Increasing proteomics throughput News & Views Published on 2021-03-252022-10-05 Journal: Nature biotechnology [Category] 바이오마커, [키워드] Increasing proteomics [DOI] 10.1038/s41587-021-00881-z [Article Type] News & Views
Sickle Cell Trait Modulates the Proteome and Phosphoproteome of Plasmodium falciparum -Infected Erythrocytes겸형적혈구형질이 말라리아 원충 플라스모디움 팔시파룸에 감염된 적혈구의 단백질체 및 인산화 단백질체를 조절한다.Original Research Published on 2021-03-242024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] erythrocyte hemoglobin S membrane phosphorylation Plasmodium falciparum proteomics [DOI] 10.3389/fcimb.2021.637604 PMC 바로가기 [Article Type] Original Research
Immunoinformatic approach to design a multiepitope vaccine targeting non-mutational hotspot regions of structural and non-structural proteins of the SARS CoV2Bioinformatics Published on 2021-03-232022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 3D structure Analysis Antigen antigen processing antigenicity approach B cell binding affinity binding energy calculated caused Cell complex coronavirus 2 cross-reactivity database demonstrated docking envelope protein epitope Epitopes evaluated Extracellular high mortality HLA host cell hotspot IFN immune response Immune simulation induce Infection injection interacting residue Interaction leukocyte linker MDs Membrane proteins memory Microbiome Molecular dynamics simulation morbidity multiepitope vaccine Mutation mutations non-structural protein ORF1ab polyprotein ORF3a protein ORF8 protein outbreak pandemic Physicochemical properties predicted Protein proteomics Region respiratory Result SARS CoV2 screened selected sensitivity Seven similarity strong immune response Study design Surface glycoprotein T cell the vaccine TLR TLRs Toll-like receptor Toxicity vaccination Vaccine vaccine construct virus was performed [DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics
Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epitheliumArticle Published on 2021-03-232022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 3D model atmospheric Bronchial epithelium Calu-3 Calu-3 cell line can be used Cell Cell Biology cells characterized component Defense defined demonstrated drug Drug testing drugs epithelial epithelial cell evaluate Evolution functional highlight human lung immune response in vitro model Inhaled investigated lack maintain medium mucosal immune NHBE Particle Particles pathway Protein proteomics Quantitative reduced respiratory pathogen Respiratory system models SARS-CoV-2 secrete secreted protein Secretome Serum protein significant difference Toxicity viability [DOI] 10.1038/s41598-021-86037-0 PMC 바로가기 [Article Type] Article
Non-targeted proteomics of acute respiratory distress syndrome: clinical and research applicationsReview Published on 2021-03-202022-10-29 Journal: Proteome Science [Category] COVID-19, [키워드] acute respiratory distress applied ARDS caused characterized Clinical applications disease distress drug target high mortality rate Hypoxemia identify mechanism Non-targeted proteomics pathway proteomics Research Study designs syndrome therapeutic drug treat [DOI] 10.1186/s12953-021-00174-y PMC 바로가기 [Article Type] Review
[Differential proteomic screening of plasma exosomes before and after magnesium isoglycyrrhizinate treatment in chronic hepatitis B]Article Published on 2021-03-202023-06-12 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] Chronic Hepatitis B Exosome Magnesium isoglycyrrhizinate plasma proteomics [DOI] 10.3760/cma.j.cn501113-20200222-00062
Proteomic blood profiling in mild, severe and critical COVID-19 patients경증, 중증 및 중증 COVID-19 환자의 단백질체 혈액 프로파일링Comparative Study Published on 2021-03-182022-08-31 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome analyses ARDS Autoimmune Biomarker Blood blood protein blood proteins changes in CKAP4 Control COVID-19 COVID-19 cases COVID-19 disease COVID-19 positive patient Critical critical COVID-19 patient death Differential expression analysis disease Disease progression disease severity generate group identify IL-1ra IL6 in some individual individuals infected individuals Infection Inflammation LILRB4 Mild mild respiratory mild respiratory tract infection MONITOR multi-organ failure nine Olink PD-L1 potential therapeutic targets progression Protein proteomic proteomics respiratory respiratory distress respiratory tract infection SARS-CoV-2 pandemic severe pneumonia significantly syndrome the disease viral infection Visualization was performed [DOI] 10.1038/s41598-021-85877-0 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcriptionSARS-CoV-2 백신 ChAdOx1 nCoV-19 인간 세포주의 감염은 매우 높은 수준의 SARS-CoV-2 S 당단백질 유전자 전사와 함께 낮은 수준의 바이러스 백본 유전자 전사를 나타냅니다Research Published on 2021-03-152022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] A549 A549 cell A549 cell line A549 cell lines A549 cells addition Adenovirus approach backbone Cell Cell culture cell line cell lines Cell Nucleus cells ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical trial coding Direct RNA sequencing expected expression Gene Expression Genome globe HEK293 human cell line Infection nucleus phosphoproteome polyadenylation site Protein proteome proteomic proteomics Quantitative recombinant adenovirus Replication Result reveal S glycoprotein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S glycoprotein SARS-CoV-2 vaccine splice supplementary material the cell the SARS-CoV-2 transcript Transcription transcriptomic Vaccine Viral [DOI] 10.1186/s13073-021-00859-1 PMC 바로가기 [Article Type] Research
Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem CellsArticle Published on 2021-03-122023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] adipose-derived stromal/stem cells Extracellular vesicles hypoxia mesenchymal stromal/stem cells proteomics renal tubular epithelial cells [DOI] 10.3390/ijms22062873 PMC 바로가기 [Article Type] Article
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of deathCOVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다Research Article Published on 2021-03-112022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues [DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article