Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?
Immunology
[키워드] “cytokine storm”
ACE2
activating
Activation
Affect
affecting
alveolar epithelial cells
angiotensin-converting enzyme 2
Anti-viral
Cathepsins
caused
cellular entry
cellular receptors
cellular signaling pathway
Community
coronavirus
CoV
COVID-19
Deleterious
dendritic cell
downregulating
downregulation
DPP4
Epidemics
event
Exacerbation
Factor
furin
glycoprotein
H1N1
Haemagglutinin
Health
Host
IL-8
infected patients
Inflammation
initial
initial viral load
Innate
innate immune response
innate immune responses
involved
Ligand
ligands
Like
lung
lung innate immunity
Macrophage
middle
multiple organ failure
outbreak
pandemic
Pandemics
pro-inflammatory mediator
promoted
protease
Proteases
Protein
Resolution
respiratory
RNA genome
SARS-CoV
SARS-CoV-2
serine 2
single-stranded
survival
syndrome
T-cell
TLR
TMPRSS2
transmembrane serine protease
triggering
trimeric spike
TTSP
type I
type III
virus
virus entry
[DOI] 10.3389/fimmu.2020.01229 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.01229 PMC 바로가기 [Article Type] Immunology