Clinical features and efficacy of antiviral drug, Arbidol in 220 nonemergency COVID‐19 patients from East-West-Lake Shelter Hospital in Wuhan: a retrospective case seriesShort Report Published on 2020-10-232022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, SARS, [키워드] accelerate Adverse reactions affecting age antiviral drug Arbidol basic case sery clinical Clinical characteristics conditions contributed coronavirus disease COVID-19 COVID-19 cohort COVID-19 patient COVID‐19 patient described disease Effect Efficacy Efficiency evaluate evaluated Factor feature females Fever Gender higher risk hospital Hospital stay Infectious disease male males maximum body temperature Mild objective Patient patients respiratory specimens Result retrospective SARS-CoV-2 Symptom viral clearance [DOI] 10.1186/s12985-020-01428-5 PMC 바로가기 [Article Type] Short Report
Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19Perspective Piece Published on 2020-10-212022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] absence accelerate accelerated adaptive approach Cell clinical clinical evaluation clinical pharmacology clinical trial Combination combination therapy complementary COVID-19 COVID-19 pandemic detect drug drug combination effective Efficacy facilitated Infectious disease likelihood maintain monotherapy offer pandemic pathophysiology pathway Pharmaceutical interventions Platform trial SARS-CoV-2 second severity supported the disease therapeutic effect therapeutic options treat Treatment Trial [DOI] 10.4269/ajtmh.20-0995 PMC 바로가기 [Article Type] Perspective Piece
Rational approach toward COVID-19 main protease inhibitors via molecular docking, molecular dynamics simulation and free energy calculationArticle Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, 신약개발, 임상, 치료제, [키워드] 3CL pro 6LU7 accelerate aclarubicin acute respiratory syndrome approach binding affinity Combination Computational models Computational study coronavirus coronavirus disease COVID-19 database drug Drug discovery drug target effective identify in viral inhibitor inhibitors lack MEROPS molecular docking Molecular dynamics simulation pandemic Protease inhibitor proteinase Replication residue SARS-CoV-2 suggested target these compounds TMC-310911 Virtual drug screening virus was performed X-ray [DOI] 10.1038/s41598-020-74468-0 PMC 바로가기 [Article Type] Article
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2Article Published on 2020-10-102022-10-29 Journal: SLAS discovery : advancing life sciences R & D [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome Antiviral antivirals cell-based cleavage site clinically Confirmed confirmed case coronavirus coronavirus disease COVID-19 death determine disease drug Efficacy evaluate food global pandemic HTS identify Infection inhibitor initiated medical countermeasure Papain-like protease peptide PLPro Prevent reported SARS-CoV-2 Screening selective significantly Small molecules tested the disease the SARS-CoV-2 therapy treat triggered Vaccine [DOI] 10.1177/2472555220963667 PMC 바로가기 [Article Type] Article
Accelerated Preclinical Paths to Support Rapid Development of COVID-19 TherapeuticsReview article Published on 2020-10-012022-10-05 Journal: Cell Host & Microbe [Category] SARS, 신약개발, 치료제, [키워드] accelerate accelerated Anticoagulants antivirals approved clinical development clinical testing collected Compound COVID-19 development Drug discovery immunomodulators Pandemics path Preclinical Rapid required SARS-CoV-2 skewed Support therapeutic agent Therapeutics Trial Vaccine [DOI] 10.1016/j.chom.2020.09.017 [Article Type] Review article
Impact of Social Distancing Measures on Coronavirus Disease Healthcare Demand, Central Texas, USAExpedited Published on 2020-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, [키워드] accelerate Analysis changed Contact coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 transmission death deaths Demand Epidemiology Focusing healthcare Healthcare demand Healthcare systems hospital Hospital bed capacity hospitalizations Impact implementation intensity intensive care units Local mathematical mathematical model measure Measures pandemic Pandemics Patient Prevent reduce required respiratory infections risk SARS-CoV-2 School severe acute respiratory syndrome coronavirus 2 social distancing Social distancing measure Texas the epidemic the timing United States USA ventilator viruses zoonoses [DOI] 10.3201/eid2610.201702 PMC 바로가기 [Article Type] Expedited
Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle lossOriginal Article Published on 2020-10-012022-11-01 Journal: GeroScience [Category] COVID-19, MERS, SARS, [키워드] accelerate Appetite regulation body composition cardiovascular disease changes in chronic disease cognitive COVID-19 COVID-19 hospitalization COVID-19 pandemic CVD Depression Deterioration diabetes dietary intake disease Effect elevated Factor fat frailty Government greater Health implementation increases in Infection Inflammation Isolation likelihood lockdown measure mechanism morbidities muscle loss muscle mass obesity Older Osteoporosis physical activity populations preventative measure Protein public health authority quarantine reducing reductions in rehabilitation resistance exercise risk of COVID-19 sarcopenia social distancing Spread Stress Travel [DOI] 10.1007/s11357-020-00272-3 PMC 바로가기 [Article Type] Original Article
Using implementation science to mitigate worsening health inequities in the United States during the COVID-19 pandemicCommentary Published on 2020-10-012022-10-29 Journal: International journal for equity in health [Category] COVID-19, MERS, [키워드] accelerate Applying Community Contact tracing coronavirus disease COVID-19 COVID-19 pandemic Critical distribution effective Effectiveness Factor Factors health inequities Health inequity highlight implementation Implementation outcomes Implementation science Intervention Local mitigate outcomes pandemic populations promote Research respond response Schools Self-isolation social distancing social distancing policies Support Testing the United State The United States translation Transmission worsening [DOI] 10.1186/s12939-020-01293-2 PMC 바로가기 [Article Type] Commentary
Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between humans and mammalsBrief Report Published on 2020-09-292022-10-28 Journal: The Veterinary Quarterly [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 protein acute respiratory syndrome addition Amino acid Analysis angiotensin-converting enzyme 2 antiviral therapeutics appear binding binding region Complete conserved coronavirus COVID-19 FIVE food homologous homology Human human ACE2 humans infected with SARS-CoV-2 Infection information Interaction involved mammal Medical countermeasures mink Multiple sequence alignment Nature New York peptide Phylogenetic tree Precision Protein protein regions Quality RBD receptor Receptor binding domain reduced reported residue risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD SARS-CoV-2 transmission sequence spike glycoprotein structural homology Support the SARS-CoV-2 three-dimensional structure transmitted USA Vaccine design virus was used were infected World Health Organization [DOI] 10.1080/01652176.2020.1823522 PMC 바로가기 [Article Type] Brief Report
Antiviral Drug Discovery To Address the COVID-19 PandemicCommentary Published on 2020-09-252022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] accelerate accelerated address Antiviral agents antiviral drug approach coronavirus COVID-19 drug drug resistance effective hepatitis C virus HIV Human immunodeficiency virus inhibitor less M pro magnitude morbidity and mortality pandemic protease protease inhibitors SARS-CoV-2 [DOI] 10.1128/mBio.02134-20 PMC 바로가기 [Article Type] Commentary