19 patients COVID-19 COVID-19 mortality COVID-19 patient creatinine Critical database deaths diabete diabetes Dyspnoea effect size Factor ferritin followed by Haemoglobin Health health condition heterogeneity hospital hypertension In-hospital in-hospital mortality increased mortality interleukin-6 Kidney disease laboratory parameter Laboratory parameters LDH malignancy meta-analyses Meta-analysis meta-regression Mortality nitrogen obesity objective Odds ratio older patient older patients Patient patients Platelet Platelet count populations predictor predictors prognostic effect pulmonary disease random-effects meta-analyses registration number Result risk Sex smoking Subgroup analyses subgroup analysis systematic review the mean the MEDLINE total bilirubin troponin I urea urea nitrogen variable Web of Science
[DOI] 10.1371/journal.pone.0241742 PMC 바로가기 [Article Type] Research Article