Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide TypeArticle Published on 2016-11-282022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 229E acid Activation activities Alter amide amide bond anticancer Antioxidative antioxidative activity Antiviral antiviral activity binding Biological CAD Cell cell line chloride cinnamic acid derivative Compound compounds Concentration concentrations conjugate Conjugates coronavirus cytostatic activity derivative DPPH evaluated Evidence functional group Hela highest inhibitor inhibitory activity LOX MCF-7 morphology motif novel performed primaquine reducing reported selective spacer synthesis Type [DOI] 10.3390/molecules21121629 PMC 바로가기 [Article Type] Article
A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S방치된 항생제의 화학-유전체 검사에서 Kasugamycin 및 Blasticidin S의 불법적인 수송이 밝혀졌습니다Research Article Published on 2016-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] antibiotic Antibiotic resistance Antibiotics Antimicrobials approaches Bacteria Bacterial bacterial cell bacterial cells bacterial gene bacterial genes bacterial species biochemical blasticidin cells characterized compounds Critical determinant determinants determine disease E . coli Efficacy Escherichia coli Evidence Factor Fighting fire blight gene function Genetic genetic factors identify include investigated K-12 kasugamycin knowledge Loss mechanism microbe microbes Mutation Neglected open overlapping Pathogens peptide question reason reason for reduce Screen starting susceptibility targets these compound these compounds treat understanding [DOI] 10.1371/journal.pgen.1006124 PMC 바로가기 [Article Type] Research Article
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studiesResearch Article Published on 2015-04-282022-10-28 Journal: BMC Structural Biology [Category] Coronavirus, [키워드] 3CL 3CL pro 3CLpro binding compounds coronavirus coronavirus determine experimental validation generate homology homology model homology modelling Human Human coronavirus human coronavirus OC43 inhibit inhibited inhibitor inhibitors inhibitory effect Ligand molecular molecular dynamics OC43 other coronaviruses predicted protease provide receptor respiratory Result SARS-CoV shown stability Support was used [DOI] 10.1186/s12900-015-0035-3 PMC 바로가기 [Article Type] Research Article
Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replicationResearch Article Published on 2014-01-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Nigella sativa Rhodiola rosea Sambucus nigra Anti-viral drugs bronchitis Cell compounds Concentration coronavirus Cytopathic effect cytotoxicity derivative determined different Effect electron microscopy highest IBV infected cell Infection Infectious Bronchitis Virus inhibit magnitude mechanism of action membrane MOI multiplicity of infection Nigella Sativa non-infectious other coronavirus pathogenic plant Plaque assay Prevent protocol quantified reduced Replication Result Rhodiola Safe Sambucus solvent staining suggested supernatant tested tissue transmission electron microscopy treat treated Treatment trypan blue staining vaccination Vero Cell vesicles viral titer virion virus virus inhibition virus titer viruses [DOI] 10.1186/1746-6148-10-24 PMC 바로가기 [Article Type] Research Article
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids현장에서 포착된 퍼메트린 내성 Anopheles gambiae CYP6P3, 피레스로이드를 대사하는 P450 과발현Research Article Published on 2008-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. gambiae adaptive adaptive mechanism adaptive mechanisms Alpha alpha-cyano Anopheles gambiae anopheline mosquitoes Author bioassays compounds Critical CYP6P3 cytochrome P450 detect disease spread Efficacy ENCODE enzyme Enzymes Evolution facilitate found Frequency Gene Gene Expression Genetic Health health problem identify individual insect insecticide insecticides Insects involved lead low frequencies malaria malaria vector malaria vector control mechanism Messenger RNA Metabolic resistance metabolise Molecular assay molecular mechanism molecular mechanisms MONITOR natural selection overexpressed P450 pesticide pesticides phenotyped populations public health pyrethroid Pyrethroids receiving recessive allele reducing resistance significantly sub-Saharan Africa Survivors sustainability trait transcript level translated Transmission undergo [DOI] 10.1371/journal.pgen.1000286 PMC 바로가기 [Article Type] Research Article
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirusArticle Published on 2005-06-142022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] 2003 active against Antiviral antiviral activity antiviral agent Antiviral compounds antiviral drug antiviral potency assay automated be applied compounds coronavirus cytotoxicity demonstrated detect development Drug discovery EGFP expression evaluated Express facilitate fluorescent gastroenteritis Health High-throughput screening homogeneous inhibitor initial screening outbreak Protein risk SARS-CoV SARS-CoV infection severity specificity Spread therapeutic agent viral disease virus viruses [DOI] 10.1016/j.jviromet.2005.05.010 PMC 바로가기 [Article Type] Article