Phenotypic, genomic, and transcriptional characterization of Streptococcus pneumoniae interacting with human pharyngeal cells인간 인두세포와 상호 작용하는 폐렴구균의 형질, 유전체 및 전사 특성화Research Article Published on 2013-06-092024-08-04 Journal: BMC Genomics [Category] 폐렴구균 감염증, [키워드] adherence Gene Expression Genome Invasion Microarray Mutagenesis Ply operon SP_1922 Streptococcus pneumoniae [DOI] 10.1186/1471-2164-14-383 PMC 바로가기 [Article Type] Research Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
Anti- Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru저말라리아 전파 지역인 페루 로레토에서의 항 플라스모디움 팔시파룸 침입 리간드 항체Research Published on 2012-10-302024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] antibodies Invasion malaria Peru Plasmodium falciparum [DOI] 10.1186/1475-2875-11-361 PMC 바로가기 [Article Type] Research
Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate ProteoglycansResearch Article Published on 2011-08-222022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] ACE2 addition against SARS-CoV aggregation Analysis angiotensin-converting enzyme 2 binding binding site Cell cell entry cells Defense disease disrupt dose-dependent manner experiment functional Host host cell host cells Host immune response Infection inhibit inhibited inhibition inhibitory Interaction Invasion investigated involved lactoferrin neutrophil NK cell Pathogenesis prevented previous study protective role Proteoglycan pseudovirus pseudovirus infection receptor reported respiratory SARS-CoV severe shown Spike protein suggested sulfate Treatment [DOI] 10.1371/journal.pone.0023710 PMC 바로가기 [Article Type] Research Article