Multi-conformation representation of Mpro identifies promising candidates for drug repurposing against COVID-19Mpro의 다중 구조 표현은 COVID-19에 대한 약물 용도 변경을 위한 유망한 후보를 식별합니다.Article Published on 2021-04-172022-08-31 Journal: Journal of molecular modeling [Category] SARS, 신약개발, [키워드] amrubicin antiviral drug antiviral drugs approved best candidate Cangrelor Compound conformation conformations conserved COVID-19 COVID-19 pandemic desmopressin Diosmin disease drug drug target identify inhibit inhibitor Interaction lead Ligand ligand binding pocket mechanism molecular molecular dynamics molecule MPro Novel coronavirus offer other disease pandemic protease Protein receptor Replication ribavirin Ritonavir statistically Till variety Virtual screening [DOI] 10.1007/s00894-021-04732-1 PMC 바로가기 [Article Type] Article
Early immune responses and prognostic factors in children with COVID-19: a single-center retrospective analysisResearch Article Published on 2021-04-172022-10-28 Journal: BMC Pediatrics [Category] COVID-19, MERS, [키워드] analyzed B cell Blood blood lymphocyte caused Cell cell count children children with COVID-19 concentrations conducted COVID-19 Critical critical cases cytokine Decreased diagnostic disease severity early diagnosis eosinophil ferritin group hemoglobin Hemoglobin concentration IFN-γ IL-10 IL-6 immune characteristics immune dysregulation immune response Inflammatory Inflammatory factor initial Lymphocyte count Lymphocyte subset natural killer peripheral procalcitonin procalcitonin level Prognostic factor progression RBC reduced Result Retrospective analysis Retrospective study SAA SARS-CoV-2 SARS-COV-2 infection Severe case severe disease significantly significantly increased significantly lower single-center statistically subset systemic cytokine T lymphocyte [DOI] 10.1186/s12887-021-02561-y PMC 바로가기 [Article Type] Research Article
Prevalence and factors associated with covid-19 vaccine hesitancy in Maranhão, BrazilOriginal Article Published on 2021-04-152022-10-29 Journal: Revista de Saúde Pública [Category] COVID-19, MERS, SARS, [키워드] 95%CI adopted Analysis association Brazil calculated chi-square test clinical factor Clustering conducted Conhecimentos, Atitudes e Prática em Saúde Coronavirus Infections, prevention & control cross-sectional demographic characteristics Descriptive analysis estimate Factor female Final fixed frequencies group health condition health knowledge, attitudes, practice Health Surveys Hierarchical identify independent variable individual Infecções por Coronavirus, prevenção & controle Inquéritos Epidemiológicos Intention no statistical difference Older outcome participant Pearson Prevalence random Recusa de Vacinação psicologia reported symptom SARS-CoV-2 selected statistically Stratification systematic analysis the vaccine vaccination Vaccination Refusal, psychology Vaccine hesitancy variable was performed was selected [DOI] 10.11606/s1518-8787.2021055003417 PMC 바로가기 [Article Type] Original Article
RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trialResearch article Published on 2021-04-142022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adaptive Adverse age anaphylaxis antibodies antibody assigned baseline blinded category Clinical improvement clinical scale clinical trial conducted dose double-blind Efficacy and safety Endpoint enrolled equine event finding Follow-up hazard ratio hospital hospital discharge Hospitalized hospitalized patient Immunotherapy interquartile range male Mild moderate disease Mortality multicenter neutralizing antibody Patient patients with COVID-19 patients with moderate phase 2/3 Placebo placebo-controlled placebo-controlled trial polyclonal polyclonal antibody primary endpoint Randomized Rate reached receive reported risk SARS-CoV-2 SARS-CoV-2 pneumonia severe COVID-19 Severe COVID-19 pneumonia severe disease Severe patient significantly higher statistically statistically significant difference study group subgroup analysis symptoms onset the placebo group the primary endpoint therapeutic time Treatment WHO [DOI] 10.1016/j.eclinm.2021.100843 [Article Type] Research article
The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19Physiology Published on 2021-04-122022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] affinity age Alter Altered Analysis Anemia baseline binding Blood body temperature Cell computational proteomic analysis Concentration COVID-19 COVID-19 group COVID-19 patient disease displaying exhibited expected Gas exchange gas transport groups hemoglobin hemoglobin-oxygen affinity Hemolysis hemolytic anemia Hypothesis in both groups no significant difference Non-COVID-19 non-COVID-19 group Non-COVID-19 patients not differ oxygen P50 Patient retrospective SARS-CoV-2 SCD severity Sex single-center study statistically suggested Support the disease [DOI] 10.3389/fphys.2021.578708 PMC 바로가기 [Article Type] Physiology
Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, ChinaArticle Published on 2021-04-122022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% CI adverse outcome age Analysis analyzed C-reactive protein (CRP Characteristics clinical Clinical characteristics Clinical outcome collected Comorbidities Complement C3 covariate COVID-19 patient COVID-19 patients Critical disease course disease severity Diseases Elderly patient elderly patients elevated Factor female Gender independent influence influences interquartile range laboratory data lactate dehydrogenase LDH Logistic regression Lymphocyte count median age medical records Mild multivariable analysis Odds ratio Patient patients performed proportion random risk risk factor Risk factors SAA serum amyloid severe COVID-19 severe disease course significantly higher single hospital statistically student suggested the mean Treatment unique variable Wuhan, China [DOI] 10.1038/s41598-021-82810-3 PMC 바로가기 [Article Type] Article
Assessing Uncertainty in the Rooting of the SARS-CoV-2 PhylogenySARS-CoV-2 계통발생의 기원에 대한 불확실성 평가Discoveries Published on 2021-04-092022-09-10 Journal: Molecular Biology and Evolution [Category] MERS, SARS, 변종, [키워드] approach Assessing clade CLOCK deviation Evidence identify incompatible Inference measure molecular molecular clock rooting outgroup rooting Phylogenetic Phylogeny placement root SARS-CoV-2 phylogeny SARS-CoV-2 virus Spread statistical statistically Support the SARS-CoV-2 the SARS-CoV-2 virus tree Uncertainty unlikely virus [DOI] 10.1093/molbev/msaa316 PMC 바로가기 [Article Type] Discoveries
Population-Based COVID-19 Screening in Mexico: Assessment of Symptoms and Their Weighting in Predicting SARS-CoV-2 InfectionArticle Published on 2021-04-082022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] assessment Asymptomatic COVID-19 asymptomatic patients asymptomatic subject carried Consensus COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 symptom COVID-19-related symptom Diagnosis dysgeusia early stage evaluate evaluated Fever group had no infected with SARS-CoV-2 manifestation material Musculoskeletal neurological objective oxygen saturation participant Patient positive positive result predicted ranged reduction remained representing Result RT-PCR SARS-CoV-2 SARS-COV-2 infection screened Screening sentinel significantly higher statistically study population subject Surveillance Symptoms Viral load virus spread Weighting [DOI] 10.3390/medicina57040363 PMC 바로가기 [Article Type] Article
Heterogeneous interventions reduce the spread of COVID-19 in simulations on real mobility dataArticle Published on 2021-04-082022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] activities Computer science Effect effective functions heterogeneous individual infection rate Intervention introduced Lifestyle modification lockdown Major observation pandemic reduce reducing significantly Spread spread of COVID-19 statistically the disease the SARS-CoV-2 virus [DOI] 10.1038/s41598-021-87034-z PMC 바로가기 [Article Type] Article
Dentistry Amidst the COVID-19 Pandemic: Knowledge, Attitude, and Practices Among the Saudi Arabian Dental StudentsMedicine Published on 2021-04-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Attitude Blood body fluids calculated Chi-square conducted coronavirus COVID-19 cross-sectional dental dental students dentistry evaluate help higher risk imperative knowledge majority male material mean score nonparametric test outbreak P -value pandemic participated Patient patients PPE Practice professional question questionnaire response Saliva Saudi Arabia scored seeking significantly higher social distancing SPSS statistically statistically significant student study population treat widespread [DOI] 10.3389/fmed.2021.654524 PMC 바로가기 [Article Type] Medicine