SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements소아에서 SARS 항체 검사: IgG 측정을 위한 구강액 분석법 개발Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval Adults antibody antibody kinetics barrier best Blood capture children collected COVID-19 development enzyme immunoassay enzyme immunoassays exposure to healthy children IgG Infection Laboratory less measurement MONITOR oral oral fluid pandemic pediatric populations primary endpoint Protein RBD RBD antigen reducing Saliva SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 surveillance SARS-CoV-2 viral School Schools sensitivity Sensitivity and specificity serum serum antibodies specificity Spike protein Spread Surveillance surveys target population Testing transudate United Kingdom venipuncture Viral were assessed [DOI] 10.1128/spectrum.00786-21 PMC 바로가기 [Article Type] Research Article
Spectral image contrast-based flow digital nanoplasmon-metry for ultrasensitive antibody detection초고감도 항체 검출을 위한 스펙트럼 이미지 대비 기반 유동 디지털 나노플라즈몬 측정Research Published on 2022-01-042022-09-10 Journal: Journal of Nanobiotechnology [Category] SARS, 진단, 치료기술, [키워드] amplification amplified Analysis Antibody assays Antibody detection artificial saliva AuNP boundary colorimetry conducted demonstrated Digital SPR FIVE gold Gold nanoparticles immunoassay immunoassays improvement Improvements limit of detection Local Local surface plasmon resonance (LSPR) magnitude Protein provide restrict Result Saliva SARS-CoV-2 scattering selectivity sensitivity signal-to-noise ratio Spectral Spectral image contrast Spike protein Spike proteins supplementary material surface plasmon surface plasmon resonance Volume [DOI] 10.1186/s12951-021-01188-6 PMC 바로가기 [Article Type] Research
Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers A Nonrandomized Controlled Trial독일 데이케어 센터의 아동 및 보육 종사자를 대상으로 한 SARS-CoV-2 감시 테스트의 타당성 비무작위 통제 시험Controlled Clinical Trial Published on 2022-01-042022-09-10 Journal: JAMA Network Open [Category] 임상, 진단, 치료기술, [키워드] 95% CI acceptance Administered age All participant All participants assigned Asymptomatic Care center Chain Reaction children children’s health clinical closure conducted continuous surveillance Controlled Controlled trial COVID-19 pandemic Day day care Day Care Centers dropout Effect Efficacy eligible feasibility Feasibility study feasible female finding Germany highest identify Importance individual Infection involved limit maintain mathematical mathematical model measure median module nasal swab nonrandomized objective on children oropharyngeal swabs pandemic parents participant participated Perception Point polymerase chain polymerase chain reaction Prevent Primary outcome Primary outcomes protocol Questionnaires Registration registry Relevance Result Saliva SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 surveillance SARS-CoV-2 testing Secondary infection secondary infections setting setup Spread Surveillance surveillance testing swabbing Testing twice weekly Viral viral spread was used worker [DOI] 10.1001/jamanetworkopen.2021.42057 PMC 바로가기 [Article Type] Controlled Clinical Trial
Performance of Rapid Antigen Tests for COVID-19 Diagnosis: A Systematic Review and Meta-AnalysisSystematic Review Published on 2022-01-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] analyses Analysis assessment asymptomatic patient calculated caused COVID-19 cycle threshold diagnostic disease early phase evaluate evaluated gold standard highest Infection Laboratory limitation literature nasal swab Nasopharyngeal swab performance polymerase chain QUADAS-2 Quality Quantitative Rapid rapid antigen test RAT RATs Registered reverse transcription review risk of bia RT-qPCR Saliva Sample SARS-CoV-2 sensitivity Sensitivity and specificity specificity symptomatic patient systematic review Test throat swab Viral RNA was performed was used [DOI] 10.3390/diagnostics12010110 PMC 바로가기 [Article Type] Systematic Review
Evaluation of Three Automated Extraction Systems for the Detection of SARS-CoV-2 from Clinical Respiratory SpecimensArticle Published on 2022-01-042022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] acid acute respiratory syndrome Affect Analysis automated extraction system Basel cause clinical Concordance contagious coronavirus coronavirus disease COVID-19 COVID-19 patients Culture detect detection DNA exhibited extraction help Inc. infectious dose Limits of detection management median molecular mRT-qPCR NPs nucleic acid extraction platform polymerase chain provided Quantitative rapid increase respiratory respiratory specimen RNA Roche RT-qPCR Saliva SARS-CoV-2 SARS-COV-2 infection sensitivity specificity sputum statistically subject Switzerland System Taiwan TCID Thermo Fisher Scientific tissue Transcription USA [DOI] 10.3390/life12010068 PMC 바로가기 [Article Type] Article
Saliva Quantification of SARS-CoV-2 in Real-Time PCR From Asymptomatic or Mild COVID-19 AdultsMicrobiology Published on 2022-01-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] age analyzed Asymptomatic charge Clinical characteristics clinical symptom co-morbidity COVID-19 COVID-19 positive patient demographics diagnosed discharge disease droplet French groups had no headache in viral Infectivity initial viral load IQR log majority median Mild nasal onset of symptom Patient PCR quantification Quantitative Real-time PCR Real-time reverse transcription PCR recruited reduction Saliva salivary SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA viral SARS-CoV-2 transmission Sex spread of COVID-19 statistically significant difference suggested Symptom Symptoms transmitted Viral load virus isolation [DOI] 10.3389/fmicb.2021.786042 PMC 바로가기 [Article Type] Microbiology
Investigation of saliva, tongue swabs and buccal swabs as alternative specimen types to nasopharyngeal swabs for SARS-CoV-2 testingSARS-CoV-2 검사를 위한 비인두 면봉의 대체 표본 유형으로 타액, 혀 면봉 및 협측 면봉 조사Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 치료기술, [키워드] alternative method Buccal Buccal swab collected diagnosis of COVID-19 diagnostic diagnostic testing initial invasive investigation less nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Patient patient group positive patient positive patients required Research Saliva saliva samples SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 testing SARS-CoV2 specimen Swab swabs tongue Tongue swab. [DOI] 10.1016/j.jcv.2021.105053 PMC 바로가기 [Article Type] Article
The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling: A systematic review and meta-analysis자가 채취한 타액 대 비인두 샘플링에서 RT-PCR의 진단 정확도: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: Saudi medical journal [Category] SARS, 치료기술, [키워드] 95% confidence interval Accuracy Analysis assessment Asymptomatic can be used characteristic coronavirus Coronavirus infections coughing COVID-19 database diagnostic Diagnostic accuracy drooling effective evaluate evaluated false false-negative False-positive Final final analysis handling medical staff Meta-analysis moderate nasopharyngeal nasopharynx Negative predictive value Odds ratio Patient Positive predictive value Predictive value Quality receiver operating characteristic resources RT-PCR Saliva sensitivity specificity specimen specimen handling spitting subgroup analysis Swab test symptomatic Symptomatic patients systematic review true true-positive utility Version were measured [DOI] 10.15537/smj.2022.43.1.20210743 PMC 바로가기 [Article Type] Meta-Analysis
Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses경증 COVID-19 환자의 바이러스 부하 해결은 선천 면역 반응 및 적응 면역 반응 모두와 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] absence acute phase Adaptive immune response all the patients antibodies antibody Asymptomatic characterized circulating collected Comorbidities Comorbidity COVID-19 COVID-19 patient COVID-19 patients Cytokines detectable dysregulation Efficiency elevated Factor had no hospitalized COVID-19 patient Host IgG IL-1β IL-6 IL-7 IL-8 immune response implicated in viral increase in Inflammation Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune response interferon Kinetics marker mediators mild COVID-19 patient mild infection Mild symptom mild symptoms Most patient Most patients neutralize Neutralizing antibodies neutralizing antibody no increase over Patient PRNT Receptor-binding domain Resolution respiratory respiratory sample Respiratory samples Saliva saliva samples SARS-CoV-2 SARS-CoV-2 viral load Seroconversion serum serum samples severe COVID-19 strain swab samples Symptom T-cell activation the patient the receptor-binding domain These data TNF-α Viral Viral load Viral RNA viral RNA detection virus isolate Virus neutralization [DOI] 10.1016/j.jcv.2021.105060 PMC 바로가기 [Article Type] Article
Mucosal immune response in BNT162b2 COVID-19 vaccine recipientsBNT162b2 COVID-19 백신 수혜자의 점막 면역 반응Clinical Trial Published on 2022-01-012022-09-12 Journal: EBioMedicine [Category] 임상, 진단, [키워드] acquisition activated Antibody titre baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine collected Concentration COVID-19 COVID-19 vaccine Department elicit ELISA entry of SARS-CoV-2 first dose generate healthcare worker highest IgA IgG immune response Immunity increase induce magnitude Medicine mRNA BNT162b2 much higher mucosal neutralizing antibody protocol Quantitative recipient Saliva Sample SARS-CoV-2 second dose seronegative seropositive individual seropositive individuals seropositive subjects serum serum IgG significantly single dose subjects supported surgery systemic immune response titre total antibody Umberto university vaccination vaccine dose virus were measured [DOI] 10.1016/j.ebiom.2021.103788 PMC 바로가기 [Article Type] Clinical Trial