Clinical and inflammatory features based machine learning model for fatal risk prediction of hospitalized COVID-19 patients: results from a retrospective cohort studyResearch Article Published on 2021-01-072022-10-28 Journal: Annals of Medicine [Category] COVID-19, SARS, [키워드] Accuracy age AUC branch build city clinical conducted COVID-19 COVID-19 cases COVID-19 mortality COVID-19 patients death disease severity effective evaluated external validation extreme Extreme gradient boosting fatal risk feature Features ferritin French help High-sensitivity C-reactive protein hospital hospitalized COVID-19 identify IL-10 Inflammatory laboratory feature lactate dehydrogenase LDH machine learning New objective performance Precision predict predictor Randomly Result retrospective cohort study risk Risk factors risk of COVID-19 screened selected sensitivity Serum level severity the disease Valley was used Wuhan [DOI] 10.1080/07853890.2020.1868564 PMC 바로가기 [Article Type] Research Article
Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics SimulationsChemistry Published on 2021-01-052022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 Alanine Area binding build cause confirmed case coronavirus disease COVID-19 crystal structure death develop drug Dynamics enzyme facilitate FIVE full-length spike protein homology homology modeling host cell host cell receptor host cells human ACE2 in silico in viral Infection interacting residue Interaction Mechanics membrane fusion modeling Molecular dynamics simulation molecular dynamics simulations monomer Mutant SARS-CoV-2 outer membrane Prevent Protein RBD Receptor binding domain receptor protein reported residue respiratory responsible SARS-CoV-2 SARS-COV-2 infection Simulation spike Spike protein ssRNA surface the SARS-CoV-2 the spike protein treat triggering trimer trimeric Trimeric spike protein understanding Vaccine virion was used wild-type SARS-CoV-2 [DOI] 10.3389/fchem.2020.622632 PMC 바로가기 [Article Type] Chemistry
White paper on challenges and opportunities for TB elimination with focus on COVID & Post-COVID era developed through scientific roundtable resolutions at NATCON 2020NATCON 2020에서 과학적 원탁회의 결의를 통해 개발된 COVID 및 Post-COVID 시대에 초점을 맞춘 결핵 퇴치를 위한 도전과 기회에 대한 백서Article Published on 2021-01-012022-09-11 Journal: The Indian journal of tuberculosis [Category] 치료기술, [키워드] build categories category challenges Conference country COVID Elimination epidemiological epidemiologist epidemiologists Government highlight India meeting monitoring Opportunities platform pool Post-COVID recommendation Scientific community starting point TB. Topic White paper [DOI] 10.1016/j.ijtb.2021.01.002 PMC 바로가기 [Article Type] Article
Chinese Medicine in Fighting against Covid-19: Role and InspirationCovid-19와 싸우는 한의학: 역할과 영감Article Published on 2021-01-012022-08-31 Journal: Chinese journal of integrative medicine [Category] 변종, 신약개발, 치료제, [키워드] Artemisinin build caused Chinese Chinese medicine coronavirus COVID-19 current death demonstrated develop diagnosing driving drug drug candidate drug candidates Effect effective effective drug effective drugs Evidence Fighting herbal medicine Infection Innovation inspiration killing lead medical system Medicine mutant pandemic pathogen patients researcher resource role SARS-CoV-2 theory treasure Treatment Vaccine Vaccines virus [DOI] 10.1007/s11655-020-2860-x PMC 바로가기 [Article Type] Article
Re-Thinking the Role of Government Information Intervention in the COVID-19 Pandemic: An Agent-Based Modeling AnalysisArticle Published on 2020-12-282022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Accuracy aggravate build COVID-19 COVID-19 pandemic diffusion dissemination Effectiveness Factor Government Infectious disease information information blocking information disclosing information intervention Intervention modeling opposite outbreak preference public health reducing risk of infection role social network virus [DOI] 10.3390/ijerph18010147 PMC 바로가기 [Article Type] Article
Interactive Molecular Dynamics in Virtual Reality Is an Effective Tool for Flexible Substrate and Inhibitor Docking to the SARS-CoV-2 Main Protease가상 현실의 대화형 분자 역학은 SARS-CoV-2 메인 프로테아제에 대한 유연한 기질 및 억제제 도킹을 위한 효과적인 도구입니다Article Published on 2020-12-282022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종, 신약개발, 치료제, [키워드] approach backbone binding interactions build Community complexes COVID-19 creating crystal structure crystal structures crystallographic structure demonstrated docked docking Drug development Dynamics effective effort enzyme flexibility flexible focus hydrogen hydrogen bonds inhibitor MD simulation MD simulations Metrics molecular molecular dynamics MPro oligopeptide open physically PLOS protease Protein protein complex protein complexes Protein target protocol provide REALITY recommendation Research RMSD SARS-CoV-2 virus small molecule small molecule drug small molecule drugs software framework Structure structures substrate targets tested the SARS-CoV-2 the SARS-CoV-2 virus user Viral virtual reality [DOI] 10.1021/acs.jcim.0c01030 PMC 바로가기 [Article Type] Article
COVIDNet-CT: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases From Chest CT ImagesMedicine Published on 2020-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] abnormality approach build Care caused center characteristic Chest CT image China Clinicians collected complement Complication Computed tomography conditions coronavirus disease COVID-19 COVID-19 case COVID-19 infection CT scan dataset deep deep learning detection disease effective Healthcare system identify Image image classification infected with COVID-19 lung negative RT-PCR network Neural Non-COVID-19 pandemic Patient Pneumonia reliability reported researchers RT-PCR testing SARS-CoV-2 screening method undergo while worsening respiratory status [DOI] 10.3389/fmed.2020.608525 PMC 바로가기 [Article Type] Medicine
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI modelsResearch Published on 2020-12-232022-11-01 Journal: Genome Biology [Category] COVID-19, SARS, [키워드] adaptive adaptive mutation Algorithm Analysis build change contrary coronavirus COVID-19 COVID-19 pandemic dispersal drug expression Frequency functional Haplotype Helicase High-resolution Host hotspot identify implication information Local adaptation molecular molecular evolution Mutagenesis Mutation nsp13 Pandemics Positive selection Pro rapid expansion reduced Result RNA-dependent RNA polymerase robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation sequence spatiotemporal spike glycoprotein Spread subsequent Surveillance These data tissue Transmission USA virus [DOI] 10.1186/s13059-020-02191-0 PMC 바로가기 [Article Type] Research
Health research system resilience: lesson learned from the COVID-19 crisisCommentary Published on 2020-12-182022-10-31 Journal: Health Research Policy and Systems [Category] Coronavirus, MERS, SARS, [키워드] accounted analyzed build category collected component conditions Consequences Coronavirus infections/prevention and control COVID-19 COVID-19 crisis COVID-19 pandemic Epidemic Epidemics Evidence feasible Health Health policy knowledge National Pandemics/prevention and control policy making Prevent recognize required Research Research question Resilience respond responsible Shock timelines translational medical research was used while [DOI] 10.1186/s12961-020-00667-w PMC 바로가기 [Article Type] Commentary
Staying Connected: Reaching Out to Psychiatric Patients During the Covid-19 Lockdown Using an Online BlogPublic Health Published on 2020-12-172022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] Blog build citizen involvement clinical psychiatry connection contribute Corona virus coronavirus COVID-19 District E-health effort experienced involvement future work information lockdown loneliness management Measures medical condition outpatient clinic pandemic Patient patients Psychiatric psychiatry Regensburg required risk SARS-CoV-2 social isolation Treatment virus [DOI] 10.3389/fpubh.2020.592618 PMC 바로가기 [Article Type] Public Health