miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
A Mechanism of Gene Amplification Driven by Small DNA Fragments작은 DNA 조각에 의한 유전자 증폭 메커니즘Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amplification amplified amplify annealing Author Cancer cancer cell Cancer cells capture cause Cell chromosomal chromosomal DNA chromosomal region contribute copy number degenerative dependent on detected disorders DNA DNA amplification DNA fragment driving duplication Efficiency elevated event events expression Extracellular Factor favor found fragment Frequency gene amplification Genetic variation genomic homology Human increase independent independent of initiated involved loci mechanism molecular molecular mechanism molecular mechanisms nucleotide nucleotides occur oligonucleotide Organisms Patients with cancer polymorphism Rad1 Rad51 Rad52 regions S. cerevisiae Saccharomyces cerevisiae serum single-stranded stimulate Trigger triggered Variation yeast [DOI] 10.1371/journal.pgen.1003119 PMC 바로가기 [Article Type] Research Article
Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution PathwayResearch Article Published on 2008-11-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 80R activity amino acid change analysis Anti-viral Anti-viral therapy Author block caused CDR Combination complementarity determining region component Cytidine deaminase dominant driving effective elicited Epidemic epitope escape mutant escape mutants escape mutation Evidence Evolution found generate human convalescent sera immune immune pressure IMPROVE Infected Infectious disease information introduced investigated Mutagenesis NAb natural infection neutralization neutralization activity neutralizing antibody non-immune outbreak pathway Pathways Positive selection Protein provided response responses against responsible SARS coronavirus SARS-CoV SARS-CoV spike protein Somatic Spike protein strain Strategy Support Therapies transfer Transmission viral variant virus virus viruses while zoonotic zoonotic transmission [DOI] 10.1371/journal.ppat.1000197 PMC 바로가기 [Article Type] Research Article