Recombinant parainfluenza virus 5 vaccine encoding the influenza virus hemagglutinin protects against H5N1 highly pathogenic avian influenza virus infection following intranasal or intramuscular vaccination of BALB/c miceArticle Published on 2013-01-012022-10-06 Journal: Journal of Virology [Category] 진단, [키워드] administration Antigen approach approach BALB/c BALB/c mice booster contraindication different effectively controlled Efficacy ENCODE expressing H5N1 highly pathogenic immune responses immunization inactivated Infection Influenza Influenza virus intramuscular intramuscular vaccination intranasal lung mucosal IgA response Neutralizing New pandemic parainfluenza virus Prevent PROTECT Protective recombinant required robust serum antibody response shown single vaccine tested the vaccine threat vaccination Vaccine Vaccine development Vaccines virion Virology virus virus replication viruses while [DOI] 10.1128/JVI.02330-12 PMC 바로가기 [Article Type] Article
Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated SignalingResearch Article Published on 2012-02-012022-10-06 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute respiratory syndrome Antiviral block catalytic catalytically active Cell cells complex complexes contributing to coronavirus CoV Defense disrupting Disruption domain Endoplasmic reticulum evade expressing expression form found HCoV-NL63 Host IFN IKKε inactive Infected inhibit Innate innate immune innate immune response interferon MAVS mechanism membrane mutant NL63 nuclear translocation Papain-like protease PLP promoters Protein reduced regulate required response RIG-I SARS-CoV Signaling signaling molecule subsequent TBK1 wild type [DOI] 10.1371/journal.pone.0030802 PMC 바로가기 [Article Type] Research Article
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virusClinical Trial Published on 2010-05-112022-10-06 Journal: Proceedings of the National Academy of Sciences of [Category] 진단, [키워드] acquisition Administered Adult Adults Analysis antibody antiviral activity Antiviral effect assays clinical evidence concentrations decrease different double-blind Effectiveness enrolled exhibiting Factors healthy subject Human increase in independent Infected infected children Infection intranasal mechanism mRNA multiple logistic regression murine model nasal nasal washe nucleocapsid number of infected PCR Placebo placebo-controlled study placebo-controlled trial Proinflammatory cytokine proportion Protein protein expression Randomized recipient recipients representing respiratory syncytial virus RNA RSV RSV infection safety profile saline placebo significantly lower siRNA subjects tested therapeutic Therapeutic approach therapy treat uninfected unique viral culture was measured wild-type [DOI] 10.1073/pnas.0912186107 PMC 바로가기 [Article Type] Clinical Trial
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and SArticle Published on 2007-03-012022-10-06 Journal: Antiviral Research [Category] 진단, [키워드] accessory proteins acute respiratory syndrome aspecific assay coronavirus demonstrated Efficiency eight expressing expression full-length Genome genomic indirect immunofluorescence infected cell inhibit inhibition knockdown mRNA not affected nucleocapsid protein nucleotide Open reading frame ORF ORFs progeny Protein Proteins reduction in Replication RNA SARS CoV SARS-CoV sgRNA sgRNAs siRNA siRNAs specificity tested translated Vero E6 cell viral infection Viral protein virus were infected without affecting [DOI] 10.1016/j.antiviral.2006.10.008 PMC 바로가기 [Article Type] Article