Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A플리티뎁신은 숙주 단백질 eEF1A를 표적으로 삼아 SARS-CoV-2에 대한 강력한 전임상 효능을 갖고 있다.Research Article Published on 2021-02-262022-09-10 Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity antiviral effects aplidin approach approval Cell Cell culture cells cellular complementary coronavirus COVID-19 depsipeptide drug drug-resistant Efficacy effort elongation factor eukaryotic translation Factor Host host protein host proteins in vitro in vivo inhibitor inhibitors inhibitory concentration life cycle lung Lungs magnitude mice mouse model Mouse models mutant Perspective Plitidepsin prophylactic treatment reduction Remdesivir required respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 target therapeutic Toxicity translation translational Treatment Viral Viral protein Viral proteins viral replication virus white [DOI] 10.1126/science.abf4058 PMC 바로가기 [Article Type] Research Article
Perception of COVID-19 Physical Distancing Effectiveness and Contagiousness of Asymptomatic Individuals: Cross-sectional Survey of Deaf and Hard of Hearing Adults in the United StatesOriginal Paper Published on 2021-02-252022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] Administered age Asymptomatic asymptomatic individual Confusion connection contagiousness coronavirus COVID-19 COVID-19 knowledge COVID-19 pandemic cross-sectional survey Deaf DHH dropped education Effectiveness female Gender Hard hard of hearing health emergency Hearing information item knowledge less misinformation objective Pandemics Perception physical distancing predicted predictors question race rapid increase reducing Result SARS-CoV-2 SIGN Sign Language significantly social media spread of COVID-19 survey survey platform the disease the United State white without symptoms [DOI] 10.2196/21103 PMC 바로가기 [Article Type] Original Paper
Making a COVID-19 vaccine that works for everyone: ensuring equity and inclusivity in clinical trials모두에게 효과가 있는 COVID-19 백신 만들기: 임상 시험에서 형평성과 포괄성 보장Research Article Published on 2021-02-242022-09-10 Journal: Global Health Action [Category] 임상, [키워드] applicability Asian Bame baseline best black BNT162b2 ChAdOx1 clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine trials COVID-19 vaccines demographics Deprivation displaying Efficacy and safety equity ethnic minorities Ethnicity European group health equity healthcare Innovation lack Making Medical research morbidity Mortality mRNA pandemic Participants phenotype recruited Reporting Research risk shown Transparency Trial Vaccine vaccine candidate Vaccines white [DOI] 10.1080/16549716.2021.1892309 PMC 바로가기 [Article Type] Research Article
Pandemic precarity: COVID-19 is exposing and exacerbating inequalities in the American heartlandClinical Trial Published on 2021-02-232022-10-04 Journal: Proceedings of the National Academy of Sciences of [Category] 임상, [키워드] Affect affected age black consequence COVID-19 COVID-19 infection COVID-19 pandemic Disparities economic insecurity Effect effort exacerbating food insecurity Gender group groups Health initial interview Longitudinal data morbidity and mortality outcome pandemic Person Racial racial and ethnic inequality raising recession regressions resident risk Shock socioeconomic inequality. Support The United States weakened white women [DOI] 10.1073/pnas.2020685118 PMC 바로가기 [Article Type] Clinical Trial
Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China중국 후난성 COVID-19 증상이 있는 퇴원 환자의 초기 특징과 예후 사이의 상관관계Article Published on 2021-02-222022-09-01 Journal: Scientific Reports [Category] MERS, 임상, 진단, 치료기술, [키워드] 95% CI Admission Alanine alanine aminotransferase appearance aspartate Aspartate aminotransferase Blood blood cell Cell China consolidation coronavirus correlation COVID-19 COVID-19 pneumonia determine discharge discharged patient discharged patients Diseases during admission feature GGO ground-glass opacity Hospitalization Infectious disease involved Laboratory Lactate lactate dehydrogenase lesion lobe lobes Logistic regression analysis Medical research Most patients multiple lesion multiple lesions neutrophil neutrophil count neutrophil counts occurred Patient patients Pneumonia Prognosis radiological feature radiological features radiological finding significant difference statistically significant difference symptom onset symptomatic the disease two group two groups white White blood cell with COVID-19 [DOI] 10.1038/s41598-021-83654-7 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 (COVID-19) can predispose young to Intracerebral hemorrhage: a retrospective observational studyObservational Study Published on 2021-02-192022-10-04 Journal: BMC Neurology [Category] 임상, [키워드] Admission affected age Arterial hypertension Central nervous system chronic arterial hypertension, hematoma. Clinical outcome CNS control group Coronavirus disease 2019 COVID COVID-19 COVID-19 negative COVID-19 positive patient Diabetes Mellitus discharge Encephalitis evaluated Factor Gender GOS hematoma hemorrhage Hospital stay hypertension ICH Intracerebral hemorrhage intraventricular lab Laboratory less Mental neurological no significant difference Occurrence other organ Partial Platelet positive patient prothrombin radiological reported Respiratory system Result retrospective scale Seizures Sex significant difference significantly lower smoking subject the disease the patient time two group two groups variable virus Volume WBC white younger patient [DOI] 10.1186/s12883-021-02109-8 PMC 바로가기 [Article Type] Observational Study
Coronavirus disease 2019 (COVID-19) can predispose young to Intracerebral hemorrhage: a retrospective observational studyObservational Study Published on 2021-02-192022-10-27 Journal: BMC Neurology [Category] COVID-19, MERS, [키워드] Admission affected age Arterial hypertension Central nervous system chronic arterial hypertension, hematoma. Clinical outcome CNS control group Coronavirus disease 2019 COVID COVID-19 COVID-19 negative COVID-19 positive patient Diabetes Mellitus discharge Encephalitis evaluated Factor Gender GOS hematoma hemorrhage Hospital stay hypertension ICH Intracerebral hemorrhage intraventricular lab Laboratory less Mental neurological no significant difference Occurrence other organ Partial Platelet positive patient prothrombin radiological reported Respiratory system Result retrospective scale Seizures Sex significant difference significantly lower smoking subject the disease the patient time two group two groups variable virus Volume WBC white younger patient [DOI] 10.1186/s12883-021-02109-8 PMC 바로가기 [Article Type] Observational Study
COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factorsCovid-19 Published on 2021-02-152022-10-31 Journal: European Journal of Epidemiology [Category] COVID-19, MERS, SARS, [키워드] association Autoimmune disease black body mass index cardiovascular disease characterisation characteristic Cohort Comorbidities Comorbidity contributed contributing to covariates COVID-19 COVID-19 mortality death diabetes employment enrolment explained Factors healthcare worker hypertension increased risk inhibitor investigated lipids Male sex medications Mortality MOST multivariable Non-COVID-19 oral steroid prospective cohort Regression model regression models reported risk risk factor SARS-CoV-2 selected smoker smoking supplementary material UK biobank white with COVID-19 [DOI] 10.1007/s10654-021-00722-y PMC 바로가기 [Article Type] Covid-19
COVID-19 incidence and mortality in Nigeria: gender based analysisHealth Policy Published on 2021-02-122022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis ARIMA average Bayesian information criterion COVID-19 COVID-19 case COVID-19 incidence Daily Daily incidence Daily mortality death case develop distribution Evidence female finding fold Gender highlight incidence linear male maximum Mortality Nigeria P -value pandemic Predictive random Result risk Risk factors significantly higher VARMA white Wilcoxon signed-rank test [DOI] 10.7717/peerj.10613 PMC 바로가기 [Article Type] Health Policy
Trends in US Pediatric Hospital Admissions in 2020 Compared With the Decade Before the COVID-19 PandemicResearch Published on 2021-02-122022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, [키워드] 95% CI Admission Admissions age association Asthma Care changed changes in condition conditions contributing to coronavirus disease COVID-19 COVID-19 pandemic cross-sectional database decrease determine Diabetic diagnose Diagnosis discharged examined finding heterogeneous hospital Hospital admission hospitals Importance incidence individuals Inpatient inpatient admission Kawasaki syndrome measure median mental health number objective pandemic participant Patient pediatric Point predicted public health emergency reduced reduction in reductions in Relevance Result seasonal septal setting social distancing measures System the United State trauma trend unmet need variety Volume white [DOI] 10.1001/jamanetworkopen.2020.37227 PMC 바로가기 [Article Type] Research