Chest pain and high troponin level without significant respiratory symptoms in young patients with COVID-19Case Report Published on 2020-01-012022-10-31 Journal: Caspian Journal of Internal Medicine [Category] COVID-19, [키워드] Acute coronary syndrome Acute myocarditis baseline cardiovascular risk factor chest pain conditions coronary syndrome COVID-19 COVID19 CT scan described Diabetes Mellitus discharged disease severity Follow-up help Hospital stay infected with COVID-19 Infection lab marker mild symptoms myocardial injury Pain Patient patients with COVID-19 poor prognosis presenting rRT-PCR significant respiratory symptom significant respiratory symptoms smoking suggested troponin levels [DOI] 10.22088/cjim.11.0.561 PMC 바로가기 [Article Type] Case Report
Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antiviralsC형 간염 바이러스는 직접 작용하는 항바이러스제에 의한 감염 치료 후 후성 유전적 특징을 남깁니다.Research Article Published on 2019-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Alter alteration Anti-HCV Antiviral approach Biomarker Cell cells change changes in characterized Chemotherapy ChIP-seq chromatin chromatin immunoprecipitation chronic hepatitis develop direct-acting antiviral disease drug Effect EGFR EGFR Inhibitor enzyme Epidemiological study Epigenetic Erlotinib Europe expected explain expression followed by gene signature Genome HCC HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma histone Hit and run host gene expression identify in vitro induce infected case infected patient Infection inhibit inhibitor interferon life cycle liver Liver Biopsy marker mechanism Modification molecular mechanism Mortality Multiple Multiple epidemiological studies Next-generation sequencing observation offer oncogenic outcome Pathogenesis pathogenic Pathways Patient persist poor prognosis post-translational modification predominant Prevalence proceed replaced repressed risk risk factor RNA signaling pathway specific inhibitor specific inhibitors sustained the cells therapeutic target therapy Treatment Tumor unmet need Viral protein Viral proteins virological response virus while [DOI] 10.1371/journal.pgen.1008181 PMC 바로가기 [Article Type] Research Article
Factors associated with recovery delay in a sample of patients diagnosed by MERS ‐CoV rRT ‐ PCR : A Saudi Arabian multicenter retrospective studyOriginal Article Published on 2018-04-252022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] Coronavirus, MERS, [키워드] MERS‐CoV adjusted relative risk aRR calculated Camel camel contact clinical decision clinical recovery conducted Contact diagnosed Diagnosis diagnosis delay estimate Evidence Factor help hospital resource ICU admission identify Infection initial interval median MERS Middle East multicenter objective Older age Patient patients PCR PCR assay poor prognosis positive recovery delay respiratory symptom respiratory syndrome coronavirus Result Retrospective study Support time interval Treatment strategies [DOI] 10.1111/irv.12560 PMC 바로가기 [Article Type] Original Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article