Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
Research Article
[키워드] acute lung injury
acute respiratory distress
acute respiratory syndrome
advanced age
age
analyses
analysis
anti-inflammatory action
ARDS
Author
cause
Comprehensive
contributed
coronavirus
correlated
develop
different
differential expression
diminishe
disease
displaying
exacerbated
expression
Gene
genomic
H5N1
host response
IFN-β
IL-8
in viral
increase in
individual
individuals
Infection
Inflammation
influenza A
Innate
Intervention
life-threatening
Lungs
macaque
macaques
Microarray
modulation
molecular
mRNA level
NF-κB
outcome
pandemic
pathogen
Pathogenesis
pathology
Pathways
Patient
primate
pro-inflammatory gene expression
Protective
provide
reduce
reduced
Replication
response
reveal
SARS-CoV
SARS-CoV infection
severe
severe pathology
severity
shown
significantly
significantly more
syndrome
Treatment
type I
Type I IFN
type I interferon
viral infection
viral replication
viral respiratory
virus infection
virus replication
without affecting
[DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article