tissues – Page 38 – Communicable Diseases Research

Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney Tissue

Virus-Cell Interactions

Published on 2019-11-062022-10-30
Journal: Journal of Virology [Category] Coronavirus,

Guinea Fowl Coronavirus Diversity Has Phenotypic Consequences for Glycan and Tissue Binding

Virus-Cell Interactions

Published on 2019-03-062022-10-30
Journal: Journal of Virology [Category] Coronavirus, MERS,

[키워드] addition affected Amino acid Analysis analyzed attachment protein avian coronavirus binding cause consequence Consequences coronavirus death rate determinant Diversity evaluated Fowl France gastrointestinal tract glycan glycan receptor glycan receptors guinea fowl identity immunohistochemistry Interaction intestinal intestinal tissue intestinal tract molecular over parameter Pathogenesis pathogenicity PCR phenotypic problem produced receptor receptor affinity Recombinant S1 protein S1 protein specificity Spike protein tissue tissue tropism tissues viral tropism Virus-host interaction was in agreement
[DOI] 10.1128/JVI.00067-19 PMC 바로가기 [Article Type] Virus-Cell Interactions

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다

Research Article

Published on 2019-02-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast
[DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

급성 폐렴의 마우스 모델에서 병원체 및 모델 특이적 조직병리학의 스펙트럼

Research Article

Published on 2017-11-202022-10-28
Journal: PLoS ONE [Category] Coronavirus, 폐렴구균 감염증,

[키워드] Acinetobacter Affect caused cell types Characteristics comparison contribute coronavirus criteria Critical death distribution Escherichia coli Factor genetic background histological histopathological feature Histopathology humans IAV infectious dose Inflammatory influenza A virus Klebsiella pneumoniae Legionella pneumophila lesion lesions Lung infection MERS mice Middle East mouse model Other outcomes pathogen pathology Pneumonia pneumoniae quantification scoring system Spectrum Staphylococcus aureus Streptococcus syndrome the disease therapeutic interventions tissue tissues Treatment strategies treatment strategy
[DOI] 10.1371/journal.pone.0188251 PMC 바로가기 [Article Type] Research Article

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크

Research Article

Published on 2017-09-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes
[DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall
[DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

Potomac Horse 및 Human Sennetsu Fever의 대리인과 관련된 Neorickettsia Endobacteria로 아메리카 대륙에서 Fasciola hepatica의 게놈이 식민지를 나타냅니다.

Research Article

Published on 2017-01-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] agent America Bacteria biliary tract Biology cattle cestodes colonization Comparative genomics Complete contig disease etiological agent Evolution facilitate Fasciola hepatica Fascioliasis female reproductive tract fevers fluke food food chain Gene Expression Genome genome sequence genomes genus Health hepatica heterogeneous horizontal transmission horse Host Human humans indicated Interaction interactions involved isolate less lining liver liver fluke mammalian manuscript mechanism Migration Neorickettsia NTD NTDs offered oral sucker oral suckers organ organs parasite pathogen Pathogens pathophysiology platyhelminth potential mechanism predicted Protein reference genome reported reproductive resource ruminant ruminants schistosome seminal vesicle sequence Sequencing sheep species surface protein survival tissue tissues Transmission transmitted trematode tropical Tropical Diseases variety vertical transmission Vesicle zoonotic
[DOI] 10.1371/journal.pgen.1006537 PMC 바로가기 [Article Type] Research Article

Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes

다른 동일한 tRNA 유전자의 조직 및 시간 특이적 발현

Research Article

Published on 2016-08-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abrogate adaptive addition Affect affected age aggregation Amino acid Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans can not changes in codon codon usage conserved disease Diseases dynamic eight element expressed expression expression level expression levels fluorescent Genes genome-wide analysis GFP hallmark Host identity intrinsic intron Intronic introns lead MONITOR mutations nematodes neurodegeneration observation orthologous gene orthologous genes Pairing predict promoter promoters Protein Protein misfolding protein sequences protein translation protein-coding gene protein-coding genes recognize regulated Regulating reporter ribosome sequence synonymous tissue tissues transcribed tRNA tRNAs Tryptophan
[DOI] 10.1371/journal.pgen.1006264 PMC 바로가기 [Article Type] Research Article

Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes

인간 희귀 뼈 질환의 세 가지 개 모델의 분자 특성: 카페, 반 덴 엔데 굽타 및 레인 증후군

Research Article

Published on 2016-05-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] affected approaches associations bone candidate gene canine Cell characterization characterized children clinical feature Clinical features complementary condition conditions cortical craniomandibular osteopathy developmental developmental disorder developmental disorders disease disorders enhancer experiments expressed facilitated FAM20C feature Genes genetic cause genome-wide association Glucose homeostasis Hospital admission Hospital admissions Human hyperostosis identity include infantile cortical hyperostosis Lineage Macrophage mechanism missense variant Model molecular molecular mechanism molecular mechanisms Mortality Mutation next generation sequencing Pathogenesis pathogenic variant pathology pediatric performed phosphate provide rare disease rare diseases Research SCARF2 Sequencing skeletal SLC37A2 syndrome therapeutic therapeutic trials Therapeutics therapy tissues Treatment trials variant
[DOI] 10.1371/journal.pgen.1006037 PMC 바로가기 [Article Type] Research Article

Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila

트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다

Research Article

Published on 2016-03-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4
[DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article