Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumoniaControlled Clinical Trial Published on 2021-04-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 임상, 치료법, [키워드] adjusted adjusted hazard ratio Admission Anakinra anti-inflammatory treatment Anticoagulants Antiviral baseline cohort study Combination coronavirus disease covariates COVID-19 COVID-19 pneumonia Cox model Cytokine storm early treatment Efficacy Efficacy and safety evaluated glucocorticoid Glucocorticoids High dose Hydroxychloroquine IL-1 Inflammatory response intravenous intravenous methylprednisolone Mortality Patient patients patients with COVID-19 performed Pneumonia receive receiving reduced retrospective Severe COVID-19 pneumonia single-center Standard of care survival Tocilizumab Treatment were used [DOI] 10.1016/j.jaci.2021.01.024 PMC 바로가기 [Article Type] Controlled Clinical Trial
Early clinical factors predicting the development of critical disease in Japanese patients with COVID-19: A single-center, retrospective, observational study일본 COVID-19 환자의 중병 발병을 예측하는 초기 임상 요인: 단일 센터, 후향적, 관찰 연구Observational Study Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 임상, [키워드] Admission Analysis Asymptomatic characteristic clinical factor clinical factors Comorbidity coronavirus coronavirus disease coronavirus disease-2019 COVID-19 CoVs Cox proportional hazard Cox proportional hazards analysis Critical Critical disease cutoff value disease Disease progression EGFR elevated elevated lactate dehydrogenase enrolled evaluated excluded Factor filtration rate glomerular filtration rate hospital Hospitalized Japanese Japanese patients Laboratory laboratory finding laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Logistic lymphocytopenia male mechanical ventilation median age median time Mild mild to moderate moderate not significant Patient patients with COVID-19 Pediatric patients progression receiver operating characteristic retrospective risk factor Risk factors significantly single-center statin symptom onset [DOI] 10.1002/jmv.26599 PMC 바로가기 [Article Type] Observational Study
Bamlanivimab for treatment of COVID-19 in solid organ transplant recipients: Early single-center experience고형장기 이식 환자의 코로나19 치료를 위한 밤라니비맙: 초기 단일 센터 경험Article Published on 2021-04-012022-09-12 Journal: Clinical transplantation [Category] 진단, [키워드] bamlanivimab COVID-19 single-center solid organ transplant Treatment [DOI] 10.1111/ctr.14245 PMC 바로가기 [Article Type] Article
Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital3차 의뢰 병원에 입원한 COVID-19 환자의 비타민 D 25OH 결핍Article Published on 2021-04-012022-09-11 Journal: Clinical nutrition (Edinburgh, Scotland) [Category] MERS, SARS, 바이오마커, [키워드] 95% CI adult COVID-19 patient association clinical feature Clinical outcome clinical outcomes cohort study confounders coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient deficiency determine disease disease severity enrolled hospital Hospital admission Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients in-hospital mortality Intervention Italian logarithmic scale marker moderate Mortality Odds ratio outcome outcomes positive Prevalence prevalent protective role raised Serum level severe COVID-19 patients severe deficiency single-center tertiary referral hospital trials variables Vitamin Vitamin D Vitamin D 25OH. vitamin D deficiency vitamin D insufficiency vitamin D levels were assessed with COVID-19 [DOI] 10.1016/j.clnu.2020.10.055 PMC 바로가기 [Article Type] Article
Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers커뮤니티 기반 테스트 센터의 진료 현장에서 두 가지 상용 SARS-CoV-2 항원 검출 빠른 테스트의 진단 정확도Research Article Published on 2021-03-312022-08-13 Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] (Abbott 95% CI Abbott Accuracy Ag-RDT Ag-RDTs best Characteristics criteria diagnostic Diagnostic accuracy diagnostic tests diagnostic value enrolled False positive Fever independent individual individuals Laboratory less Lower nasopharyngeal swabs objective PanBio participant Participants Patient performed point of care positive positive RT-PCR presenting Rapid Rapid diagnostic test Rapid test Result Roche RT-PCR SARS-CoV-2 SD Biosensor sensitivity single-center specificity Standard Q Ag-RDT structures Symptom symptom onset symptomatic Test Testing typical symptom typical symptoms was obtained WHO criteria yielding [DOI] 10.1371/journal.pone.0248921 PMC 바로가기 [Article Type] Research Article
Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis면역 요법은 SARS-CoV-2 감염으로부터 암 환자를 보호할 수 있습니다: 단일 센터 후향적 분석Research Published on 2021-03-312022-09-12 Journal: Journal of Translational Medicine [Category] SARS, 진단, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Campania Cancer cancer patient Cancer patients Chemotherapy Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection effect of treatment Ensuring examined frailty Gender global pandemic group healthcare providers Healthcare system Healthcare systems ICIs IgG IgM Immune checkpoint inhibitors Immunotherapy IRCCS Logistic mandatory matching Naple Naples no statistically significant difference Odds ratio oncology Patient Performing positive Preliminary data propensity score matching proportion PROTECT protective factor resulting Retrospective analysis SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 seropositivity score Seropositivity severe acute respiratory syndrome Coronavirus significantly single-center statistically significant difference subject treated Treatment Tumor tumor stage unique [DOI] 10.1186/s12967-021-02798-2 PMC 바로가기 [Article Type] Research
Application of quantitative lung ultrasound instead of CT for monitoring COVID-19 pneumonia in pregnant women: a single-center retrospective study임산부의 코로나19 폐렴 모니터링에 CT 대신 정량적 폐초음파 적용: 단일기관 후향적 연구Research Article Published on 2021-03-262022-09-01 Journal: BMC Pregnancy and Childbirth [Category] SARS, 진단, 치료기술, [키워드] Admission alternative analyzed application average calculate Chest CT clinical clinically Computed tomography Consistency consolidation correlation COVID-19 COVID-19 pneumonia cured discharge evaluated fetus Follow-up Hospitalization Infection ionizing radiation irregular pleural line lung lung involvement Lung ultrasound Patient pleural effusion Pneumonia pregnant Pregnant woman pregnant women PROTECT Quantitative Radiation Result Retrospective study risk single-center subpleural tomography with COVID-19 [DOI] 10.1186/s12884-021-03728-2 PMC 바로가기 [Article Type] Research Article
Clinical Features and Risk Factors for In-Hospital Mortality From COVID-19 Infection at a Tertiary Care Medical Center, at the Onset of the US COVID-19 PandemicOriginal Research Published on 2021-03-242022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, [키워드] Admission adverse outcomes age albumin AST benefit Care center clinical Clinical research clinical risk factor Cohort collected comorbid condition Comorbidity conducted congestive heart failure COVID-19 death Dementia Detroit Diagnosis died Factor fatal COVID-19 Fatality rate greater help hospital Hospital mortality hospitalized patients identify in-hospital mortality independent index Infection infections information initial Inpatient Intervention Laboratory laboratory biomarker laboratory data lymphocytopenia male malignancy management marker mitigate Mortality multivariable analysis Nasopharyngeal swab obesity observation Older Older age Onset pandemic Patient patients died patients with COVID-19 positive Primary outcome qSOFA remained retrospective cohort study risk factor RT-PCR significantly single-center Tertiary understanding vital signs WBC with COVID-19 [DOI] 10.1177/08850666211001799 PMC 바로가기 [Article Type] Original Research
Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study진통 통각 지수를 사용한 심박수 변동성 모니터링이 COVID-19 중증 환자의 질병 중증도 및 사망률의 예측인자입니까? 파일럿 연구Observational Study Published on 2021-03-242022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, [키워드] Analysis ANIm anti-inflammatory response autonomic Autonomic nervous system autonomous conducted correlated COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients date of death death Depletion discharge domain energy Frequency heart rate HRV Hypothesis IL-6 IL-6 level IL-6 levels Illness severity intensive care unit interval limit management material mechanical ventilation MONITOR mortalities Mortality nervous system non-survivor normalized on mechanical ventilation parameter parasympathetic parasympathetic system Patient pilot study predicted Predictive Result sensitivity severity single-center SOFA SOFA score specificity Standard deviation surgical survival Time domain Variability were recorded worse prognosis [DOI] 10.1371/journal.pone.0249128 PMC 바로가기 [Article Type] Observational Study
The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcomeCOVID-19 결과 예측에서 심장 손상, 염증 및 응고 사이의 관계Article Published on 2021-03-222022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] abnormality adverse outcome anticoagulation treatment association attenuate attenuation benefit change Coagulation Coagulopathy Complication confounders consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CRP D-dimer determinant Effect Endpoint enrolled greater heparin Hospitalized In-hospital individuals Inflammation Inflammatory Inflammatory response Injury low molecular weight low molecular weight heparin mechanism Mortality observational study outcome PaO pathway Pneumonia Predictive markers primary endpoint Prognostic markers risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia sensitivity severity single-center subject therapy Treatment troponin T [DOI] 10.1038/s41598-021-85646-z PMC 바로가기 [Article Type] Article