monocyte – Page 37 – Communicable Diseases Research

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Article

Published on 2020-08-062022-10-04
Journal: Nature Communications [Category] MERS, 임상, 치료법, 치료제,

Poor Prognostic Biochemical Markers Predicting Fatalities Caused by COVID-19: A Retrospective Observational Study From a Developing Country

Internal Medicine

Published on 2020-08-052022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome Admission age Analysis biochemical marker Biomarker Biomarkers C-reactive protein Cell conducted coronavirus coronavirus disease Course COVID-19 COVID-19 positive patient creatinine CRP CRP level D-dimer D-dimer level Developing discharge disease effective elevated fatality female patient ferritin Health hemoglobin hospital hypernatremia IBM identify Infectious diseases intensive care Isolation Laboratory laboratory investigation lactate dehydrogenase LDH leukocyte Leukocytosis Lymphocyte count lymphocytopenia male marker material monocyte Mortality neutrophil count non-survivor outcome Pakistan pandemic Patient patients patients died PCT Platelet Poor Predictive procalcitonin Prognosis receiver operating characteristic recovered patients Result resulting retrospective SARS-CoV-2 serum severity shown significant difference significantly significantly increased sodium SPSS Statistics study population survived survivor the disease urea Version Volume was done window World Health Organization
[DOI] 10.7759/cureus.9575 PMC 바로가기 [Article Type] Internal Medicine

Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis

Review

Published on 2020-08-032022-10-31
Journal: European Journal of Medical Research [Category] COVID-19, MERS,

[키워드] 95% confidence interval alanine aminotransferase albumin ALT article Asian Aspartate aminotransferase AST Blood urea nitrogen C-reactive protein China CIs clinician COVID COVID-19 COVID-19 patient creatine creatinine CRP D-dimer database Disease progression eosinophil ESR Evidence feature fibrinogen finding fixed Future Glucose Google Scholar help hemoglobin Hospitalized ICU admission IL-6 increase in infected case kinase Laboratory laboratory feature Laboratory features lactate dehydrogenase LCR LDH leukocyte lymphocyte mean difference Meta-analysis monocyte Myoglobin neutrophil NLR non-severe group non-severe patient Patient PCT Platelet Population predict Prothrombin time provide Rate searched sedimentation serum sodium Severe case severe group significant changes in significant decrease Singapore standardized mean difference systematic review total bilirubin troponin I two group understanding was determined WBC Web of Science White blood cell
[DOI] 10.1186/s40001-020-00432-3 PMC 바로가기 [Article Type] Review

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

Pharmacology

Published on 2020-07-292022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE2 Alpha alveolar cell antagonists Apoptosis AT1 biological marker blockade blockers capillary leakage CDK9 Cell cellular and molecular chemotactic clinical feature clinical marker contribute COVID-19 COVID-19 immune response CRP cytokine release Cytokine storm Cytokines cytoplasmic Defense Degradation Dexamethasone differentiation Diffuse alveolar damage downstream signaling pathway doxycycline element elevated elevated lactate dehydrogenase entry of SARS-CoV-2 epithelial estrogen receptor expression IL-17 IL-6 immune immune response Immunity include infiltration Inflammatory Inflammatory cytokine inflammatory cytokine production inflammatory signaling inhibitor initial Injury interferon response Intervention Ivermectin Jak kinase inhibitors LDH lung tissue MAPK mechanism melatonin membrane fusion membrane-bound molecular monocyte monocyte-derived macrophage NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil-to-lymphocyte ratio NF-κB NLR p65 pathogenic pathophysiology pathway Platelet Pneumocytes Point Potential pro-inflammatory promote Prophylaxis provoke receptor reduce Remdesivir Research respiratory epithelia respiratory epithelial cells SARS-CoV-2 coronavirus selective Signal transduction skewed subtype T-cell therapeutic interventions therapeutic response Therapeutics thrombosis TNF-α type I interferons type III Vascular Viral load virus
[DOI] 10.3389/fphar.2020.01169 PMC 바로가기 [Article Type] Pharmacology

COVID-19: immunopathogenesis and Immunotherapeutics

Review Article

Published on 2020-07-252022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상,

[키워드] Abnormalities abnormality activate acute respiratory syndrome Anti-viral immunity antiviral immune responses appear caused characterized clinical implication Clinical management clinical manifestations coronavirus COVID-19 Critical disease pathogenesis dysfunction granulocyte Host immune response immune immune response Immunopathogenesis immunopathology Immunotherapy include infected patient Infection Infectious diseases Inflammatory response inhibiting lymphocyte lymphopenia management mechanism microorganisms monocyte multiple organ dysfunction novel coronavirus disease outbreak Patient patients with COVID-19 potential mechanisms pro-inflammatory cytokine release rapid increase SARS-CoV-2 Septic shock severe COVID-19 systemic inflammation the disease therapeutic strategy Treatment
[DOI] 10.1038/s41392-020-00243-2 PMC 바로가기 [Article Type] Review Article

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Article

Published on 2020-07-172023-06-18
Journal: Cell Metabolism [Category] Fulltext, SARS,

[키워드] COVID-19 diabetes Glycolysis HIF-1alpha Inflammation interferon metabolism Mitochondria monocyte SARS-CoV-2
[DOI] 10.1016/j.cmet.2020.07.007 PMC 바로가기

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Article

Published on 2020-07-072022-11-01
Journal: Cell Research [Category] COVID-19, MERS, SARS,

[키워드] 2019 novel coronavirus candidate vaccine cause characterized demonstrated edema evaluate Genome-wide association studies Infection infiltration interstitial pneumonia lung lung; lymphocyte Mild monocyte mortality rate neutralizing antibody non-human primate model Novel coronavirus observation occurred oropharyngeal swab oropharyngeal swabs outbreak platform Pneumonia post infection Primary infection PROTECT provide public health reflected Replication respiratory tract respiratory tract tissues rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RNA severe cases susceptible viral infection Viral RNA virus Whole genome amplification World Health Organization
[DOI] 10.1038/s41422-020-0364-z PMC 바로가기 [Article Type] Article

Coronavirus disease 2019 induces multi‐lineage, morphologic changes in peripheral blood cells

Research Article

Published on 2020-06-292022-10-31
Journal: Ejhaem [Category] COVID-19,

[키워드] acute respiratory distress Analysis analyzed Blood blood differential count caused change changes in characteristic Clinical course coagulation disorder Cohort conducted coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical defined diagnostic electron microscopy erythropoiesis exhibited facilitate flow cytometry hemato‐morphology hematologic hyperinflammation independent induce intensive care light microscopy lymphocyte median age Microscopy Mild symptom monocyte patients Peripheral blood peripheral blood cell peripheral blood smear SARS‐CoV‐2 severely ill patients syndrome was performed
[DOI] 10.1002/jha2.44 PMC 바로가기 [Article Type] Research Article

Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels

Research Paper

Published on 2020-06-272022-10-29
Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 expression activate activating Activation acute respiratory distress addition agonist analyzed angiotensin-converting enzyme 2 ARDS bioinformatics cell line cell lines Chest CT images clinical evidence clinical parameter clinician Cohort country COVID-19 COVID-19 cases Critical Critical case Cytokine storm Dexamethasone digestive system digestive tract dose drug Drug repurposing Effect effective Efficacy engage epithelial cell line glucocorticoid Glucocorticoids IL-6 IL-6 level IMPROVE inhibit Macrophage medium Methylprednisolone molecular target monocyte Mortality nine Patient Prednisolone protective role provide public health emergency reducing regions riboside SARS-CoV-2 screened spread to syndrome therapeutic therapeutic efficacy THP-1 Treatment treatment regimen Wuhan
[DOI] 10.7150/ijbs.47652 PMC 바로가기 [Article Type] Research Paper

Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of Karachi

Internal Medicine

Published on 2020-06-202022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome Admitted Patient affecting age Aspartate aminotransferase AST Bilateral C-reactive protein (CRP change Characteristics chest radiographic clinical Clinical characteristics Comorbidity coronavirus country COVID-19 creatinine death diabete disease severity dry cough evaluated Factor Fever global pandemic Hospital stay hospitalized patient hypertension ICU ICU admission ICU Patients indicators indices intensive care unit Karachi laboratory investigation lactate dehydrogenase LCR LDH leukocyte lymphocyte markers material monocyte mortalities Mortality neutrophil Neutrophil-to-lymphocyte ratio NLR Pakistan pandemic patchy patients PCR polymerase chain positive Positive predictive value profile Prognosis Protein reported Result severity significant difference Symptom Tertiary the patient urea viral disease zone
[DOI] 10.7759/cureus.8712 PMC 바로가기 [Article Type] Internal Medicine