Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injuryCOVID-19 관련 심근 손상 환자의 좌심실 및 우심실 기능 장애Original Paper Published on 2021-01-302022-09-10 Journal: Infection [Category] MERS, SARS, 유전자 메커니즘, [키워드] absence baseline biventricular dysfunction characterisation Concomitant Course COVID-19 defined develop disease dysfunction echocardiographic echocardiography Ejection fraction elevated Follow-up Global longitudinal strain GLS heart failure hospitalised Infection left LV dysfunction Morphological Munich Myocardial dysfunction myocardial injury pandemic pathophysiological mechanism pathophysiological mechanisms Patient patients presence or absence preserved reduced registry resolved Result RV dysfunction SARS-COV-2 infection significantly supplementary material Three-dimensional echocardiography Trial troponin T university ventricular ventricular dysfunction ventricular ejection was impaired WHO with COVID-19 [DOI] 10.1007/s15010-020-01572-8 PMC 바로가기 [Article Type] Original Paper
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational StudyMedicine Published on 2021-01-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 28-day mortality acute respiratory distress syndrome age Analysis baseline Biomarker Brazil clinical Clinical improvement conducted convalescent plasma coronavirus coronavirus disease COVID-19 COVID-19 patient Critically ill patient disease Effect Efficacy Final Follow-up hazard ratio IgG titer Ill increase in inflammatory activity IQR Kaplan–Meier laboratory-confirmed life-threatening Lymphocyte count mechanically ventilated occurred outcome Patient patients performed plasma prospective observational study reduced Registered registry Respiratory failure Rio de Janeiro secondary single-center Standard of care Study protocol survival therapeutic option viral loads with COVID-19 [DOI] 10.3389/fmed.2021.630982 PMC 바로가기 [Article Type] Medicine
A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 PandemicMolecular Biosciences Published on 2021-01-252022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] in silico approaches acute respiratory syndrome approach approved drug bioinformatics candidate drug China Chinese clinical clinical symptom confirmed case coronavirus coronavirus disease country CoV COVID-19 death Dexamethasone dosage drug drug target drugs effective effective drug Effectiveness European global public health homology Human human clinical trial Hydroxychloroquine identify in silico Approach library limitation Medicine MERS Middle East MMR molecular molecular docking mump new strain other coronaviruses pandemic pathogenesis of COVID-19 Pathogens Potential recorded registry Remdesivir repurposing researcher respiratory syndrome coronavirus responsible Revisit SARS-CoV-2 Side effects Therapies Trial union Vaccine Vaccines website Wuhan [DOI] 10.3389/fmolb.2020.585899 PMC 바로가기 [Article Type] Molecular Biosciences
Tai Chi for the elderly patients with COVID-19 in recovery period A protocol for systematic review and meta-analysisMeta-Analysis Published on 2021-01-222022-10-04 Journal: Medicine [Category] MERS, 임상, [키워드] approval blood pressure blood vessels Cardiopulmonary caused Chinese clinical Cochrane Library Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient data extraction Effectiveness Elasticity elder patient Elderly patient elderly patients ENhance Ethics evaluate Evidence Health Immunity IMPROVE include information Infrastructure literature Lung function meta-analyses Meta-analysis outbreak Patient positive protocol psychological pressure registry risk of bia Science statistical analysis susceptible systematic review Tai Chi technology virus with COVID-19 [DOI] 10.1097/MD.0000000000024111 PMC 바로가기 [Article Type] Meta-Analysis
Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-AnalysisOncology Published on 2021-01-212022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] 95% CI 95% confidence interval acute respiratory syndrome affected all age groups Analysis analyzed calculated Cancer cancer patient Care caused Chi square test childhood cancer children clinical Cochrane Library Complication conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional eligible England Google Scholar hematological Hematological malignancy heterogeneity Hospitalization Hospitalized intensive care intubation JAMA journal Lancet LILACS measure Medicine medRxiv Meta-analysis Mortality Nature New not different Odds ratio outcomes Oxford pandemic Patient patients with COVID-19 pediatric performed random effect registry Result risk risk factor SARS-CoV-2 Science severe acute respiratory syndrome coronavirus 2 solid tumor solid tumors statistical analysis statistically significant difference stratified suffering survival systematic review Tumor university Ventilation ventilatory support was performed WHO [DOI] 10.3389/fonc.2020.608282 PMC 바로가기 [Article Type] Oncology
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial중증 코로나19 환자에서 이카티반트 및 C1 에스테라제/칼리크레인 억제제의 효능 및 안전성 평가: 3군 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-01-202022-09-10 Journal: Trials [Category] 비임상, 임상, [키워드] accumulation ACE inhibitor ACE inhibitors ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models anti-inflammatory agents antibiotic antithrombotic therapy assigned binding bradykinin breath C1 esterase inhibitor cause Cell clinical clinical trial clinical trials cough COVID-19 Degradation dependent on driving Efficacy and safety eligible patient expressed Icatibant inactivation include Inflammatory inhibitor intravenously invasive ventilation leads lipopolysaccharide LPS lung lung inflammatory response Lungs mechanism mortality rates Non-invasive number Open-label oxygen parallel-group Pneumonia Pneumonitis Prophylactic Protein randomized clinical trial Randomized controlled trial Randomly receive reduce registry renal replacement therapy replacement therapy Respiratory failure SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients Severity of disease Side effect single-center standard care Study protocol subcutaneously supplemental oxygen the cells Universal vasopressor support viral-induced virus [DOI] 10.1186/s13063-021-05027-9 PMC 바로가기 [Article Type] Study Protocol
Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial중등도 또는 중증 COVID-19 환자에 대한 표준 치료와 함께 흡입 황산마그네슘의 효능 및 안전성 평가: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-182022-09-10 Journal: Trials [Category] 임상, [키워드] 1:1 acute severe asthma adjuvant therapy Administered Affect airway smooth muscle alveolar Anti-inflammatory anticipated Arm ARMS arterial blood arterial blood oxygen saturation arterial oxygen saturation arteriole Artery Asthma attack basic Blinding block Block randomisation blocks blood oxygen Blood oxygen saturation bradyarrhythmia calcium calcium antagonist cardiovascular disease cardiovascular diseases Chest computed tomography Chest CT chest CT scan clinical clinical impact clinical manifestation clinical manifestations Clinical studies clinical study clinical trials Combination Computed tomography Computer software Confirmed congestive heart failure Control Controlled trial cough COVID-19 criteria defined diagnosis of SARS-CoV-2 dissemination Dyspnoea Effect Effects Efficacy and safety eight element eligible patient Eligible patients excluded FIVE functional heart block hospital Hospital stay Hospitalized hospitalized patient hospitalized patients Hypoxemia hypoxia impairment IMPROVE improvement inclusion criteria induce Infection inhalation Inhaled Intervention intervention arm intravenous intravenously Length Lung injury lung involvement magnesium sulphate Mask moderate myocardial injury nasopharyngeal secretion National nebulized number objective Open-label outcome oxygen oxygen saturation Parallel Arm parenchyma participant Patient patients with moderate PCR performed polymerase chain polymerase chain reaction protocol pulmonary artery pulmonary involvement randomisation randomised randomised controlled trial randomization Randomly randomly divided RCT receive reduce Registered registration number registry respiratory respiratory airway respiratory airways Respiratory function respiratory tract respiratory tract symptoms Sample size SARS-COV-2 infection saturation severe COVID-19 Shortness of breath shown smooth muscle relaxant standard treatment status Study protocol supplementary material Symptom Tehran therapy Trial Trial registration Ventilation Version website with COVID-19 Yazd [DOI] 10.1186/s13063-021-05032-y PMC 바로가기 [Article Type] Letter
Missing clinical trial data: the evidence gap in primary data for potential COVID-19 drugs누락된 임상 시험 데이터: 잠재적인 COVID-19 약물에 대한 기본 데이터의 증거 격차Research Published on 2021-01-152022-09-10 Journal: Trials [Category] 신약개발, 임상, 치료제, [키워드] adverse events blinded caution checked Clinical findings clinical trial Clinical trial transparency clinical trials ClinicalTrials Concordance conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment disease dosages drug Evidence Favipiravir Google Scholar Hydroxychloroquine Identifier identify in vitro include information lack Lopinavir missing morbidity and mortality pandemic Potential treatment potential treatments regimen registry Repurposed drugs Result Safety information searched Sponsor synthesis Treatment Trial trials [DOI] 10.1186/s13063-021-05024-y PMC 바로가기 [Article Type] Research
The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish HospitalsArticle Published on 2021-01-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019-nCoV 95% CI acute respiratory distress age all-cause mortality analysed Analysis Blood blood cell counts carried Cell Cohort cohort study confounders coronavirus coronavirus 2 Course COVID-19 death decrease described determine eosinophil eosinophils examined hospital hospitalisation hospitalised hospitalised patient ICU admission increase in independent Inhaled internal knowledge lower mortality lymphocyte main outcome measure male Mortality multicentre outcome Patient patients with COVID-19 predictor Prognosis Prognostic value registry required respiratory retrospective SARS-CoV-2 Society Spain Spanish syndrome systemic glucocorticoid value was performed with COVID-19 [DOI] 10.3390/jcm10020305 PMC 바로가기 [Article Type] Article
Sex differences in susceptibility, severity, and outcomes of coronavirus disease 2019: Cross-sectional analysis from a diverse US metropolitan area2019년 코로나바이러스 질병의 감수성, 중증도 및 결과의 성별 차이: 다양한 미국 대도시 지역의 횡단면 분석Research Article Published on 2021-01-132022-08-13 Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, MERS, [키워드] acute renal injury age analyses Analysis appear ARDS biological processe biological processes BMI CCI chain Chain Reaction Charlson Comorbidity Index China Cohort Comorbidity Complication complications conducted coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 severity cross-sectional analysis CURATOR died Diseases electronic medical records EMR Epidemiology Ethnicity Europe Evidence female females healthcare hospital Hospitalized hospitalized COVID-19 patients hospitalized patients hypoxic respiratory failure ICU admission IMPROVE In-hospital in-hospital mortality increasingly independent independent of individual involved likelihood LOS male Male sex males marital status mechanical ventilation median medical records men Mortality Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens observational studies Older outcome outcomes Patient patients PCR Population positive proportion pulmonary reaction Record registry Reporting Respiratory failure risk SARS-CoV-2 positivity SARS-CoV-2 RNA SARS-CoV-2 susceptibility severity Sex difference significantly significantly higher smoking STROBE suggested susceptibility tested Treatment vulnerability with COVID-19 women [DOI] 10.1371/journal.pone.0245556 PMC 바로가기 [Article Type] Research Article