ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure RegimensArticle Published on 2020-06-152023-05-23 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, Fulltext, [키워드] Antiviral agents clevudine HBV DNA Hepatitis B virus liver nucleoside analogs nucleotides phosphoramidate prodrug [DOI] 10.1128/AAC.00836-20 PMC 바로가기
Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19Review Published on 2020-06-132022-10-31 Journal: Cells [Category] COVID-19, [키워드] activated adverse effects amplification amplify antitumor agents Antiviral agents Antiviral treatment approved Autoimmune disorders biological processe Cancer Candidates Cell cell metabolism Clinical use clinically condition COVID-19 cycle Defense disease dose drug dysfunction Effect effective enzyme global pandemic Halogen Health HIV Human humans identify immune immune defense include Injury invading pathogen mechanism molecular mechanism NO signaling organism other diseases pathology phagocytosis physiological physiological functions plant produced Protective Radiation reaction reactive halogen species reactive nitrogen species reactive oxygen reactive oxygen species repeated required Research respiratory burst responsible RNS ROS SARS-CoV-2 Signaling signaling molecule Specy superoxide dismutases therapeutic efficacy Treatment Vaccine [DOI] 10.3390/cells9061461 PMC 바로가기 [Article Type] Review
Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)Article Published on 2020-06-102022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 25-Hydroxycholesterol acute respiratory syndrome addition AM580 animal model anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antigen expression Antiviral antiviral activity antiviral agent Antiviral agents caused Chloroquine clinical trials coronavirus COVID-19 evaluated exhibited expression in viral interferon interferons investigated Lipogenesis option pandemic Plaque reduction assay plaque reduction assays Potential Remdesivir Replication SARS-CoV-2 targeting the SARS-CoV-2 Treatment VeroE6 cell Viral antigen viral load reduction viruses [DOI] 10.3390/v12060628 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategiesArticle Published on 2020-06-102023-06-14 Journal: International journal of antimicrobial agents [Category] MERS, SARS, [키워드] Antiviral agents biosensor Chloroquine coronavirus SARS-CoV-2 Severe acute respiratory syndrome [DOI] 10.1016/j.ijantimicag.2020.106054 PMC 바로가기 [Article Type] Article
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication CycleAntiviral Agents Published on 2020-06-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] 50% effective concentration acute respiratory syndrome antiparasitic drug Antiviral agents antiviral drug benefit binding Calu-3 Cell Cell culture coronavirus COVID-19 COVID-19 patients cycle drug Drug repurposing epithelial epithelial cell line human lung human serum impacted Infection inhibit inhibited log pandemic performed Plaque reduction assay Prevent primary human airway progression provide public health randomized clinical trials Registered Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication step Suramin treat treated Vero E6 cell Viral load virus Wuhan, China [DOI] 10.1128/AAC.00900-20 PMC 바로가기 [Article Type] Antiviral Agents
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication CycleAntiviral Agents Published on 2020-06-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] 50% effective concentration acute respiratory syndrome antiparasitic drug Antiviral agents antiviral drug benefit binding Calu-3 Cell Cell culture coronavirus COVID-19 COVID-19 patients cycle drug Drug repurposing epithelial epithelial cell line human lung human serum impacted Infection inhibit inhibited log pandemic performed Plaque reduction assay Prevent primary human airway progression provide public health randomized clinical trials Registered Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication step Suramin treat treated Vero E6 cell Viral load virus Wuhan, China [DOI] 10.1128/AAC.00900-20 PMC 바로가기 [Article Type] Antiviral Agents
From Wuhan to COVID-19 Pandemic: An Up-to-Date Review of Its Pathogenesis, Potential Therapeutics, and Recent AdvancesReview Published on 2020-06-042022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] advance antiparasitic drug antiviral agent Antiviral agents approach Asymptomatic individuals Blood Chloroquine clinical trial conducted contagious coronavirus COVID-19 develop disease effective Evolution FDA-approved drug genomic sequencing in silico inactivation indicated investigated life-threatening molecular docking Novel coronavirus pandemic pathogen Pathogenesis pathogenicity Potential prevention public health recent recent finding respiratory tract infection review SARS-CoV-2 Scientific community shown survival therapeutic therapeutic advances Therapeutics Transmission Transmission routes Virtual screening Wuhan [DOI] 10.3390/microorganisms8060850 PMC 바로가기 [Article Type] Review
Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitroResearch Published on 2020-06-032022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] antiviral activity Antiviral agents antiviral effects antiviral strategy caused Combination combination treatment conserved contribute coronavirus effective epidemic diarrhea exhibited family Coronaviridae HCQ heptad repeat homoharringtonine Hydroxychloroquine in vitro Infection information inhibitor PEDV reduced Result short hairpin RNA TCID Treatment virus virus titer [DOI] 10.1186/s12985-020-01342-w PMC 바로가기 [Article Type] Research
Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South KoreaArticle Published on 2020-06-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory distress Admission age Antiviral agents antiviral therapy C-reactive protein Chronic kidney disease CKD Comorbidities condition consecutive patient Contact cough COVID-19 diagnosed Diagnosis dialysis died discharged Dyspnea early diagnosis elevated epicenter exhibited experience extracorporeal membrane oxygenation ferritin Hemodialysis hospital Hospitalization Hospitalized immune system infiltration inflammatory markers initiated laboratory-confirmed lymphopenia mechanical ventilation median men nine Older age one patient outcome outcomes Patient patients remained renal replacement therapy SARS-CoV-2 South Korea susceptibility Symptom symptom onset syndrome [DOI] 10.3390/jcm9061688 PMC 바로가기 [Article Type] Article
Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA VirusesReview Published on 2020-05-302022-10-28 Journal: Viruses [Category] COVID-19, [키워드] (+) ssRNA viruses Antiviral agents antiviral assay biosafety develop direct-acting antiviral Direct-acting antivirals drug Drug discovery Endemic genetic alteration genetics Health highlight include inhibitor inhibitors introduced Outbreaks Pathogens positive replicon replicon systems reporter responsible RNA SARS-CoV SARS-CoV-2 shown specific treatment ssRNA Still Vaccine viral infections viral replication virus West Nile Virus Zika virus [DOI] 10.3390/v12060598 PMC 바로가기 [Article Type] Review