Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak controlReview Published on 2015-08-282022-10-31 Journal: Experimental & Molecular Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome approved can be used cause clinically Coronavirus infection cough death deaths develop drug target Fatality rate Fever Health highlight hospital Human infected individuals infections MERS-CoV MERS-CoV infection Middle East Multiorgan dysfunction Occurrence outbreak raised reported respiratory syndrome coronavirus respiratory tract infection South Korea spread to syndrome therapeutic targeting thought Transmission transmitted virus [DOI] 10.1038/emm.2015.76 PMC 바로가기 [Article Type] Review
Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operationCase Report Published on 2015-02-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] addition affected cause caused collected component coronavirus country Critical disease effective effort epidemic diarrhea epidemiological Evidence Feed highlight initiated limit Measures Mortality naïve Neonatal outbreak PEDV pellet positive provided RT-PCR Spread spread to stages Surveillance swine tested the United State The United States Transmission Vaccine virus [DOI] 10.1186/s12917-015-0348-2 PMC 바로가기 [Article Type] Case Report
Structural and functional characterization of MERS coronavirus papain-like proteaseResearch Published on 2014-06-042022-10-29 Journal: Journal of Biomedical Science [Category] Coronavirus, [키워드] Analysis antiviral drug antiviral target Circular Coronaviral coronavirus Coronaviruses CoV demonstrated Deubiquitination develop European country exhibit expressed Fatality rate functional functional consequence highly pathogenic indicated inhibiting Jeddah kinetic MERS coronavirus MERS-CoV Middle East monomer natural mutation organized Papain-like protease proteolytic proteolytic activity respiratory syndrome coronavirus Result SARS-CoV Saudi Arabia spread to therapy ultracentrifugation virus [DOI] 10.1186/1423-0127-21-54 PMC 바로가기 [Article Type] Research
A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and VaccinesResearch Article Published on 2013-12-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells bind binding block caused culture supernatant Developing development Dipeptidyl peptidase 4 domain DPP4 effective eight expressed fused high mortality IgG Fc induce inhibited MERS MERS-CoV MERS-CoV infection mice Middle East neutralize Novel coronavirus Protein purified RBD RBD protein receptor reported residue respiratory infectious disease S-specific antibodies Safe Saudi Arabia spike Spread spread to Strong syndrome therapeutic Therapeutics Vaccine [DOI] 10.1371/journal.pone.0081587 PMC 바로가기 [Article Type] Research Article
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
A novel coronavirus capable of lethal human infections: an emerging pictureReview Published on 2013-02-282022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute respiratory illness Analysis caused Cluster Coronavirus (CoV) died event Evidence humans index case individual laboratory-confirmed Middle East new virus Novel coronavirus outbreak Patient provided renal renal failure reported SARS-coronavirus SARS-CoV Saudi Arabia severe respiratory infection spread to Travel virus [DOI] 10.1186/1743-422X-10-66 PMC 바로가기 [Article Type] Review
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS VirusResearch Article Published on 2012-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome antibody C57BL/6 candidate vaccine caution challenge change changes in China component control group country dosage eosinophil evaluated exhibited ferret Histopathology Human hypersensitivity immunopathology inactivated indicated Infection infiltration Influenza initiated led to Live virus lung Lung disease mice NHP occurred Occurrence pathologic PBS pulmonary responses Result S protein SARS Coronavirus SARS-CoV SARS-CoV vaccine serum antibody Serum neutralizing antibody severe Significant reduction significantly spread to Th2-type the vaccine Vaccine Vaccine development virus VLP [DOI] 10.1371/journal.pone.0035421 PMC 바로가기 [Article Type] Research Article
Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection ☆Article Published on 2003-11-262022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome After Antiviral compound Antiviral treatment approach approaches carried caused China Complete consequence coronavirus country criteria deaths diagnostic test different East effort emerging infection epidemiological Epidemiology Evidence example found Genome globe group Human inactivation Infectious disease International Laboratory laboratory diagnosis molecular virology outbreak Research RNA SARS patients SARS-associated coronavirus (SARS-CoV) SARS-CoV sequenced severe Severe acute respiratory syndrome (SARS) severe respiratory illness spread to stability starting Transmission Vaccine viral infection virus WHO World Health Organization World Health Organization (WHO) [DOI] 10.1016/j.jcv.2003.09.011 PMC 바로가기 [Article Type] Article