Remdesivir significantly reduces SARS-CoV-2 viral load on nasopharyngeal swabs in hospitalized patients with COVID-19: A retrospective case-control studyArticle Published on 2022-05-012023-07-07 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] Corticosteroids COVID-19 cycle threshold RT-PCR Viral load [DOI] 10.1002/jmv.27598 PMC 바로가기
SARS-CoV-2 viral load and replication in postmortem examinations사후 검사에서 SARS-CoV-2 바이러스 부하 및 복제Article Published on 2022-05-012022-09-11 Journal: International Journal of Legal Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] age Autopsy Chain Reaction clinical Clinical autopsy Compliance COVID-19 criteria Cycle threshold value death deaths died examined Forensic Forensic autopsy Hospitalization Hospitalized infected case infected cases investigated lung mRNA nasopharyngeal Older p value performed positive postmortem examination Registered Replication replicative reverse transcriptase SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load statistically significant Swab tested the mean Viral load viral replication was performed [DOI] 10.1007/s00414-021-02753-2 PMC 바로가기 [Article Type] Article
SARS-CoV-2 rapid antigen tests provide benefits for epidemic control – observations from Austrian schoolsSARS-CoV-2 급속 항원 검사는 전염병 통제에 이점을 제공합니다 - 오스트리아 학교의 관찰Article Published on 2022-05-012022-09-11 Journal: Journal of clinical epidemiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Antigen antigen tests benefit Breakthrough infection breakthrough infections children Cohort conducted COVID-19 COVID-19 pandemic Delta detect detectable diagnose diagnostic diagnostic test effective Efficacy Epidemic Evidence false-positive rate information Large-scale testing Lateral Lateral flow device Live virus logistics observation PCR test PCR tests powerful tool Protein Public public health Rapid rapid antigen test Rapid antigen tests Repeat Repeat testing Reproduction number respiratory tract SARS-CoV-2 School Schools spring suppress tested the disease viral genomes Viral load viral loads virus genome virus particles while [DOI] 10.1016/j.jclinepi.2022.01.002 PMC 바로가기 [Article Type] Article
Virological and Clinical Determinants of the Magnitude of Humoral Responses to SARS-CoV-2 in Mild-Symptomatic Individuals경증-증상이 있는 개인의 SARS-CoV-2에 대한 체액 반응의 바이러스학적 및 임상적 결정인자Article Published on 2022-04-282022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute infection age anti-SARS-CoV-2 antibody Antibody titer clinical cohort study contribute COVID-19 determinant duration of symptom ELISA female group healthy individual humoral Humoral response humoral responses individual magnitude median Mild mild COVID-19 patients Negative PCR Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing response Neutralizing titer Older age plasma positive PCR pseudovirus recruited response RT-qPCR SARS-CoV-2 SARS-CoV-2-infected individuals Seroconversion symptom duration Symptoms viral dynamics Viral load [DOI] 10.3389/fimmu.2022.860215 PMC 바로가기 [Article Type] Article
Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19)코로나바이러스 감염증 2019(COVID-19) 환자를 위한 렘데시비르의 조기 치료와 관련된 임상 개선, 결과, 항바이러스 활성 및 비용Article Published on 2022-04-282022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] activity addition Admission Antiviral antiviral activity benefit changes in changes in viral load clinical Clinical deterioration Clinical improvement clinical outcomes Control cost COVID-19 COVID-19 patients Disease progression Follow-up groups Hong Kong hospital discharge Hospital stay Hospitalized hospitalized patient hospitalized patients IgG antibody improvement In-hospital death Inconclusive intensive care invasive ventilation lower risk median Mild-to-moderate Moderate COVID-19 multiple imputation on admission outcome oxygen Oxygen therapy Patient patients with COVID-19 positive progression Remdesivir retrospective cohort risk significantly shorter study outcomes the disease time Treatment Viral viral clearance Viral load WHO [DOI] 10.1093/cid/ciab631 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variant, Lineage BA.1, Is Associated with Lower Viral Load in Nasopharyngeal Samples Compared to Delta VariantSARS-CoV-2 오미크론 변이체, 계통 BA.1은 델타 변이체에 비해 비인두 샘플의 더 낮은 바이러스 부하와 관련이 있습니다.Article Published on 2022-04-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] collected Complete contribute COVID-19 Ct values cycle cycle threshold Delta delta variant determine evaluate France Health care health care workers high viral load load Lower mechanism nasopharyngeal swabs omicron Omicron variant Patient RdRP RT-PCR RT-PCR Ct Sample SARS-CoV-2 SARS-CoV-2 viral load Sequencing significantly higher specimen Spread Support swabs symptom onset threshold Transmissibility university university hospital upper respiratory tract vaccination variant Viral load virus excretion was performed was used whole genome Whole genome sequencing worker [DOI] 10.3390/v14050919 PMC 바로가기 [Article Type] Article
Diagnostic Performance of Six Rapid Antigen Tests for SARS-CoV-2SARS-CoV-2에 대한 6가지 신속 항원 검사의 진단 성능Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen Barcelona Basel carried causes Chicago coronavirus COVID-19 cycle threshold detect Diagnosis diagnostic effective Erlangen evaluate evaluated gold gold standard health center highest Houston Inc. infected with SARS-CoV-2 nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples PanBio Patient performance performed presenting ranged Rapid rapid antigen test Rapid antigen tests Rapid test rapid test cassette Real-time reverse transcription PCR reverse transcription PCR Roche Diagnostics RT-PCR SARS-CoV-2 SARS-CoV-2 test SD Biosensor sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus Siemen Spain specificity Stage Switzerland Symptoms Test tested the disease Viral load virus [DOI] 10.1128/spectrum.02351-21 PMC 바로가기 [Article Type] Article
Profiling of SARS-CoV-2 Subgenomic RNAs in Clinical Specimens임상 표본에서 SARS-CoV-2 서브게놈 RNA의 프로파일링Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] accessory protein age applied association canonical canonical sgRNA canonical sgRNAs changes in Characteristics clinical Clinical characteristics clinical samples collected COVID-19 COVID-19 patient COVID-19 patients deleted diagnostic discontinuous transcription event expression profile followed by Frame frameshift full-length genomic RNA identify independent Infection Isolation large cohort life cycle majority management marker MONITOR monitoring Next-generation sequencing Numerous Open reading frame ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 Patient PCR positive Potential biomarker potential biomarkers produced profile Profiling progression Protein provide real-time RT-PCR respiratory respiratory sample Respiratory samples RNA RNA-Seq RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs sgRNA sgRNAs specimen specimen collection Stool stool samples subgenomic RNA subgenomic RNAs subgenomic. the patient transcript translation Treatment treatment of COVID-19 patients undetectable variant Viral load [DOI] 10.1128/spectrum.00182-22 PMC 바로가기 [Article Type] Article
Comparison of Saliva and Midturbinate Swabs for Detection of SARS-CoV-2SARS-CoV-2 검출을 위한 타액과 중갑개 면봉의 비교Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Chain Reaction close contact collected concerning Contact COVID-19 COVID-19 case COVID-19 cases Critical Ct values demonstrated detection Early detection Evidence Frequency General population greater Health care health care workers higher RNA copy numbers identify IMPROVE increasingly Incubation period Infection less likelihood manuscript midturbinate swab nasal swabs occur onward transmission polymerase chain polymerase chain reaction positive presymptomatic Prevent provided risk RNA copy number RT-PCR Saliva saliva samples SARS-CoV-2 SARS-CoV-2 detection Self-reported symptoms sensitivity significantly Support supported Swab symptom onset Symptoms Transmission variant Viral detection Viral load virus [DOI] 10.1128/spectrum.00128-22 PMC 바로가기 [Article Type] Article
Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trialCOVID-19 입원 환자의 바이러스 역학에 대한 렘데시비르의 효과: 무작위, 통제, 공개 라벨 DisCoVeRy 시험의 모델링 분석Randomized Controlled Trial Published on 2022-04-272022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI analysed Analysis antiviral efficacy average cells conducted COVID-19 Effect Efficacy EudraCT high viral load Hospitalized hospitalized patient hospitalized patients infected cell infected cells inter-individual kinetic mathematical mathematical model median median time nasopharyngeal normalized Open-label Patient predict profile randomization Randomized reduced reducing reduction Remdesivir SOC Standard of care stratified symptom onset the median treatment initiation Trial Variability viral clearance viral dynamics Viral load viral loads viral replication [DOI] 10.1093/jac/dkac048 PMC 바로가기 [Article Type] Randomized Controlled Trial