functions – Page 37 – Communicable Diseases Research

Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019

Review Article

Published on 2020-11-022022-10-28
Journal: Annals of Medicine [Category] COVID-19,

Unique fibrinogen-binding motifs in the nucleocapsid phosphoprotein of SARS CoV-2: Potential implications in host-pathogen interactions

SARS CoV-2의 뉴클레오캡시드 인단백질의 독특한 피브리노겐 결합 모티프: 숙주-병원체 상호작용의 잠재적 의미

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] SARS, 치료법,

[키워드] Asymptomatic binding Blood blood clot Blood clots blood clotting cascade clinical manifestation clinical manifestations clinical observation Coagulase Coagulation condition contagious Corona virus coronavirus COVID-19 Critical Critical illness death disease Disseminated intravascular coagulation Economy etiological agent evade fibrinogen function functions global health Health help homologous Host Host immune response host-pathogen interaction Hypothesis immune evasion implication in vitro incidence increase in increased risk induce infected patient infected patients infecting Infection information Interaction intravascular coagulation mechanism Mild molecular mechanisms morbidity and mortality motif Motif. N-protein novel Novel coronavirus nucleocapsid pandemic Potential Protein Proteins prothrombin regulate SARS CoV SARS CoV-2 SARS CoV-2 infection Stage Staphylococcus aureus tested therapeutic strategy turn unique virus von Willebrand factor
[DOI] 10.1016/j.mehy.2020.110030 PMC 바로가기 [Article Type] Article

Potential of electric stimulation for the management of COVID-19

COVID-19 관리를 위한 전기 자극의 가능성

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] 치료제,

Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019

Pharmacology

Published on 2020-10-292022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] addressed antiviral immune response antiviral response antiviral responses approach breadth Cell characterized clinical trial complications coronavirus coronavirus disease Coronaviruses COVID-19 Critical Cytokine storm detrimental effect environmental cues evaluated fibrosis functions HCoV-229E hypercoagulability Inflammatory responses initial interactions interferon signaling Lineage Macrophage macrophage phenotype MERS-CoV Numerous option pathogen clearance patients phenotype plasticity provided pulmonary fibrosis recruitment SARS-CoV SARS-CoV-2 targeting Therapeutic approach tissue repair variety viral infection while
[DOI] 10.3389/fphar.2020.577571 PMC 바로가기 [Article Type] Pharmacology

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

SARS-CoV-2의 진입 수용체인 지오텐신 전환 효소 2의 생물정보학적 특성화

Research Article

Published on 2020-10-282022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 mRNA age and gender Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 angiotensin-converting enzyme 2 binding site Bioinformatic bioinformatics caused Cell cell type cell types ciliary classical club COVID-19 COVID-19 epidemic duodenum endothelial entry receptor enzyme epithelial epithelial cells expressed expression functions Gene ontology analysis goblet goblet cells Health Organization highest immunohistochemistry include indicated interferon-stimulated response element International IRF8 IRF9 kidney lung Novel coronavirus novel coronavirus SARS-CoV-2 Ontology organ pandemic positive predict promoter promoters Protective public health emergency Regulation Renin renin-angiotensin system respiratory respiratory tract SARS-CoV-2 signal small intestine Stat1 suggested target cell target cells Testis Trachea transcription factor transcriptional regulation Vascular vessel World Health Organization
[DOI] 10.1371/journal.pone.0240647 PMC 바로가기 [Article Type] Research Article

The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19

Editorial

Published on 2020-10-272022-10-31
Journal: Nutrients [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress syndrome administration affecting Anti-inflammatory antioxidant Antithrombotic appear Ascorbate ascorbic acid carried China country COVID-19 Critically ill patient decrease decreased mortality deficiency Efficacy effort elevated Evidence functions greater group IMPROVE include indicated Intervention intravenous investigation low-middle-income monotherapy Mortality observational study optimization overlap oxidative stress Patient patients with COVID-19 patients with pneumonia physiological functions plasma pleiotropic Pneumonia Population prevention protocol Randomized controlled trial Randomized controlled trials RCT RCTs reduce Registered Research risk factor Risk factors role safety profile Sepsis severe coronavirus disease severe respiratory infections severely ill patient severity significantly sustained the disease translation Treatment Trial trials Vitamin Vitamin C with COVID-19
[DOI] 10.3390/nu12113286 PMC 바로가기 [Article Type] Editorial

Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database

Genetics

Published on 2020-10-272022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

[키워드] ACE2 ACE2 expression acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 antiviral drug BALF BALF cell Bronchoalveolar lavage fluid candidate candidate drug Cell cells clinical trial co-expressed connectivity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 database DEGs differentially expressed gene down-regulated gene drug effective expression functional enrichment functions gene cluster Genes healthy homologous identify immune defense immune dysfunction immune response indicated lung Map mechanism mRNA translation patients patients with COVID-19 performed positively correlated potential drugs public health crisis receptor reduce reflected regulatory agency Result RNA SARS-CoV SARS-CoV infection SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 synaptic transcriptome profile Transmission treat Treatment underlying mechanisms up-regulated Vaccine viral proliferation
[DOI] 10.3389/fgene.2020.558557 PMC 바로가기 [Article Type] Genetics

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses
[DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article

Insights into SARS-CoV-2, the Coronavirus Underlying COVID-19: Recent Genomic Data and the Development of Reverse Genetics Systems

Insight Review

Published on 2020-10-242022-10-30
Journal: The Journal of General Virology [Category] COVID-19, MERS, SARS,

Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?

Article

Published on 2020-10-222022-10-29
Journal: Turkish Journal of Medical Sciences [Category] COVID-19, MERS, SARS,