therapeutic target – Page 37 – Communicable Diseases Research

Investigating the human protein-host protein interactome of SARS-CoV-2 infection in the small intestine

Original Article

Published on 2020-01-012022-10-31
Journal: Gastroenterology and Hepatology From Bed to Bench
[Category] COVID-19,

Introducing APOA1 as a key protein in COVID-19 infection: a bioinformatics approach

Original Article

Published on 2020-01-012022-10-31
Journal: Gastroenterology and Hepatology From Bed to Bench
[Category] COVID-19,

[키워드] adverse effect Analysis apoA1 app applied approach approach approved assigned bioinformatics biological process biological processe Biomarker Biomarkers candidate central nodes complementary complex contribute coronavirus disease COVID-19 COVID-19 patient Cytoscape software database demonstrated diagnostic down-regulation dysregulated dysregulation EGF expressed healthy hidden Interaction introduced molecular nervous system nine Patient PPI Protein protein complex protein complex protein complexes protein interaction mapping protein-protein interaction proteomics severity of COVID-19 the disease therapeutic therapeutic target Urine urine proteome was used were used
PMC 바로가기 [Article Type] Original Article

Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies

새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다

Research Article

Published on 2019-08-072022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms
[DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

C형 간염 바이러스는 직접 작용하는 항바이러스제에 의한 감염 치료 후 후성 유전적 특징을 남깁니다.

Research Article

Published on 2019-06-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acting Alter alteration Anti-HCV Antiviral approach Biomarker Cell cells change changes in characterized Chemotherapy ChIP-seq chromatin chromatin immunoprecipitation chronic hepatitis develop direct-acting antiviral disease drug Effect EGFR EGFR Inhibitor enzyme Epidemiological study Epigenetic Erlotinib Europe expected explain expression followed by gene signature Genome HCC HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma histone Hit and run host gene expression identify in vitro induce infected case infected patient Infection inhibit inhibitor interferon life cycle liver Liver Biopsy marker mechanism Modification molecular mechanism Mortality Multiple Multiple epidemiological studies Next-generation sequencing observation offer oncogenic outcome Pathogenesis pathogenic Pathways Patient persist poor prognosis post-translational modification predominant Prevalence proceed replaced repressed risk risk factor RNA signaling pathway specific inhibitor specific inhibitors sustained the cells therapeutic target therapy Treatment Tumor unmet need Viral protein Viral proteins virological response virus while
[DOI] 10.1371/journal.pgen.1008181 PMC 바로가기 [Article Type] Research Article

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination

Immunology

Published on 2019-05-092022-11-01
Journal: Frontiers in Immunology
[Category] Coronavirus, MERS,

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease

쌍을 이루는 면역글로불린 유사 유형 2 수용체 알파 G78R 변이체는 리간드 결합을 변경하고 알츠하이머병에 대한 보호를 부여합니다

Research Article

Published on 2018-11-022022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 7q21 locus Alpha Alter Alzheimer’s disease association binding Biology causal allele Cell cell types complement component complement component 4A complex interaction disease Donor entry receptor exogenous ligand exogenous ligands expressed G78 G78R genetic component genetic risk factors glycoprotein B herpes simplex herpes simplex virus highlight homozygous HSV-1 HSV-1 recurrence immune individual Infection inhibitory inhibitory receptor innate immune cell Interaction Ligand locus Macrophage macrophages microglia microglial missense variant neurodegenerative disorder neutrophil Neutrophils O -glycosylated protein O -glycosylated proteins Paired Immunoglobulin-like Type 2 Receptor Alpha PILRA PILRA G78R PILRA ligand PILRA ligands PROTECT Protective R78 recognize recurrence reduce reduced residue residues resulting risk rs1476679 rs1859788 sialic acid Signaling significantly therapeutic target Type variant virus
[DOI] 10.1371/journal.pgen.1007427 PMC 바로가기 [Article Type] Research Article

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크

Research Article

Published on 2017-09-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes
[DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin
[DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Research Article

Published on 2013-07-252022-10-28
Journal: PLoS ONE
[Category] Coronavirus,