sub-Saharan Africa

[키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article