severe cases – Page 37 – Communicable Diseases Research

Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19

Research Article

Published on 2020-07-152022-10-30
Journal: mSphere [Category] COVID-19, SARS,

No Statistically Apparent Difference in Antiviral Effectiveness Observed Among Ribavirin Plus Interferon-Alpha, Lopinavir/Ritonavir Plus Interferon-Alpha, and Ribavirin Plus Lopinavir/Ritonavir Plus Interferon-Alpha in Patients With Mild to Moderate Coronavirus Disease 2019: Results of a Randomized, Open-Labeled Prospective Study

Pharmacology

Published on 2020-07-142022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome adverse event adverse events Analysis Antiviral antiviral therapy Antiviral treatment baseline calculated clinical clinical trial Combination comparable conducted coronavirus coronavirus disease COVID-19 COVID-19 patient difference Effectiveness effectiveness and safety enrolled Follow-up group IFN-α incidence include intention-to-treat interferon-alpha Interferon-α laboratory characteristics Lopinavir/ritonavir median interval Mild Mild to moderate COVID-19 Moderate COVID-19 Mortality negativity no significant difference nucleic acid Observed outcome pandemic Patient patients with SARS-CoV-2 proportion Prospective Prospective clinical trial Randomized regimen Registration Result ribavirin SARS-CoV-2 SARS-CoV-2 nucleic acid severe cases significant increase significantly higher single-center Spread statistically study period the median three groups
[DOI] 10.3389/fphar.2020.01071 PMC 바로가기 [Article Type] Pharmacology

Characteristics of Renal Function in Patients Diagnosed With COVID-19: An Observational Study

Medicine

Published on 2020-07-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Pathological Aspects of COVID-19 as a Conformational Disease and the Use of Pharmacological Chaperones as a Potential Therapeutic Strategy

Pharmacology

Published on 2020-07-102022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome adaptive addition Administered alveolar epithelial cells antiviral therapy Apoptosis artificial ventilation aspect BiP cardiac troponin cell death cell types cellular damage cellular response chaperone conformational coronavirus Coronavirus disease 2019 Coronavirus-2 cough COVID-19 COVID-19 patient creatinine D-dimer damaged deaths dialysis disorder dysfunction Efficacy Endoplasmic reticulum ER stress excessive immune response fatigue Fever glucocorticoid host cell IL-6 increase increase in induce Infection Infectious disease Inflammation initial symptoms interleukin-6 Johns Hopkins University liver enzymes Lymphocytes mechanism membrane multiple organ failure myalgia neuronal cells occur occurred organ support Oxygen therapy Oxygenation pathological pharmacological pharmacological chaperone Pneumonia Potential progressed Protein Proteostasis renal tubular cells Replication reported required SARS-CoV-2 serum severe cases severely ill patients Spread sputum production Strategy survival rate the disease therapy treat unfolded protein response unfolded protein response (UPR) vascular endothelial cells viral infection viral proliferation Wuhan, China
[DOI] 10.3389/fphar.2020.01095 PMC 바로가기 [Article Type] Pharmacology

Adaptive immunity to SARS-CoV-2

Review Article

Published on 2020-07-092022-10-29
Journal: Oxford Open Immunology [Category] COVID-19,

[키워드] absence Activation acute infection acute respiratory syndrome Adaptive immunity antibody Antibody Response Antibody titre blood vessels CD4 CD8 Clinical use common cold coronavirus Correlate of protection Course COVID-19 cross-reactivity Cytokines detectable disease disease severity duration of exposure epitope Evidence expression full recovery functional human coronavirus human coronaviruses Hyperinflammatory IL-6 immune memory immunogenic immunology immunopathological immunopathology individual Infection kidney lung majority mechanism neutralizing antibody neutralizing monoclonal antibody offer Pathogenesis Protective question raised rapid progress response SARS-CoV-2 serum biomarker severe cases susceptibility symptomatic disease Symptoms T cell T-cell T-cell immunity therapeutic target tissue damage Vaccine viral antigens Viral load Virus neutralization while
[DOI] 10.1093/oxfimm/iqaa003 PMC 바로가기 [Article Type] Review Article

Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19

Original Paper

Published on 2020-07-092022-11-01
Journal: Epidemiology and Infection [Category] COVID-19,

Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic: a practical guide for pediatricians

Review

Published on 2020-07-072022-10-31
Journal: Einstein [Category] COVID-19, MERS, SARS,

[키워드] abdominal pain acute respiratory syndrome addressed Adolescent Adolescente adolescents and adult anorexia approach article Betacoronavírus Betacoronavirus bleeding caused Child children chronic liver disease clinical manifestation coronavirus Coronavirus disease 2019 Coronavirus infections/complications COVID-19 COVID-19 pandemic COVID-19 transmission Criança Critical database described determine diarrhea digestive system disease Doenças inflamatórias intestinais Evidence facilitate finding form Gastroenteropatias/etiologia Gastrointestinal Gastrointestinal diseases/etiology gastrointestinal involvement gastrointestinal symptoms General population greater in viral spread include induce Infecções por coronavírus/complicações infecção Inflammatory bowel disease inflammatory bowel diseases intestinal involved Malnutrition manifestation Manifestations MOST nausea nutritional support nutritional therapy occur Pandemia pandemic pediatric Pediatric patient Pediatric patients pelo coronavírus Prevent proportions protocols recommendation reported Research risk of infection SARS-CoV-2 searched severe cases Spread Symptom Terapia nutricional the disease therapy Transmission transmitted Treatment vomiting with COVID-19
[DOI] 10.31744/einstein_journal/2020RW5774 PMC 바로가기 [Article Type] Review

A Proposal for Multidisciplinary Tele-Rehabilitation in the Assessment and Rehabilitation of COVID-19 Survivors

Article

Published on 2020-07-072022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, SARS,

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Article

Published on 2020-07-072022-11-01
Journal: Cell Research [Category] COVID-19, MERS, SARS,

[키워드] 2019 novel coronavirus candidate vaccine cause characterized demonstrated edema evaluate Genome-wide association studies Infection infiltration interstitial pneumonia lung lung; lymphocyte Mild monocyte mortality rate neutralizing antibody non-human primate model Novel coronavirus observation occurred oropharyngeal swab oropharyngeal swabs outbreak platform Pneumonia post infection Primary infection PROTECT provide public health reflected Replication respiratory tract respiratory tract tissues rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RNA severe cases susceptible viral infection Viral RNA virus Whole genome amplification World Health Organization
[DOI] 10.1038/s41422-020-0364-z PMC 바로가기 [Article Type] Article

Cancer Patients Have a Higher Risk Regarding COVID-19–and Vice Versa?

Opinion

Published on 2020-07-062022-10-28
Journal: Pharmaceuticals [Category] COVID-19,