Clinical characterization and therapeutic targets of vitamin A in patients with hepatocholangiocarcinoma and coronavirus disease간도 콜랑 지오 마쇄종 및 코로나 바이러스 질환 환자에서 비타민 A의 임상 적 특성 및 치료 적 표적Research Paper Published on 2021-06-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Anti-inflammatory anti-inflammatory actions Anti-viral approach Bioinformatics analysis BRD2 CDK4 Cell Characteristics clinical Clinical finding Clinical findings Clinical management contribute coronavirus coronavirus disease COVID-19 CXCR3 database determine function genome analysis GPT hepatocholangiocarcinoma ICAM1 identify Immunity immunopotentiation inflammatory reaction MAPK1 mechanism mechanism of action Medicine molecular functions molecular mechanism molecular mechanisms morbidity and mortality mortality rate network pharmacology NOS2 oxidative stress Pathways Patient patients with COVID-19 pharmacological Potential treatment Prognosis recent recurrence Signaling suppression survival rate susceptibility target therapeutic therapeutic target TMPRSS13 Transcriptome Vitamin vitamin A were used [DOI] 10.18632/aging.203220 PMC 바로가기 [Article Type] Research Paper
The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19Review Published on 2021-06-282022-11-01 Journal: Diseases [Category] COVID-19, [키워드] Acute kidney injury addition analyzed appear caused Cell Comorbidity conditions COVID-19 COVID-19 patient death distress etiology global public health high mortality IMPROVE Inflammatory cytokine storm Injury investigated kidney kidneys mechanisms outcome oxidative stress pandemic of COVID-19 patients patients with COVID-19 Potential protective effect renal renal function renal impairment SARS-CoV-2 subject syndrome the cytokine storm tissue Vitamin Vitamin C with COVID-19 [DOI] 10.3390/diseases9030046 PMC 바로가기 [Article Type] Review
Upregulation of oxidative stress gene markers during SARS-COV-2 viral infectionArticle Published on 2021-06-262023-06-14 Journal: Free radical biology & medicine [Category] MERS, SARS, [키워드] antioxidant bioinformatics calprotectin COVID-19 lung autopsies myeloperoxidase Neutrophils oxidative stress Pro-oxidant respiratory viral infection S100A8 S100A9 Saliva SARS-CoV-2 [DOI] 10.1016/j.freeradbiomed.2021.06.018 PMC 바로가기 [Article Type] Article
COVID-19 Infection and Circulating Microparticles—Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel DiseaseArticle Published on 2021-06-262022-10-30 Journal: Molecular neurobiology [Category] COVID-19, MERS, SARS, [키워드] accumulating acute respiratory syndrome affected affecting Alzheimer’s disease Brain cellular activation cerebral Cerebral small vessel disease Cerebrovascular disease circulating Coagulopathy complications consequence COVID-19 COVID-19 infection COVID-19 pathogenesis Critical CVD Dementia disease elevated Endothelial dysfunction etiology Evidence Factor Inflammation knowledge Manifestations Microparticle microparticles microthrombi morbidity and mortality neurodegeneration Neuroinflammation novel coronavirus disease oxidative stress pandemic era risk factor SARS-CoV-2 small vessel stroke subsequent subtype Vascular [DOI] 10.1007/s12035-021-02457-z PMC 바로가기 [Article Type] Article
Oxidative Stress and Inflammation in SARS-CoV-2- and Chlamydia pneumoniae -Associated Cardiovascular DiseasesReview Published on 2021-06-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome antioxidant antioxidants approach Bacteria cardiovascular cardiovascular disease cardiovascular diseases Chlamydia pneumoniae Compound coronavirus cytokine production Evidence highlight infections Inflammation Inflammatory involved molecular Novel coronavirus oxidative oxidative stress pandemic Pathogenesis pathway pneumoniae provided reactive oxygen specy Respiratory pathogens responsible SARS-CoV-2 therapeutic [DOI] 10.3390/biomedicines9070723 PMC 바로가기 [Article Type] Review
Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea VirusResearch Article Published on 2021-06-232022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus, [키워드] Administered administration affected analyses Analysis anti-inflammatory effect Antiviral average biological process caused Colon Concentration Culture determine diarrhea differentially expressed gene dismutase dose drug Effect epidemic diarrhea Gene ontology growth histologic IL-1 β IL-6 IL-8 implication IMPROVE indicated Infection infectious dose Inflammation inhibit inoculated intestinal intestine lesions mechanism metabolism Microarray morphology neutrophil degranulation oxidative stress Oxide pathway PEDV peroxidase plasma Prevent Protein proteomic randomly divided redox status reduce reduction Replication rescued Result shown significantly increased small intestine TCID three group tissue treat Treatment villus Viral load virus were recorded Zinc zinc oxide [DOI] 10.1155/2021/3055810 PMC 바로가기 [Article Type] Research Article
Clinical Performance of Paraoxonase-1-Related Variables and Novel Markers of Inflammation in Coronavirus Disease-19. A Machine Learning ApproachArticle Published on 2021-06-212022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] alteration approach Biomarkers cause CCL2 chemokine chemokines circulating clinical clinical variable Comparisons COVID-19 COVID-19 negative death diagnosis of COVID-19 galectin-3 glycoprotein healthy individuals identify Inflammation inflammatory reaction innate immune system Interaction Ligand machine learning marker motif novel oxidative stress parameter parameters paraoxonase-1 Patient patients patients with COVID-19 performance PON1 positive positive patient Predictive pro-inflammatory mediator PROTECT recruited SARS-CoV-2 SARS-COV-2 infection serum synergy the disease variable was used [DOI] 10.3390/antiox10060991 PMC 바로가기 [Article Type] Article
Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDSArticle Published on 2021-06-202022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome addition Admission anti-oxidative ARDS association Biomarker Biomarkers CD8 clinical Clinical data correlated COVID-19 Critical care Critically ill patient CRP data management Defense discharge elevated eligibility Essential ICU IgG IL-10 IL-1β IL-6 Ill immune response immunological Inflammation Inflammatory cytokines inflammatory parameters intensive care intravenous investigated Lymphocyte subset majority Micronutrient NK cell non-survivor nutrient supplementation organ damage oxidative stress PaO parameters Patient PCT peroxidase resulting Retrospective study screened selen SELENOP Selenoprotein P severe ARDS severe COVID-19 severe disease Significance significantly single-center suffered Support survived survivor syndrome T cell the patient Treatment with COVID-19 Zinc [DOI] 10.3390/nu13062113 PMC 바로가기 [Article Type] Article
Application of Clinical Decision Support System to Assist Breast Cancer Patients with Lifestyle Modifications during the COVID-19 Pandemic: A Randomised Controlled TrialRandomized Controlled Trial Published on 2021-06-202022-10-04 Journal: Nutrients [Category] MERS, SARS, 임상, [키워드] accompanied aggregation application assigned assist Blood blood glucose Breast Breast cancer cardiovascular diseases cardiovascular risk factors carried cholesterol clinical clinical decision support systems clinician Control control arm Controlled COVID-19 COVID-19 pandemic decision elevated Endpoint enrolled evaluated fasting Fat mass food healthy LDL management marker Mediterranean diet Modification obesity oxidative stress Patient personalised physical activity promote provided Quality of life randomised controlled Randomly receiving remained significantly Stage Support System Trial was recorded women [DOI] 10.3390/nu13062115 PMC 바로가기 [Article Type] Randomized Controlled Trial
He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic StudyPharmacology Published on 2021-06-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan [DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology