The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis
Research Article
[키워드] activated
Activation
Acute inflammation
ameliorated
appear
association
benefit
blocking
cascade
cause
CD45
characterized
clinical
complex
component
Control
deficiency
Deletion
disease
Disease progression
exacerbated
excessive inflammation
exhibited
experiment
expression
Fgl2
fulminant
Gr-1
Hepatic encephalopathy
Hepatitis
hepatocyte
high mortality
Host
IL-1β
inefficient
Infection
Inflammasome
Inflammatory
Inflammatory diseases
Inflammatory response
Intervention
knowledge
lack
life-threatening
limit
liver
Macrophage
macrophages
Mediated
mice
Mortality
murine hepatitis virus
NADPH
Necrosis
neutrophil
neutrophil infiltration
nicotinamide adenine dinucleotide
NLRP3
NLRP3 inflammasome
pathogen invasion
Pathogenesis
pathway
phosphate
Prevent
Protein
reactive oxygen specy
recruitment
reduce
reduced
reduction in
reductions in
Resilience
responsible
resulting
ROS
ROS production
secretion
serum
severe disease
severe liver disease
Signaling
signaling pathway
subsequent
subunit
syndrome
the disease
treated
Treatment
viral infection
virus infection
virus replication
wild-type
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article