Emerging virus diseases: can we ever expect the unexpected?Review Published on 2012-12-262023-08-30 Journal: Emerging Microbes & Infections [Category] E형 간염, [키워드] arenaviruses emerging infections filoviruses Hantaviruses receptors virus replication zoonoses [DOI] 10.1038/emi.2012.47 PMC 바로가기 [Article Type] Review
In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 geneResearch Published on 2012-08-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Apoptosis approach assays Cell cell proliferation characterized contagious Coronavirus replication Cytopathic effect demonstrated diarrhea effective Efficiency Evidence examined expressing expression expression plasmid expression plasmids gastroenteritis Genome high mortality in vitro indicated Infection inhibit inhibited inhibitory effect N gene ORF ORF 7 Quantitative Replication reporter Result RNA RNA interference RT-PCR analysis selected sequence short hairpin RNA shown significantly specificity STABLE target gene TCID TGEV the vaccine therapeutic transmissible gastroenteritis virus Treatment viral disease viral infections viral replication virus virus replication virus titer vomiting [DOI] 10.1186/1743-422X-9-176 PMC 바로가기 [Article Type] Research
Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirusResearch Published on 2012-05-182023-08-30 Journal: Journal of Neuroinflammation [Category] E형 간염, [키워드] astrocytes blood–brain barrier BMVECs Cytokines cytomegalovirus Neuroinflammation pericytes virus replication [DOI] 10.1186/1742-2094-9-95 PMC 바로가기 [Article Type] Research
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoVResearch Article Published on 2011-12-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast [DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus InhibitorsResearch Article Published on 2011-10-272022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation acute respiratory syndrome anti-infective drug Antiviral antiviral target approach Author automated Bacteria binding blocked common cold viruses CoV CoV-229E CoVs cyclophilin cyclosporin A Cytokine dysregulation demonstrated derivative different drug element Epidemics Factor FKBP1A FKBP1B fungi Host host cell host protein Human identification identify Immune cell include induce Infection Infectious Bronchitis Virus inhibited inhibitor Interaction interaction partner interleukin 2 involved led to maintain metabolism modulate Neurological disease non-structural protein nsp1 organism outbreak overlap parasites pathogen Pathogenesis pathway PPIA PPIB PPIG PPIH Protein Replication SARS-CoV severe SARS suggested Systems biology target targets tested Vaccine Viral protein virus virus replication Virus-host interaction viruses [DOI] 10.1371/journal.ppat.1002331 PMC 바로가기 [Article Type] Research Article
Quercetin 7-rhamnoside reduces porcine epidemic diarrhea virus replication via independent pathway of viral induced reactive oxygen speciesResearch Published on 2011-10-042022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] addition antioxidant antiviral activity Course CPE Cytopathic effect DNA fragment DNA fragmentation Effect epidemic diarrhea flow cytometry Hypothesis inactive independent induce Infection investigated NAC pathway PEDV Production quercetin reactive oxygen specy reduce reduced reduction Result ROS Vero Cell virus replication [DOI] 10.1186/1743-422X-8-460 PMC 바로가기 [Article Type] Research
Bat Coronaviruses and Experimental Infection of Bats, the PhilippinesResearch Published on 2010-08-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Administered After Analysis bat bat coronavirus bats Clinical sign coronavirus CoV CoVs Cynopterus detect Experimental infection found fruit genus Alphacoronavirus genus Betacoronavirus group identity Infected Infection intestine investigated Laboratory Pathogenesis Prevalence Research RNA RNA-dependent RNA polymerase Rousettus SARS sequence sequence identity Severe acute respiratory syndrome tested the Philippines virus virus replication virus RNA viruses zoonoses [DOI] 10.3201/eid1608.100208 PMC 바로가기 [Article Type] Research
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human PrimatesResearch Article Published on 2010-02-052022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome advanced age age analyses Analysis anti-inflammatory action ARDS Author cause Comprehensive contributed coronavirus correlated develop different differential expression diminishe disease displaying exacerbated expression Gene genomic H5N1 host response IFN-β IL-8 in viral increase in individual individuals Infection Inflammation influenza A Innate Intervention life-threatening Lungs macaque macaques Microarray modulation molecular mRNA level NF-κB outcome pandemic pathogen Pathogenesis pathology Pathways Patient primate pro-inflammatory gene expression Protective provide reduce reduced Replication response reveal SARS-CoV SARS-CoV infection severe severe pathology severity shown significantly significantly more syndrome Treatment type I Type I IFN type I interferon viral infection viral replication viral respiratory virus infection virus replication without affecting [DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivoResearch Published on 2009-08-242022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA [DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research