Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinomaResearch Article Published on 2021-03-082023-06-03 Journal: Clinical and Translational Medicine [Category] B형 간염, Fulltext, [키워드] Hepatocellular carcinoma histone lysine acetylation Prognostic factor proteomics [DOI] 10.1002/ctm2.313 PMC 바로가기 [Article Type] Research Article
Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET StudyProtocol Published on 2021-03-042022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] adaptive Analysis analyzed approved biochemical tests Biomarker Biomarkers blood sample Care clinical clinical information Coagulation Cohort collected Committee Complete consequence COVID-19 COVID-19 pandemic cytokine profile cytokine release deaths demographic characteristics design enrolled Ethics expected form Gene Expression genetics Health Hemostasis Human human host Identifier immune immune system immune systems Immunoglobulin immunology Inclusion Inflammation information knowledge leukocyte metabolomics Migration Mild Neutralizing antibodies Neutrophil extracellular trap neutrophil function objective parameter Patient patients with COVID-19 phagocytosis polymerase chain Prognosis Prospective proteomics reactive oxygen recruitment Registration registry report Result reverse transcription robust severe patients target the SARS-CoV-2 virus Thromboelastometry virus [DOI] 10.2196/24211 PMC 바로가기 [Article Type] Protocol
The Multifaceted Role of Protein Phosphatase 1 in Plasmodiumarticle Published on 2021-02-282024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] interactome phosphatases Plasmodium PP1 proteomics regulatory subunits [Article Type] article
SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection초기 비인두 감염에서 SARS-CoV-2 선천적 이펙터 연관성 및 바이러스 부하Observational Study Published on 2021-02-242022-09-01 Journal: Physiological Reports [Category] MERS, 임상, 진단, [키워드] 95% CI ACE age ambulatory Antiviral antiviral gene antiviral protein antiviral responses applied association Biomarkers blocked BST cause Chain Reaction change characterized clinical outcomes clinical testing COVID‐19 cytokine Cytokines discrepancy disease disrupt early disease Effects elevated Evidence evidence of examined Host host shut‐off Hypothesis IFIT1 IFIT3 IFN IFN‐γ immune immune responses immunoassays individual Infection Inflammatory cytokines innate immune innate immune response innate immune responses Innate immunity interferon interferons ISG Modification multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Older age outcomes Patient polymerase chain polymerase chain reaction polymerase chain reaction assays Proinflammatory cytokine Protein proteomics Quantitative responses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease subsequent Symptom symptomatic patient systemic inflammatory tested transcribed transcript Transcription transcripts translated translation university Utah Viral viral infection Viral load widespread with infection [DOI] 10.14814/phy2.14761 PMC 바로가기 [Article Type] Observational Study
Omics-Driven Biotechnology for Industrial ApplicationsBioengineering and Biotechnology Published on 2021-02-232022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] application approaches biological system Biotechnology COVID-19 research experiment experiments Genomics highlight Industrial metabolic engineering metabolomics Multi-omics proteomics robust Systems biology transcriptomics [DOI] 10.3389/fbioe.2021.613307 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Circulating Exosomes Are Strongly Involved in SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-02-222022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Activation addition Analysis approach AUC Biomarker Biomarkers C1r circulating Coagulation complement complement pathways component Course COVID-19 pathogenesis diagnostic Disease progression disease severity Exosome extracellular vesicle fibrinogen Host host cell host response host-response immune response Infection Inflammation investigated involved main mechanism modulate novel coronavirus SARS-CoV-2 organ dysfunctions plasma plasma exosomes presenting proteomic proteomics SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum amyloid shown Spread Therapeutic strategies tissue damage viral infection virus [DOI] 10.3389/fmolb.2021.632290 PMC 바로가기 [Article Type] Molecular Biosciences
Biomarker Discovery of Acute Coronary Syndrome Using Proteomic ApproachArticle Published on 2021-02-202023-08-30 Journal: Molecules [Category] E형 간염, [키워드] Acute coronary syndrome Biomarker Diagnosis proteomics [DOI] 10.3390/molecules26041136 PMC 바로가기 [Article Type] Article
20S proteasomes secreted by the malaria parasite promote its growth말라리아 기생충이 분비하는 20S 프로테아좀은 그 성장 촉진에 기여한다.Article Published on 2021-02-192024-08-08 Journal: Nature Communications [Category] 말라리아, [키워드] Parasite host response proteasome proteomics [DOI] 10.1038/s41467-021-21344-8 PMC 바로가기 [Article Type] Article
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9Research Published on 2021-02-182023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] Influenza virus Mitochondria proteomics Two-dimensional electrophoresis [DOI] 10.1186/s12985-021-01512-4 PMC 바로가기 [Article Type] Research
MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid proteinResearch Paper Published on 2021-02-062022-10-28 Journal: Theranostics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Betacoronavirus C-terminal domain can be used Cell co-immunoprecipitation conducted coronavirus Coronaviruses determine develop envelope protein homology immunostaining in vitro infected cells inhibit inhibited Interaction investigated Lineage MERS-CoV MERS-CoV-infected cells Middle East molecular interaction N protein N proteins nucleocapsid nucleocapsid protein penetration peptide produced Protein proteomics Replication respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells spike Spike protein Strains synthetic peptide targeting the N protein the S protein the SARS-CoV-2 the Spike Viral protein viral spike protein virus virus infection virus production virus replication [DOI] 10.7150/thno.55647 PMC 바로가기 [Article Type] Research Paper