Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico InvestigationArticle Published on 2020-05-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Antiviral antiviral agent Antiviral agents binding domain carried component Corona virus coronavirus COVID-19 COVID-19 symptoms docking docking score enzyme Essential essential oil essential oils hACE2 investigation Ligand M pro molecular docking molecular docking analysis normalized Oil pathogenic viruses Potential Protein Protein target RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 RdRp shown Spike protein target targets the SARS-CoV-2 unlikely virus [DOI] 10.3390/ijms21103426 PMC 바로가기 [Article Type] Article
Tocilizumab for the treatment of severe coronavirus disease 2019Research Article Published on 2020-05-102022-10-04 Journal: Journal of medical virology [Category] 진단, 치료제, [키워드] adverse event Antiviral agents cardiovascular disease Chronic kidney disease contribute coronavirus cough COVID‐19 COVID‐19 declined Diabetes Mellitus died discharged Dyspnea IL‐6 immune response improve clinical outcomes Inflammatory inflammatory markers inhibitor intensive care interquartile range invasive ventilation limitations majority male manifestation median median age oral temperature Pathogenesis Patient presenting symptoms proportion radiological improvement Randomized controlled trials reduced retrospective SARS‐CoV‐2 severe coronavirus disease Support Tocilizumab tocilizumab therapy Treatment Ventilation ventilatory support [DOI] 10.1002/jmv.25964 PMC 바로가기 [Article Type] Research Article
A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirusShort Communication Published on 2020-05-082022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] added anionic Antiviral antiviral activity Antiviral agents antivirals cationic cause cell cultures Consequences coronavirus CoV decrease dendrimer effective group IMPROVE Infection intrinsic investigated MERS Middle East outcome pilot study research and analysis methods respiratory syndrome coronavirus sodium Vero cells viral disease virus virus classification were used [DOI] 10.1002/jmv.25928 PMC 바로가기 [Article Type] Short Communication
SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary InflammationArticle Published on 2020-04-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated Analysis Antiviral agents binding activity CCL5 chemokine coronavirus CXCL10 demonstrated Diffuse alveolar damage domain epithelial cell examined expression G-quadruplex human lung in vitro indicated infiltration Inflammatory response inhibitor initiate Lung injury lung tissue macrodomain Macrophage mice modulated Monocytes NLRP3 NLRP3 inflammasome plasmids potential therapeutic target protein 3 pulmonary pulmonary inflammation respiratory SARS pathogenesis SARS-coronavirus SARS-CoV SARS-CoV unique domain (SUD), CXCL10 significantly Symptoms triggered unique up-regulated wild type [DOI] 10.3390/ijms21093179 PMC 바로가기 [Article Type] Article
Natural product-derived phytochemicals as potential agents against coronaviruses: A reviewArticle Published on 2020-04-302022-11-01 Journal: Virus research [Category] COVID-19, SARS, [키워드] Abstract acute respiratory syndrome Animal coronaviruses antiviral activity antiviral agent Antiviral agents article caffeic acid Compound compounds Coronaviral Coronaviridae coronavirus coronavirus inhibitor coronavirus strains COVID-19 database disease effective fused Human IBV include infections Infectious Bronchitis Virus lack majority MERS Middle East Middle East respiratory syndrome (MERS) Mortality MOST natural Naturally Other plants plasma concentrations polar quercetin Research responsible SARS-CoV-2 searched Severe acute respiratory syndrome (SARS) small molecule syndrome therapeutic therapeutic agent Traditional medicine utility [DOI] 10.1016/j.virusres.2020.197989 PMC 바로가기 [Article Type] Article
Effectiveness of convalescent plasma therapy in severe COVID-19 patients중증 코로나19 환자에서 회복기 혈장 요법의 효과530 Published on 2020-04-282022-09-06 Journal: Proceedings of the National Academy of Sciences of [Category] Communicable Disease, COVID-19, SARS, [키워드] Absorption addition Antibody titers antiviral agent Antiviral agents approved C-reactive protein clinical benefit Clinical outcome clinical outcomes clinical symptom Clinical symptoms convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 criteria disappearance Donor dose Endpoint enrolled feasibility FIVE global health Health IMPROVE laboratory parameter Laboratory parameters lung lesion lung lesions lymphocyte Lymphocyte count maintain median time Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Novel coronavirus novel coronavirus disease optimal dose oxyhemoglobin oxyhemoglobin saturation parameter Patient pilot project primary endpoint Radiological examinations randomized trial Seven severe adverse effect severe COVID-19 severe COVID-19 patient Severe patient severe patients Significance significantly supportive care the patient therapy transfused transfusion Treatment Treatment outcome trials undetectable Viral Viral load Viral RNA Viremia [DOI] 10.1073/pnas.2004168117 PMC 바로가기 [Article Type] 530
Hyperglycemia, hydroxychloroquine, and the COVID‐19 pandemicReview Published on 2020-04-272022-10-30 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] abrogate ACE2 acute respiratory distress agent antibody‐mediated cell‐mediated cytotoxicity Antiviral agents appear ARDS blunt Concentration Course COVID‐19 diabetes Diabetes Mellitus disease enzyme explained glycosylated glycosylation Hydroxychloroquine hyperglycemia Inflammatory response interfere lung epithelium Macrophage macrophage polarization mechanism neutralizing antibody overactive pandemic Pathogenesis Protein pulmonary immune response receptor SARS Coronavirus SARS‐CoV‐2 severity Spike protein susceptible patients symptom onset syndrome the disease Viral load viral particle [DOI] 10.1002/jmv.25887 PMC 바로가기 [Article Type] Review
Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for CoronavirusesReview Published on 2020-04-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Antiviral agents antiviral drug candidate Clinical use Compound coronavirus Coronaviruses drug Drug discovery drug resistance drugs fungal fungal metabolites fungi HIV-1 immunomodulatory activity Immunomodulatory agents inhibitory natural natural products offer Potential potential therapeutic agent protease Protease activity Protease inhibitor protease inhibitors Side effect therapeutic potential Treatment viral disease [DOI] 10.3390/molecules25081800 PMC 바로가기 [Article Type] Review
Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning modelCommunications Published on 2020-03-302022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] addition antiretroviral Antiviral agents antiviral drug Atazanavir China complex component coronavirus COVID-19 deep learning drug Drug repurposing drug-target effective HIV Human immunodeficiency virus identify incidence rate Infection inhibit SARS-CoV-2 inhibitory potency Interaction Kaletra lack medication molecule MT-DTI Novel coronavirus predicted Prevent proteinase Remdesivir Replication Ritonavir SARS-CoV-2 target tested the SARS-CoV-2 treat Treatment treatment strategy Viral protein was used Wuhan [DOI] 10.1016/j.csbj.2020.03.025 PMC 바로가기 [Article Type] Communications
Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory VirusesArticle Published on 2020-03-252022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] (thio)semicarbazone-based benzimidazoles acute respiratory illness agent anti-coronavirus activity anti-influenza activity anti-RSV activity antiviral activity antiviral agent Antiviral agents binding Biological caused Combination Compound compounds Contact coronavirus derivative effective explained Human human respiratory viruses hydrazone-based benzimidazoles improvement influenza A virus inhibit inhibitor medical need Modification molecular docking analysis molecular modelling studies novel pathology Protein reported respiratory respiratory syncytial virus responsible ribavirin RNA virus RSV SAR subsequent synthesis these compound Treatment variety viruses [DOI] 10.3390/molecules25071487 PMC 바로가기 [Article Type] Article