Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan연령, 성별 및 암은 아니지만 신경퇴행성 및 심혈관 질환은 수명에 대한 아포지단백 E4 대립유전자의 전신 효과를 강력하게 조절합니다Research Article Published on 2014-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adverse effect age allele Analysis ApoE APOE gene ApoE4 allele ApoE4 carrier APOE4 carriers Apolipoprotein Apolipoprotein e association Author Cancer cardiovascular cardiovascular and neurodegenerative diseases cardiovascular disease carriers Cohort cohorts compared CVD death deaths disease Diseases e4 allele e4 allele carrier e4 allele carriers e4 carrier e4 carriers Effect Enduring ENhance explain extreme family Family Study genetic origin genetic origins genotyped ApoE polymorphism Geriatrics Gerontology healthy heart Human human disease human diseases increase interfere large sample lead life Life expectancy lifespan Long Longitudinal studies Major mechanism mechanisms men moderate Mortality neurodegenerative neurodegenerative disorder neurodegenerative disorders Non-skin cancer offspring old ages participant polymorphism Population populations Relative risk resulting risk risk of death sensitivity skin cancer survival systemic women [DOI] 10.1371/journal.pgen.1004141 PMC 바로가기 [Article Type] Research Article
Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum LevelsAlpha1-항트립신 혈청 수준이 있는 SERPINA 유전자 클러스터의 변이체의 인과적 및 합성적 연관성Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated allele Alpha1-antitrypsin Analysis antitrypsin association Author Blood Causal chromosomal locus chronic obstructive chronic obstructive pulmonary disease circulating city Cohort common variants complex Concentration contribute COPD deficiency defined Degradation determined driven by Effect emphysema enzyme examined example explained functional gene cluster General population Genetic genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms Genetic variant Genome-wide association study genome-wide significance genotyped genotyping GWAS Health heart hidden independent individual inhibitor Level locus Lung function MAF MAFs Meta-analysis minor allele frequency nucleotide obstructive pulmonary disease participant phenotype PI polymorphism PROTECT Protein pulmonary disease pulmonary tissue reached reduce replicated Replication respiratory risk risk factor SERPINA1 SERPINA1 gene Serum level serum levels Single nucleotide polymorphism single nucleotide polymorphisms Smokers SNP SNPs subsequent suggested Support synthetic tissue transfer Variability variant variants while [DOI] 10.1371/journal.pgen.1003585 PMC 바로가기 [Article Type] Research Article
Long-term Mortality in Adult Orthotopic Heart Transplant RecipientsOriginal Article Published on 2011-05-212024-09-04 Journal: Journal of Korean medical science [Category] 대상포진, [키워드] death heart transplantation [DOI] 10.3346/jkms.2011.26.5.599 PMC 바로가기 [Article Type] Original Article