c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio choleraec-di-GMP는 Vibrio cholerae에서 TfoY의 LonA 의존성 단백질 분해를 억제합니다Research Article Published on 2020-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Analysis Bacterial Bacterial pathogens bacterial species binding biochemical biochemical analysis Cell cell division cellular processe cellular processes cholerae condition connection consequence conserved Control country Critical diarrheal diarrheal disease disease cholera Endemic expression flagellar globe help Host identify inhibit Intervention killing life cycles list mechanism molecular motility organism Pathogens protease Protease activity Protein protein stability proteome proteomes provide receptor regulate regulated required secretion Signaling significantly strain substrate substrates translational Vibrio cholerae virulence virulence gene wild-type [DOI] 10.1371/journal.pgen.1008897 PMC 바로가기 [Article Type] Research Article
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune ResponseImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] adaptive Against Analysis Anti-viral CD8+ CD8+: T lymphocyte subsets connection conserved COVID COVID-19 CTL cytolytic drug ENhance function GSK-3 Hypothesis immune response information inhibit inhibition inhibitor knowledge limit mice N protein natural killer NK cell pandemic Phosphorylation protein sequences question reducing reduction in Replication residue response responses SAR SARS-CoV2 SARS-CoV2 infection Serine small molecule inhibitor T-cell T-Cells (or lymphocytes) the N protein Therapeutic approach therapeutic approaches therapy Vaccine viral (or virus) viral infection viral replication virus while [DOI] 10.3389/fimmu.2020.01638 PMC 바로가기 [Article Type] Immunology
Building a PubMed knowledge graphData Descriptor Published on 2020-06-262022-10-04 Journal: Scientific Data [Category] 신약개발, [키워드] Abstract articles authors building classification Communication and replication computational modeling connection Data integration Data mining Deep Learning Method domain entity funding source information knowledge Metadata NIH ORCID organization PubMed abstracts reported resource significantly technology transfer [DOI] 10.1038/s41597-020-0543-2 PMC 바로가기 [Article Type] Data Descriptor
Leveraging User Experience to Improve Video Consultations in a Cardiology Practice During the COVID-19 Pandemic: Initial InsightsViewpoint Published on 2020-06-252022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] assistant Attention build Cardiology Care clinics conducted connection consultation coronavirus disease COVID-19 COVID-19 pandemic Design thinking disease experience Features Health hospital implementation IMPROVE information insight interview pandemic Patient Practice Rapid risk Telemedicine the patient user user experience [DOI] 10.2196/19771 PMC 바로가기 [Article Type] Viewpoint
COVID-19 health worries and anxiety symptoms among older adults: the moderating role of ageismBrief Report Published on 2020-06-172022-10-29 Journal: International Psychogeriatrics [Category] COVID-19, SARS, [키워드] Adults age ageism Anxiety anxiety symptom anxiety symptoms collected connection consequence coronavirus disease COVID-19 COVID-19-related health worries demonstrated examined Health highlight loneliness Older pandemic physical Psychological outcomes social isolation Symptom [DOI] 10.1017/S1041610220001258 PMC 바로가기 [Article Type] Brief Report
A case of COVID-19 in a patient with a univentricular heart post total cavopulmonary connection (Fontan) surgeryBrief Report Published on 2020-06-162022-10-31 Journal: Cardiology in the Young [Category] COVID-19, SARS, [키워드] affected caused cavopulmonary CHD circulation connection Coronavirus disease 2019 COVID COVID-19 Fontan global pandemic health condition Healthcare system Patient univentricular circulation [DOI] 10.1017/S1047951120001882 PMC 바로가기 [Article Type] Brief Report
15 Smartphone Apps for Older Adults to Use While in Isolation During the COVID-19 PandemicEndemic Infections Published on 2020-05-142022-10-28 Journal: Western Journal of Emergency Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome cognitive connection coronavirus coronavirus disease country COVID-19 healthcare help higher risk IMPROVE limitation lockdown maintain Mental Mobile Older pandemic physical PROTECT Quality of life resource self-quarantine serious complication Smartphone social distancing Topic while [DOI] 10.5811/westjem.2020.4.47372 PMC 바로가기 [Article Type] Endemic Infections
Coping with COVID: How a Research Team Learned To Stay Engaged in This Time of Physical DistancingEditorial Published on 2020-04-172022-10-29 Journal: mBio [Category] Coronavirus, SARS, [키워드] alteration Community connection coping COVID-19 COVID-19 pandemic maintain Mentoring pandemic physical distancing physically Research research lab SARS CoV-2 social distancing team time Virology [DOI] 10.1128/mBio.00850-20 PMC 바로가기 [Article Type] Editorial
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping reviewScoping Review Published on 2020-03-172022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed Antiviral treatment article association avoidance cause causes Characteristics China Chinese Clinical diagnosis concern conducted confirmed cases connection Contact Contact tracing coronavirus disease cough country COVID-19 deaths Diagnosis diarrhea domains Dyspnea Emergency English language Epidemic Epidemiology fatigue Fever headache hemoptysis hygiene include information majority Masks methodological MOST Novel coronavirus outbreak Pneumonia Prevention and control preventive measure proportion Public public health emergency quarantine reduce Research Respiratory illness Result review shown spread to suggested supportive care Symptom Symptomatic treatment Transmission virus World Health Organization Wuhan [DOI] 10.1186/s40249-020-00646-x PMC 바로가기 [Article Type] Scoping Review
Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality포도당 억제, 병원성 특성 및 SNF1 본질에서 Candida albicans Mig1 및 Mig2의 역할Research Article Published on 2020-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addition biofilm Candida Candida albican Candida albicans carbon carbon metabolism carbon source Cell cell wall colonize connection Control distinctive features endothelial cells eukaryotic explain expression feature function fungal Gene Expression Gene regulation Genes Genetic Glucose help Host hyphae identify include indication Infection inhibitors Macrophage mediators metabolic metabolism opportunistic pathogen organism ortholog orthologs pathogen pathogenicity pathway Protein protein kinase regulated Regulation repressed required role Saccharomyces cerevisiae second tissues Tolerance traits transcription factor transcription factors unique viability yeast [DOI] 10.1371/journal.pgen.1008582 PMC 바로가기 [Article Type] Research Article