A Comparative Analysis of Factors Influencing Two Outbreaks of Middle Eastern Respiratory Syndrome (MERS) in Saudi Arabia and South KoreaReview Published on 2019-12-032022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] addition Analysis Comparative coronavirus country death Endemic epidemiological Factor Fatality rate healthcare healthcare worker hospital IMPROVE information knowledge laboratory-confirmed MERS MERS-CoV middle Middle East Middle East Respiratory Syndrome (MERS), zoonosis occurred outbreak Outbreaks outcome Patient Perspective progression PROTECT reservoirs respiratory responses Saudi Arabia South Korea spread to synchronization Transmission viral infection virus World Health Organization [DOI] 10.3390/v11121119 PMC 바로가기 [Article Type] Review
The emergence of porcine epidemic diarrhoea in Croatia: molecular characterization and serologyResearch Article Published on 2019-07-182022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] alphacoronavirus carried caused characterized circulating clinical Consequences Croatia diarrhoea disease Domestic pig ELISA Epidemic Europe European Genotype high mortality Laboratory Measures molecular outbreak PEDV Porcine epidemic diarrhoea virus reported responsible Result S-INDEL serology spread to Strains Symptom the Coronaviridae USA virus vomiting [DOI] 10.1186/s12917-019-2002-x PMC 바로가기 [Article Type] Research Article
Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In VitroArticle Published on 2018-05-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acute respiratory illness acute respiratory syndrome anticancer antiviral activity approved drug Arabian Peninsula cause clinically Combination composed compounds country current drug drug candidates early stage exhibited Fatality rate gemcitabine Huh-7 cells Human human infection in vitro infected individual inhibit inhibitor kinase MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome occurred outbreak pathogen Replication respiratory RNA viruses saracatinib Saudi Arabia screened signaling pathways South Korea spread to Src-family kinase inhibitor synergistic therapeutic option Treatment tyrosine viral life cycle zoonotic [DOI] 10.3390/v10060283 PMC 바로가기 [Article Type] Article
Tracking the Origin and Deciphering the Phylogenetic Relationship of Porcine Epidemic Diarrhea Virus in EcuadorResearch Article Published on 2017-12-122022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, [키워드] Analysis Bayesian Canada China Chinese clade classical clinically comparison Complete conducted Ecuador epidemic diarrhea GenBank database isolate origin PEDV relationship S gene sequence spread to strain Strains suggested Transmission United State United States virus [DOI] 10.1155/2017/2978718 PMC 바로가기 [Article Type] Research Article
A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome매우 특이적인 파지 방어 시스템은 Vibrio cholerae mobilome의 보존된 특징입니다Research Article Published on 2017-06-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerate bacterial cell bacteriophage bacteriophages causative agent cell lysis cholerae chromosomal conserved contributed defend Defense diarrheal diarrheal disease disease cholera element Epidemic Evolution expansion favor feature FIVE Genetic genome replication genomic host cell host cells humans Infection investigated isolate killing Kinetics mechanism microbial community neighboring cell neighboring cells pathogen Patient phage phage genome phage-resistant phages predatory prevalent progeny Protective reduce respond selective spread to Stool strain unique Vibrio cholerae virulent widespread [DOI] 10.1371/journal.pgen.1006838 PMC 바로가기 [Article Type] Research Article
Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South KoreaOriginal Article Published on 2017-06-072022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] age Analysis Characteristics Chi-square collected Comorbidity Comparative complex conducted Contact country Emerging infectious disease Epidemic epidemic curve Epidemics epidemiological Epidemiology exhibited health system hospital infections Kingdom Logistic regression male MERS case MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus nosocomial occurred outbreak Outbreaks Prevent proportion reported resources respiratory syndrome coronavirus risk risk factor Risk factors Saudi Arabia Saudi MOH South Korea spread to Travel WHO World Health Organization [DOI] 10.1038/emi.2017.40 PMC 바로가기 [Article Type] Original Article
Impact of Middle East Respiratory Syndrome coronavirus (MERS ‐ CoV) on pregnancy and perinatal outcomeCase Report Published on 2016-03-022022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory illness Admission age ARDS Clinical course Contact contributed coronavirus CoV Critical care develop disease Factor female healthy high risk ICU immune response Impact Infection intensive care knowledge laboratory-confirmed last stage mechanical ventilation MERS MERS-CoV MERS-CoV infection Middle East Mortality MOST mother outcome Patient Perinatal outcome Pregnancy pregnant Pregnant woman reported respiratory Respiratory failure respiratory symptom Saudi Arabia spread to the patient viral respiratory [DOI] 10.1186/s12879-016-1437-y PMC 바로가기 [Article Type] Case Report
Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main ProteaseResearch Article Published on 2015-12-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Asian assessment catalysis catalytic activity Coronaviral coronavirus correlation country CoV Critical demonstrated domain domain III enzyme European Fatality rate FIVE highly pathogenic indicate investigated Jeddah M pro MERS MERS-CoV Middle East monomer Mutagenesis Mutation peptide protease Protein proteolytic activity provide required residue respiratory syndrome coronavirus Result Saudi Arabia spread to ultracentrifugation virus wild-type [DOI] 10.1371/journal.pone.0144865 PMC 바로가기 [Article Type] Research Article
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
The heptad repeat region is a major selection target in MERS-CoV and related coronavirusesArticle Published on 2015-09-252022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] adaptive Affect analyzed Antiviral bat Betacoronavirus coronavirus Efficiency Evolution heptad repeat Host host range HRs Human humans in vitro increase indicated inhibitor Interaction linker mammals MERS-CoV MERS-CoV infection Middle East Mutation other coronaviruses outbreak peptide Phylogeny populations residue respiratory syndrome coronavirus Result selected spread to stability strain zoonotic transmission [DOI] 10.1038/srep14480 PMC 바로가기 [Article Type] Article