Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS‐CoV‐2 infectionTissue‐specific Progenitor and Stem Cells Published on 2021-01-262022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, SARS, [키워드] ACE2 adipose adult stem cells angiotensin Blood Bone marrow cell line cellular therapy complications conditioned COVID‐19 Critical Cytopathic effect demonstrated Effect ELISA enzyme evaluated Evidence excluded Express fetal fetal stem cells host cell host cell factor Human human tissue immunomodulatory properties medium Mesenchymal stromal cell mesenchymal stromal cells (MSCs) MSC MSCs not express potential therapy Proteins pseudovirus raised SARS‐CoV‐2 SARS‐CoV‐2 infection stromal cell Support tested therapy tissue TMPRSS2 transmembrane serine protease Treatment Viral particles virus were expressed western blot wild strain [DOI] 10.1002/sctm.20-0385 PMC 바로가기 [Article Type] Tissue‐specific Progenitor and Stem Cells
An extended Weight Kernel Density Estimation model forecasts COVID-19 onset risk and identifies spatiotemporal variations of lockdown effects in ChinaArticle Published on 2021-01-252022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, [키워드] China Chinese COVID-19 decrease density Effect effective estimation evaluate heterogeneity High-resolution identify implementation Infectious diseases Kernel lockdown medium predict reduce risk Risk factors risk of COVID-19 spatiotemporal symptom onset Variation weight Wuhan [DOI] 10.1038/s42003-021-01677-2 PMC 바로가기 [Article Type] Article
A Descriptive Study on Causes of Death in Hospitalized Patients in an Acute General Hospital of Southern Italy during the Lockdown due to Covid-19 OutbreakArticle Published on 2021-01-252022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] analyzed cause Chest computed tomography Clinical management collected COVID-19 death died Endpoint epidemiological surveys False negative females Frequency Giuseppe hospital Infection information Italy laboratory data males medium Mortality mortality rate nasopharyngeal negative RT-PCR occurred Oropharyngeal oropharyngeal swabs Other overall mortality patients positive primary endpoint radiological radiological feature reported RT-PCR secondary tested [DOI] 10.3390/healthcare9020119 PMC 바로가기 [Article Type] Article
Evaluation of two fluorescence immunoassays for the rapid detection of SARS-CoV-2 antigen—new tool to detect infective COVID-19 patientsBiochemistry Published on 2021-01-212022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] antigen detection automated chain characterized clinical sample contagiousness Corporation COVID-19 COVID-19 diagnosis COVID-19 patient detect Diagnosis Diagnostic method Diego early stage evaluated identify immunoassay Inc. indicate individuals Infection infective Laboratory medium Nasopharyngeal swab Patient positive Rapid diagnostic test reaction reduce Result RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SD Biosensor sensitivity significantly specimens symptom onset threshold Transport USA Viral load [DOI] 10.7717/peerj.10801 PMC 바로가기 [Article Type] Biochemistry
Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans인간 병원체 크립토코커스 네오포르만스와 크립토코커스 데네오포르만스 사이의 종 경계를 강화하는 요인Research Article Published on 2021-01-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Alternative pathway Aneuploidy Bacterial block component Cryptococcus Cryptococcus neoforman Cryptococcus neoformans deleting determine DNA DNA sequence DNA sequences eukaryote eukaryotes Factor fecundity Frequency fungal Genetic genetic recombination human pathogen hybrid hybridization identify increase in incubated instance interspecific interspecific hybrid interspecific hybrids isolate lack lead limit Loss maintain mechanism medium meiosis meiotic recombination Msh2 parent parental parents pathogenic pathway phenotype Previous studies previous study produced progeny Recombination Sequencing sexual reproduction strain Structure structures transgressive phenotype transgressive phenotypes unique Variation viability whole-genome whole-genome sequencing yeast [DOI] 10.1371/journal.pgen.1008871 PMC 바로가기 [Article Type] Research Article
Comparison of pre-analytical characteristics for molecular and serological diagnostics of COVID-19Article Published on 2021-01-192022-11-01 Journal: GMS Hygiene and Infection Control [Category] COVID-19, [키워드] addition Amy analyzed Brushing Characteristics comparable Concordance concordance rate conducted correlation COVID-19 COVID-19 patients diagnosis of SARS-CoV-2 diagnostic diagnostics early stage healthcare worker hospitalized patient Infection less medium molecular nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs no difference Patient PCR performed pharyngeal pharyngeal lavage positive patient positive patients positive result Predictive RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection serological specimen Swab swabs Transmission [DOI] 10.3205/dgkh000374 PMC 바로가기 [Article Type] Article
The distribution of SARS-CoV-2 contamination on the environmental surfaces during incubation period of COVID-19 patientsCOVID-19 환자의 잠복기 동안 환경 표면에 대한 SARS-CoV-2 오염 분포Article Published on 2021-01-152022-09-11 Journal: Ecotoxicology and environmental safety [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 bathroom bedroom collected Contamination coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient detect distribution environmental contamination environmental factor environmental factors functional had no in viral Incubation Incubation period living room medium patients polyester positive rate positive rates positive sample quarantine respiratory role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tested Transmission Transport transport medium Viral Viral transport medium [DOI] 10.1016/j.ecoenv.2020.111438 PMC 바로가기 [Article Type] Article
In silico exploration of novel protease inhibitors against coronavirus 2019 (COVID-19)Research article Published on 2021-01-142022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료제, [키워드] accelerate ADME ADME studies affected analyzed antiviral properties Antiviral treatment applied approaches binding energy binding free energy can be used complex Compound compounds Coronavirus 2019 COVID-19 Critical docked drug Drug discovery fluctuation Health in-silico indicate Infection inhibitor inhibitors Interaction main protease MD simulation medium MM/PBSA molecular docking Molecular dynamics simulation MPro much higher performed probe protease Protease inhibitor Protein residue retrieved Ritonavir SARS-CoV-2 SARS-CoV-2 main protease Spread target trajectory treat Virtual screening virus with COVID-19 [DOI] 10.1016/j.imu.2021.100516 [Article Type] Research article
New Onset Granulomatosis with Polyangiitis Associated with COVID-19Case Report Published on 2021-01-132022-10-31 Journal: Case Reports in Dermatological Medicine [Category] COVID-19, [키워드] Complication coronavirus disease COVID-19 COVID-19 infection cutaneous vasculitis diagnostic Diseases granulomatosis Granulomatosis with polyangiitis immunosuppressive knowledge Manifestations medium New Onset overlap Patient patients polyangiitis raise shown Vasculitis vessel with COVID-19 [DOI] 10.1155/2021/8877292 PMC 바로가기 [Article Type] Case Report
Slump in Hospital Admissions for Stroke, a Fact of an Uncertain Nature That Requires ExplanationArticle Published on 2021-01-132022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] 95% confidence interval Activation Admission Analysis attack caused conducted coronavirus disease COVID-19 Effect explanation Fact Health healthcare hospital Hospitalization increase in less material medium Mortality multifactorial Nature pandemic pathology Poisson regression model public health public health crisis reduction remained reperfusion stroke stroke unit suffered therapy Treatment [DOI] 10.3390/brainsci11010092 PMC 바로가기 [Article Type] Article