Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in BangladeshOriginal Paper Published on 2020-10-292022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] 95% CI age AOR CHD Chronic kidney disease chronic liver disease chronic obstructive CKD CLD Cohort collected Comorbidity conducted COPD Coronary heart disease coronavirus disease Course COVID-19 COVID-19 patient COVID-19 patients Diabetes Mellitus diagnosed Factor hypertension identify Intervention Major majority male malignant disease morbidity morbidity and mortality mortality and outcomes mortality rate mortality risk non-survivor outcome outcomes Patient proportion pulmonary disease questionnaire retrospective cohort study risk risk factor Risk factors smokeless the disease the patient urban [DOI] 10.1017/S0950268820002630 PMC 바로가기 [Article Type] Original Paper
Does Nicotine Prevent Cytokine Storms in COVID-19?Psychiatry Published on 2020-10-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] affective age alcohol alpha-7-nach receptor Anti-inflammatory bipolar affective disorder boost Cholinergic anti-inflammatory pathway chronic obstructive chronic obstructive pulmonary disease cigarette smoking Comorbidity contributed COVID-19 COVID-19 complications death disorder excessive use manic multiple comorbidities Nicotine nicotine replacement therapy outcome pathway pro-inflammatory cytokine pro-inflammatory cytokines pulmonary disease receptor Respiratory Support risk factor SARS-CoV-2 Sepsis severe COVID-19 smoking specific treatment storm the SARS-CoV-2 virus therapy Treatment triggered [DOI] 10.7759/cureus.11220 PMC 바로가기 [Article Type] Psychiatry
“Early transfusion of convalescent plasma in older patients with COVID-19 to prevent disease progression: A structured summary of a study protocol for a randomised controlled trial”Letter Published on 2020-10-222022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 ABO accompany addition Adult patient adverse event age anti-SARS-CoV-2 antibody Antibody titer anticipated blood product Cardiopulmonary CCP CDC Comorbidities Comorbidity conducted convalescent plasma COVID-19 COVID-19 pneumonia patient criteria decrease Decreased defined disease dissemination dose elderly element eligible for inclusion hospital Identifier IgA increase Increased information investigator IRCCS Italy Length life-threatening Nasopharyngeal swab number objective older patient Open-label outcome paO2/fiO2 parallel group participant Patient performed phase plasma Pneumonia positive Prevent proceed progression protocol pulmonary disease randomised randomised controlled randomised controlled trial Randomized receive recipients recruitment refusal Registered risk SAE Sample size SARS-CoV2 secondary Secondary objective sequence severe pneumonia severity Sex Standard Standard therapy status Stratification Study protocol the patient therapy titre Total Trial two-tailed Viral load Viremia website WHO with COVID-19 worsening [DOI] 10.1186/s13063-020-04821-1 PMC 바로가기 [Article Type] Letter
The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: A structured summary of a study protocol for a randomised controlled trialCOVID-19 환자의 치료 보조제로 커큐민을 함유한 나노 미셀의 임상 효과 및 치료 후 면역 반응 균형 변화: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-10-222022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 accompany addition allergy assigned balance Bandar Abbas bedtime blind Blinding both groups breakfast Capsule change Characteristics chronic chronic obstructive pulmonary disease clinical Clinical effect clinical examination clinical examinations clinical symptom clinical trial clinical trials Comorbidities Comorbidity company comparator Complete computer conducted congestive heart failure control group COVID-19 COVID-19 patient COVID-19 patients Curcumin Cytokines digit digits dinner dissemination Effectiveness element evaluate evaluated expected expression filtration filtration rate FOXP3 gallstone gastritis GATA Gender Gene Expression glomerular filtration rate heart failure history IFN-γ IL-17 IL-4 immune response immune responses in both group inclusion criteria Inflammatory marker inflammatory markers information Interleukins intervention group Iran kPa Laboratory laboratory findings laboratory technician laboratory technicians lactation less liver liver failure Lymphocytes number Nurses objective Obstructive obstructive pulmonary disease outcome PaO2 parallel group participant Participation Patient patients patients with COVID-19 per day performed Peripheral blood physician Placebo placebo group placebo-controlled positive COVID-19 post treatment Pregnancy protocol pulmonary disease random randomisation randomised randomised controlled trial randomization Randomized randomized clinical trial Randomly real time PCR recorded recruitment Registered registry Regulatory renal renal failure routine standard treatment Sample size sealed selected serum cytokine serum cytokines Serum level serum parameter serum parameters shift single-center statisticians Study protocol T helper TGF-β the placebo group therapeutic Treatment Trial Trial registration ventilator Version website written consent [DOI] 10.1186/s13063-020-04824-y PMC 바로가기 [Article Type] Letter
Sex differences in clinical phenotype and transitions of care among individuals dying of COVID-19 in ItalyResearch Published on 2020-10-162022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, MERS, SARS, [키워드] 95% CI Acute kidney injury acute respiratory illness Admission Analysis analyzed Autoimmune disease both sexes Care Characteristics Chronic kidney disease chronic obstructive clinical clinical feature clinical manifestation clinical phenotype Comorbidities coronavirus disease COVID-19 COVID-19-related death death Deceased Dementia different clinical manifestation disease explain feature Fever Hospitalized identify identifying in-hospital complications individual individuals with COVID-19 ischemic heart disease Italy laboratory-confirmed SARS-CoV-2 infection Male sex men Multimorbidity Nasopharyngeal swab occurred Older outbreak outcome Prevalence progression pulmonary disease Result Retrospective analysis Sex Sex difference susceptibility therapy Transition of care was performed with COVID-19 women [DOI] 10.1186/s13293-020-00334-3 PMC 바로가기 [Article Type] Research
Development and validation of a prediction model for early identification of critically ill elderly COVID-19 patientsResearch Paper Published on 2020-10-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] Admission age AUC calibration plots characteristic China chronic obstructive Cohort cohorts coronavirus disease cough COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient development elderly patients examined external validation fatigue Fever goodness-of-fit test high risk increased risk individual laboratory-confirmed lymphocyte patients Prediction model proportion pulmonary disease Shortness of breath Symptom validation cohort [DOI] 10.18632/aging.103716 PMC 바로가기 [Article Type] Research Paper
The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic PotentialsArticle Published on 2020-10-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Hibiscus noldeae Acetate Activation activities acute respiratory syndrome anti-inflammatory effect Asthma Autoimmune diseases Baker bio-guided fractionation caffeic acid caspase-1 chronic obstructive component Compound Constituent controls COPD coronavirus downregulated Evidence fraction functional headache Hibiscus IL-1β IL-1β IL-6 Inflammasome Inflammatory inhibition inhibitor inhibitory inhibitory effect interleukin interleukin 6 lipopolysaccharide LPS Macrophage macrophages molecular mouse macrophages NLRP3 NLRP3 inflammasome Potential Production protein 3 pulmonary disease purified RAW264.7 reported Respiratory disease supported THP-1 Treatment variety was determined widespread [DOI] 10.3390/molecules25204693 PMC 바로가기 [Article Type] Article
South African Thoracic Society statement on obstructive airways disease and COVID-19Guideline Published on 2020-10-132022-10-28 Journal: African Journal of Thoracic and Critical Care Medicine [Category] COVID-19, [키워드] African airway airways disease assist Asthma chronic clinician COPD Corticosteroid Corticosteroids COVID-19 disease Ensure Epidemic Face mask Guidance hygiene impaired lung function Influenza inhaled corticosteroid International Local maintenance measure mechanical ventilation medication Novel coronavirus Obstructive occur outcomes outlined Patient pneumococcal infection precautions pulmonary disease Respiratory failure SARS-CoV-2 severe COVID-19 disease severe respiratory infection social distancing Society South South Africa susceptibility uncontrolled withdrawn worsened [DOI] 10.7196/AJTCCM.2020.v26i3.111 PMC 바로가기 [Article Type] Guideline
Clinical and laboratory data, radiological structured report findings and quantitative evaluation of lung involvement on baseline chest CT in COVID-19 patients to predict prognosis임상 및 실험실 데이터, 방사선학적 구조화된 보고서 결과 및 예후 예측을 위한 COVID-19 환자의 기준 흉부 CT에서 폐 침범의 정량적 평가Chest Radiology Published on 2020-10-122022-09-01 Journal: La Radiologia Medica [Category] MERS, SARS, 진단, [키워드] Accuracy addition Admission age ALT artificial intelligence AST azotemia baseline Bilirubin calculate Chain Reaction Chest CT chest CT examination Chest CT image Chest CT images clinical Combination Comorbidities Comorbidity condition Consensus consolidation consolidations COVID-19 COVID-19 disease COVID-19 patient COVID-19 pneumonia creatinine critical condition CRP CT finding CT findings D-dimer died dimer discharged disease distribution emphysema evaluate evaluated GGO Ground-glass opacities ground-glass opacity healthy highest Hospitalized Hounsfield unit independent predictor independent predictors Laboratory laboratory data laboratory findings LDH leukocyte lobe lung lung involvement lung parenchyma Lungs material multivariate regression analysis Neutrophils not affect objective outcome Patient patients patients hospitalized patients with COVID-19 performed Pneumonia polymerase chain polymerase chain reaction predict Prognosis pulmonary disease quantification Quantitative R 2 radiological Radiologists regression analysis Regression model regression models Result reverse transcription RT-PCR scoring system sensitivity severity Severity Score significantly higher significantly lower specificity SpO2 statistically significant statistically significant difference suspicious COVID-19 the patient Thoracic three group three groups troponin Viral viral infection Volume was obtained was performed women [DOI] 10.1007/s11547-020-01293-w PMC 바로가기 [Article Type] Chest Radiology
Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving HospitalInternal Medicine Published on 2020-10-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour 24 hours 95% CI 95%CI Administered age analyzed chi-square test chronic obstructive co-morbid conditions co-morbidities co-morbidity Comorbidities Comparative COVID-19 cross-sectional determine diabete Diabetes Mellitus Frequency Gender hypertension IBM ICU IMV independent risk factor independent t-test intensive care Invasive mechanical ventilation less likelihood LOS Major Mortality mortality rate multivariable multivariate regression analysis NIV not affected objective overall mortality Patient patients predict pulmonary disease Result retrieved severe COVID-19 SPSS survival survivor the mean variable variables Ventilation ventilatory was used were used [DOI] 10.7759/cureus.10906 PMC 바로가기 [Article Type] Internal Medicine