Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?Article Published on 2018-10-082023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Adaptive immune response androgens Estrogens HBV HCV innate immune response progesterone Sex [DOI] 10.3389/fimmu.2018.02302 PMC 바로가기
Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunityResearch Published on 2018-08-082022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate Activation Adaptive immune response adaptive immune responses addition adjuvant AMP AMPs antibody Antigen antimicrobial peptide Antiviral antiviral immunity cells chemokine Defense dendritic cells domain effective elicited expressed expression expression level HBD Human Human β-defensin IFN-β IFN-γ IL-1β IL-6 immune Immunity immunization in vitro in vivo innate antiviral immunity innate immune innate immune response Innate immunity investigated leukocytes MERS-CoV mice microorganisms Middle East monocytes/macrophages Natural killer cells Neutralizing antibody response NOD2 PKR promote RBD Regulatory Research Result S RBD Spike protein Subunit vaccine suggested T cells THP-1 TNF-α treat Treatment viruses was used β-defensin [DOI] 10.1186/s12985-018-1035-2 PMC 바로가기 [Article Type] Research
Deep sequencing of the mouse lung transcriptome reveals distinct long non-coding RNAs expression associated with the high virulence of H5N1 avian influenza virus in miceResearch Paper Published on 2018-07-272023-05-31 Journal: Virulence [Category] Fulltext, 조류인플루엔자, [키워드] deep sequencing H5N1 influenza virus innate immune response lncRNAs Pathogenesis [DOI] 10.1080/21505594.2018.1475795 PMC 바로가기 [Article Type] Research Paper
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs살모넬라 감염 시 핵 RNA 분해 감소는 항균 비암호화 RNA를 상향 조절한다.Article Published on 2018-07-022024-08-22 Journal: The EMBO Journal [Category] 살모넬라증, [키워드] innate immune response lncRNA nuclear exosome. nuclear RNA degradation Salmonella infection
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon ResponsesResearch Article Published on 2018-05-012022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] absence antibodies Betacoronavirus caused cellular coronavirus CoV CoVs cultured cells Effect genomic genomic RNA gRNA IFN IFNAR in viral in vitro in vivo increases in Infection innate immune innate immune response innate immune system interferon interferon response interferon signaling locus marrow-derived macrophage MAVS mechanism MHV mice murine hepatitis virus mutant mutant virus Mutation not affect Nsp15 ORF1b packaged packaging signal Pathogenesis pathogenicity positive positive-sense promote receptor reduced remained replicated Replication required response restored RNA RNA molecule RNA packaging RNAs selective selective packaging significantly strain subgenomic RNAs These data TLR7 treated Type virion virions virulence virus virus replication viruses weight loss [DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia중성구 엘라스타제가 폐렴구균 폐렴에서 톨 유사 수용체와 사이토카인을 절단하여 면역 반응을 전복시킨다.Original Research Published on 2018-04-252024-08-01 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] Cytokines innate immune response Neutrophil elastase Pneumonia Streptococcus pneumoniae Toll-like receptor [DOI] 10.3389/fimmu.2018.00732 PMC 바로가기 [Article Type] Original Research
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infectionResearch Article Published on 2018-01-252022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accessory gene accessory protein acute respiratory distress antiviral response antiviral signaling ARDS binding contribute coronavirus CoV cytoplasm cytoplasmic Evidence expressed expression Fatality rate highly pathogenic host protein human CoV human infections indicate infected cells Infection information inhibited inhibiting innate immune response Interaction interfere involved Isolation KPNA4 mechanism MERS-CoV Middle East mutant NF-κB NLS nuclear nuclear localization signal nucleus pathology Pathways Prevent pro-inflammatory cytokines Protein protein complex Proteins required respiratory syndrome coronavirus retained robust severe pneumonia shown subunit syndrome translocated translocation Transport wild-type virus [DOI] 10.1371/journal.ppat.1006838 PMC 바로가기 [Article Type] Research Article
Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon- β through Its Deubiquitinase ActivityResearch Article Published on 2017-10-232022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] activity acute respiratory syndrome catalytic activity coronavirus CoV CoVs dependent on deubiquitinase DUB epidemic diarrhea Evidence expression gastroenteritis HCoV-NL63 Host host innate immunity IFN inhibit inhibited innate immune response interfere interferon interferon regulatory factor IRF3 mechanism MERS-CoV MHV Middle East murine hepatitis virus NL63 nuclear translocation PEDV Production protease respiratory SARS-CoV Sendai virus Signaling suppress TGEV virus [DOI] 10.1155/2017/7089091 PMC 바로가기 [Article Type] Research Article
A new HDV mouse model identifies mitochondrial antiviral signaling protein (MAVS) as a key player in IFN-β inductionArticle Published on 2017-10-012023-06-16 Journal: Journal of hepatology [Category] B형 간염, [키워드] AAV HDV/HBV co-infection Hepatitis B virus Hepatitis Delta virus innate immune response Liver injury mouse model [DOI] 10.1016/j.jhep.2017.05.010
Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humansarticle Published on 2017-08-142024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Adaptive immune response AS01 AS03 AS04 innate immune response interferon-γ Vaccine adjuvants [DOI] 10.3389/fimmu.2017.00943 PMC 바로가기 [Article Type] article