The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of ChickensCommunication Published on 2018-11-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] activating avian macrophage Bacterial CD4+ CD4+ cell CD8α+ cell chicken Cluster CpG CpG oligonucleotide days post infection delivery determine embryonic IBV IBV infection immune response In ovo Infectious Bronchitis Virus interferon lung macrophages mechanism morbidity and mortality mRNA oligonucleotide PROTECT protective effect recruitment reduce reduced respiratory respiratory tract shown signaling pathway significantly higher survival rate T lymphocytes Toll-like receptor tract viral infections [DOI] 10.3390/v10110635 PMC 바로가기 [Article Type] Communication
Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodiesArticle Published on 2017-09-072022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] age antibody assigned caused Cell Clinical sign clinically conditions epidemic diarrhea Europe European group healthy help induce inoculated MDA morbidity naïve Occurrence offspring outbreak Outbreaks PEDV pregnant Prevent protective effect Randomly reported specific antibody strain subset the United State Trial vaccination virulence virus were assessed [DOI] 10.1038/s41598-017-11160-w PMC 바로가기 [Article Type] Article
High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in pigletsResearch Article Published on 2014-03-282022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] added addition Apoptosis cause chloride Concentration control group coronavirus cytokine decrease detectable diarrhea Diseases down-regulation Electrophysiology epithelial evaluate the effect fecal Fecal consistency Final gastroenteritis group groups humoral immune response IFN in vivo incidence Infection interferon intestinal intestinal tract mechanism mitigate Morphometry mucosal immune OAS oral physiological PROTECT protective effect receiving reduce response Result secretion serum antibody response severity shown SLC30A1 SLC30A5 SLC39A4 stimulate TGEV three group transmissible gastroenteritis virus villus virus virus infection was performed Zinc zinc oxide Zinc transporters [DOI] 10.1186/1746-6148-10-75 PMC 바로가기 [Article Type] Research Article
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?Article Published on 2009-04-182023-08-30 Journal: Journal of Clinical Virology [Category] E형 간염, [키워드] acute respiratory tract infection Innate immunity Interference protective effect rhinovirus [DOI] 10.1016/j.jcv.2009.03.008 PMC 바로가기 [Article Type] Article
Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control studyResearch Article Published on 2008-02-292022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 95% CI acute respiratory syndrome adjusted Analysis association carried case-control study collected data compared conducted cured determine discharged fibrosis found Genetic polymorphism Genotype glucocorticoid Health care worker healthy controls Host genetic factor Infection interstitial locus Logistic lung Lung fibrosis manifested Necrosis not affect Occurrence PCR polymorphism prognosis of patient promoter region protective effect relationship Result risk risk factor role SARS patient SARS patients SARS-CoV infection Sequencing SNP susceptibility TNF TNF-α was used [DOI] 10.1186/1471-2334-8-27 PMC 바로가기 [Article Type] Research Article
Long-term Psychological and Occupational Effects of Providing Hospital Healthcare during SARS OutbreakResearch Published on 2006-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome adverse outcome adverse outcomes affected Burnout Burnout, Professional, research consequence Contact Effect effective explained Factors found HCW HCWs Health personnel healthcare worker hospital occupational outbreak Outbreaks Patient Posttraumatic Stress protective effect Providing Psychological Psychological distress reduced reported SARS patient Severe acute respiratory syndrome significantly higher Stress Stress, psychological Stress, Traumatic Support Toronto treat treated variance [DOI] 10.3201/eid1212.060584 PMC 바로가기 [Article Type] Research