Autoimmune – Page 38 – Communicable Diseases Research

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

COVID-19에 대한 타고난 면역 반응을 개선하기 위해 브라질에서 의료 종사자의 BCG 재접종: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-262022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] accompany activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Antibiotics antiviral immune response approved assigned Autoimmune Autoimmune diseases Bacillus BCG BCG revaccination BCG vaccination bcg vaccine blinded Blinding block blocks both groups Brazil Breastfeeding carried CFU Characteristics Chemotherapy childhood city clinical trial Committee Comorbidities Comorbidity confirmation Contact contact with control group Coronavirus-2 COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptoms COVID-19 test cross-protection determined by diagnosed direct contact disease disease severity Diseases dissemination dose doses Effectiveness element elicited eligibility criteria Fever health worker health workers healthcare providers HIV hospital Hypothesis ICU identification number IgG and IgM IgM and IgG IgM test immunosuppressive IMPROVE in both group incidence incidence of COVID-19 Inclusion inclusion criteria India induce Infection infections information innate immune response investigator Laboratory lateral flow less macrophages medication meet memory monocyte Monocytes Mortality naso-oropharyngeal swab neutrophil Neutrophils NK NK cell number Nurses objective Open-label outcome outcomes pandemic parallel-group participant physiotherapists platform presenting Prevent Primary outcome Primary outcomes professional protocol randomisation randomised randomised controlled trial randomization Randomized receive recruit recruitment reduce Registered registration number researcher researchers respiratory revaccination right arm RT-PCR Sample size SARS-CoV-2 scar sealed Secondary objective Secondary objectives secondary outcome severe acute respiratory syndrome Coronavirus severity solid tumour specimen statistical analyses status steroid Study protocol Symptom symptomatic infection the disease the vaccine Trial Trial registration Tuberculosis two groups vaccination Vaccine virus virus infection virus infections was performed website WHO
[DOI] 10.1186/s13063-020-04822-0 PMC 바로가기 [Article Type] Letter

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

생명을 위협하는 COVID-19 환자에서 I형 IFN에 대한 자가항체

Research Article

Published on 2020-10-232022-08-13
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Affect affected age antiviral immunity Asymptomatic auto-Ab auto-Abs autoantibodies autoantibody autoantibody system Autoimmune Autoimmunity B cell Beck binding can not candidate gene approach cause causes Clinical course clinical phenotype clinical phenotypes clinical variability collected complex component components Concentration conditions coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen death determine disease Diseases downstream enrichment enrolment epidemiological excess explain Genes genetics genomics study had milder phenotype healthy control healthy individual healthy individuals highest Human Hypothesis identify IFN IFN response IFN-stimulated genes IFN-α IFN-α/β IFN-α2 IFN-β IFN-γ IFNAR IFNs IgG IL-17A IL-6 immune system Immunity Immunoglobulin Immunoglobulin G immunological impair impairing in healthy individuals in vitro Inborn errors increase in individual infected with SARS-CoV-2 Infection Infectious diseases interferon interferon regulatory factor interferon-γ interferons interferons (IFNs) interleukin interleukin-6 intrinsic involved IRF ISGs lack life-threatening life-threatening coronavirus disease likelihood male mechanism men mild SARS-CoV-2 infection morbidity morbidity and mortality mucocutaneous candidiasis Mutation mycobacterial disease neutralize Neutralizing outcomes pandemic pathogen pathogen-induced inflammation pathway Patient patients patients hospitalized Perspective phosphorylated Plasmapheresis Pneumonia Prevent pSTAT receptor receptors Regulation respiratory rising risk risk factor SARS-CoV-2 SARS-COV-2 infection Science searched serum IFN-α level severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia shown silent infection staphylococcal susceptible tested the patient this system TLR Toll-like receptor Transcription Treatment trials type 1 interferon type 1 interferons type I Type I IFN type I IFNs underlie undetectable Vaccine Viral viral infections viral respiratory diseases while women
[DOI] 10.1126/science.abd4585 PMC 바로가기 [Article Type] Research Article

Antibodies against immunogenic epitopes with high sequence identity to SARS-CoV-2 in patients with autoimmune dermatomyositis

Letter

Published on 2020-10-222022-10-28
Journal: Annals of the rheumatic diseases [Category] COVID-19, Fulltext, SARS,

[키워드] autoantibodies Autoimmune Autoimmune diseases dermatomyositis epitope immunogenic Patient SARS-CoV-2 sequence identity
[DOI] 10.1136/annrheumdis-2020-217522 PMC 바로가기 [Article Type] Letter

Kinase inhibition in autoimmunity and inflammation

Reviews

Published on 2020-10-192022-10-05
Journal: Nature Reviews Drug Discovery [Category] 바이오마커, 치료제,

[키워드] alleviate Autoimmune Autoimmunity BTK clinically dysregulated Effect Efficacy Inflammation Inflammatory diseases Inflammatory mediators inflammatory pathways inhibitor irak4 kinase Kinase inhibitor medical need offer regulate review SYK Therapeutic approach tissue Treatment
[DOI] 10.1038/s41573-020-0082-8 [Article Type] Reviews

Intravenous immunoglobulin immunotherapy for coronavirus disease‐19 (COVID‐19)

News & Commentary

Published on 2020-10-162022-10-31
Journal: Clinical & Translational Immunology [Category] COVID-19,

[키워드] Autoimmune benefit case sery coronavirus COVID‐19 COVID‐19 patients Critically ill healthy donor IgG Immunoglobulin Immunotherapy Inflammatory diseases management open‐label Placebo‐controlled randomised clinical trial randomised controlled trial retrospective Treatment
[DOI] 10.1002/cti2.1198 PMC 바로가기 [Article Type] News & Commentary

Association between autoimmune diseases and COVID-19 as assessed in both a test-negative case–control and population case–control design

Original Research

Published on 2020-10-062022-10-27
Journal: Autoimmunity Highlights [Category] COVID-19,

[키워드] Analysis association Autoimmune Autoimmune disease Autoimmune diseases Characteristics Cohort correlated COVID-19 COVID-19 case COVID-19 epidemic defined disease Evidence Hashimoto’s disease hemolytic anemia higher risk increased risk infodemic information initial knowledge outbreak performed positive protection psoriatic arthritis recommendation replicate respiratory infection Result rheumatoid arthritis risk factor SARS-CoV-2 SARS-COV-2 infection spondylitis Spread statistically significant subject subjects Symptoms systemic lupus erythematosus Systemic sclerosis test-negative design tested web-based platform worse prognosis
[DOI] 10.1186/s13317-020-00141-1 PMC 바로가기 [Article Type] Original Research

Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report

Case Report

Published on 2020-10-052022-10-30
Journal: Medicina [Category] COVID-19, MERS, SARS,

O06 Inflammatory arthritis triggered by COVID-19

Oral Abstract Presentations (Tuesday 13 October 2020)

Published on 2020-10-032022-10-28
Journal: Rheumatology Advances in Practice [Category] COVID-19,

[키워드] ankle joints Anosmia Arthritis Autoimmune Autoimmune disease breathlessness caused CCP co-morbidity commenced Complication concern conditions consequence consolidation cough COVID-19 CRP CXR Diagnosis diffuse disease ENA ESR fatigue feature Fever flu-like symptom GGO Hilar illnesses immune Immunocompromised patients individual induce Infection Infectious disease Inflammatory arthritis inflammatory disease initial initial symptoms investigated investigation joint knee joint knowledge lethargy Lymphadenopathy male medication multifocal Musculoskeletal myalgia negative normal occur overlapping Pain pandemic of COVID-19 patchy pathogen pathogenic mechanism Patient patients with COVID-19 positive Prednisolone Prognosis reported respiratory rheumatic disease risk of COVID-19 SARS-CoV-2 SARS-CoV-2 PCR Significant sore throat suggested Swab systemic the disease therapy treat triggered triggering factor viral infection widespread β-coronavirus
[DOI] 10.1093/rap/rkaa053.005 PMC 바로가기 [Article Type] Oral Abstract Presentations (Tuesday 13 October 2020)

Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)

Immunology

Published on 2020-10-022022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation acute exacerbation acute respiratory distress Analysis ARDS autoantibodies autoantibody Autoimmune Autoimmunity clinical Clinical course collagen Computed tomography connective tissue connective tissue disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detection determine died disease ENA enrolled exacerbating Exacerbation feature fibroblast FIVE heterogeneous High-resolution histopathological finding Histopathology immunoblot immunofluorescence intensive care treatment Interstitial lung disease interstitial thickening investigated Laboratory testing mechanism objective Occurrence overlapping pathophysiology Patient Pneumonia positive predict Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection serological severe complication severe COVID-19 significantly similarity syndrome the disease Therapeutic strategies tissue sample understanding was performed
[DOI] 10.3389/fimmu.2020.587517 PMC 바로가기 [Article Type] Immunology