SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021Malawian Blood Donors의 SARS-Cov-2 노출 : 2020 년 1 월과 2021 년 7 월 사이의 혈청 유병률 및 변형 역학 분석Research Article Published on 2021-11-192022-09-01 Journal: BMC Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Beta Beta variant Blood blood donor Blood donors Blood Transfusion Characteristics Community COVID-19 pandemic COVID-19 vaccination cross-protection cross-sectional cross-sectional study D614G database Donor Epidemic epidemic wave epidemic waves First wave Formulation Future Immunity in vitro indication indications less Malawi neutralisation neutralisation activity pandemic Randomly reached Reinfection Result rural areas Sample size SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second wave selected sera seropositive Seropositivity Seroprevalence Study design sub-Saharan Africa subsequent subset supplementary material variant [DOI] 10.1186/s12916-021-02187-y PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021SARS-CoV-2 변이체 및 관련 돌연변이 프로필: 2021년 여름 업데이트Research Article Published on 2021-11-172022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals antigenicity antivirals assist caused circulating variant circulating variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnostic domains Efficacy emerging variants event Evolution full-length Genetic GISAID highlighting Human human-to-human transmission impacts mapped modulate monoclonal antibodies Mutation mutations Nextstrain pandemic profile Protein provide reported respiratory retrieved SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus spike mutation spike mutations Spike protein Stanford summer the SARS-CoV-2 the spike protein Therapeutics three-dimensional structure Vaccine variant variants variants of concern Viral viral infectivity VOCs VOIs website [DOI] 10.1128/Spectrum.01096-21 PMC 바로가기 [Article Type] Research Article
Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2Research Article Published on 2021-11-162022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adaptive mutations Amino acid antibody escape Antibody neutralization characterization characterized clade Cluster conformation coronavirus decrease deletions early stage European Genetic Genotype homoplasy HR2 in vitro information investigated lack Mutation Nasopharyngeal swab neutralization pandemic postfusion predict reduce reduced rigidity SARS-CoV-2 SARS-CoV-2 evolution sequence sera significantly higher Single nucleotide polymorphism spike spike mutation the S protein the spike protein thermal stability transmission cluster vaccinated individual variant variants viral fitness Viral RNA [DOI] 10.1128/mBio.02315-21 PMC 바로가기 [Article Type] Research Article
Efficient Maternofetal Transplacental Transfer of Anti- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Antibodies After Antenatal SARS-CoV-2 BNT162b2 Messenger RNA Vaccination산전 SARS-CoV-2 BNT162b2 메신저 RNA 예방접종 후 항중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 스파이크 항체의 효율적인 모태반 전이Article Published on 2021-11-162022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody concentration binding domain Blood BNT162b2 vaccine collected Cord blood coronavirus coronavirus 2 correlated efficient Immunoglobulin Infant Maternal messenger Neonatal parturient positive Pregnancy respiratory RNA SARS-CoV-2 SARS-CoV-2 BNT162b2 sera serology spike Transplacental vaccination women [DOI] 10.1093/cid/ciab266 PMC 바로가기 [Article Type] Article
SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination seraArticle Published on 2021-11-152022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Administered Beta BNT162b2 BNT162b2 vaccine circulating convalescent coronavirus decrease Delta delta variant dominant Efficacy exhibit exhibited exhibiting immunology Mild neutralization neutralize neutralized Pfizer Prevalence SARS CoV-2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant sensitivity sera spread to Vaccine variant variants Virology wild-type SARS-CoV-2 [DOI] 10.1016/j.isci.2021.103467 PMC 바로가기 [Article Type] Article
Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19COVID-19에 대한 회복기 혈장 요법의 인터페론-α2 자가항체Original Article Published on 2021-11-122022-09-10 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] age Analysis association Auto-antibodies auto-antibody Concentration condition convalescent plasma convalescent plasma treatment COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients determine disease severity Donor Effect ELISA healthy controls Human plasma ICU patient ICU Patients IFN-α2 interferon Interferon alpha longitudinal Longitudinal analyses Neutralization assay neutralized Neutralizing not neutralize Patient performed physiological plasma positive proportion proportions respiratory Respiratory illness respiratory illnesses respiratory tract Result risk SARS-CoV-2 sera serum Sex supplementary material survival tested transfer Viral viral clearance Viral load virological outcome [DOI] 10.1007/s10875-021-01168-3 PMC 바로가기 [Article Type] Original Article
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathologyResource Published on 2021-11-112022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Alter alteration analyzed Cell coronavirus coronavirus disease COVID-19 COVID-19 pathology disease Elevation GM3 implication infected cells Infection inhibitors Level management manifestation mice murine model outcome pathway post infection reflected reversed SARS-CoV-2 SARS-COV-2 infection sera serum significant increase significantly increased sphingolipid sphingolipids sphingosine therapeutic Treatment understanding viral replication [DOI] 10.26508/lsa.202101168 PMC 바로가기 [Article Type] Resource
Update on Intravenous Immunoglobulin in Neurology: Modulating Neuro-autoimmunity, Evolving Factors on Efficacy and Dosing and Challenges on Stopping Chronic IVIg TherapyCurrent Perspectives Published on 2021-11-112022-10-30 Journal: Neurotherapeutics : the journal of the American So [Category] Coronavirus, MERS, SARS, [키워드] Activation addressed affecting Anti-inflammatory effects anti-SARS-CoV-2 antibodies antibody antigenic peptides approved autoantibodies Autoimmune challenge chronic complement conditions conserved cross-react Cytokines Dosing Effect effective Efficacy Encephalitis epilepsy Evidence exhibit Express Factor fatigue FcγRIIb genes encoding Genetic healthy donors Humoral immunity IgG IgG1 Immunomodulation by IVIg Inflammatory mediators infused Initiating and stopping IVIg Intravenous immunoglobulin isotype IVIG IVIg and IgG4 neuro-autoimmunities MMN neurological Neurological disorders neurological sign neuronal pathogenic autoantibody Patient polymorphism positive Protein Randomized controlled trials recent receptors sera stability Stopping Symptom therapy Treatment weakness worsening [DOI] 10.1007/s13311-021-01108-4 PMC 바로가기 [Article Type] Current Perspectives
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화Article Published on 2021-11-102022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type [DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article
High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine RecipientsCOVID-19 mRNA 백신 수용자에서 SARS-CoV-2 스파이크 단백질의 수용체 결합 도메인의 고해상도 선형 에피토프 매핑Research Article Published on 2021-11-102022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-RBD IgG antibodies antibody breadth coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccine demonstrated distribution dominant epitope Establishing High-resolution immune response immune responses Immunity immunoserology in vitro individual infected individuals key factor linear Live virus mapped mapping Microarray Microarrays mRNA mRNA vaccine mRNA vaccines Mutation naïve individuals natural infection neutralization assays neutralization titer Neutralizing antibodies normalized overlapping peptide peptides Pfizer-BioNTech population immunity potency profile Protein provide RBD Receptor binding domain recipient Research Resilience respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants sera serology severe acute respiratory syndrome Coronavirus shown similarities similarity spike Spike protein suggested the RBD the SARS-CoV-2 vaccination Vaccinations Vaccine vaccine-induced antibodies vaccine-induced antibody Vaccine-induced immunity variants of concern Variation variety Viral virus were measured [DOI] 10.1128/Spectrum.00965-21 PMC 바로가기 [Article Type] Research Article