Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기
Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunityArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] caused CD4+ CD4+ and CD8+ CD8+ T cell Cell cellular immunity Combination COVID-19 vaccine cytokine domain doses E. coli effective elicit elicited ELISA expressed female flow cytometry global pandemic granzyme groups IFN-γ IgG IgG1 IgG2a IL-12 IL-4 immune response immunized increase in induce infecting isotype long-lasting long-lasting neutralizing antibody lymphoproliferative mice N protein neutralization neutralization antibodies Neutralization antibody nucleocapsid percentage promoted Protective purified purified RBD quantified RBD recombinant Recombinant protein responses robust Saponin SARS-CoV-2 SARS-CoV-2 vaccine significantly spleen subcutaneously surrogate sVNT T cell response Test the SARS-CoV-2 Vaccine vaccine candidates vaccine group virus were measured [DOI] 10.3389/fimmu.2022.974364 PMC 바로가기
Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccineArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] all age group animal models Antigen approach Asymptomatic Attenuated benefit catch caused center Characteristics common cold Control did not reduce drug effective effort Engineering Express healthy Hospitalization hosts Human Human rhinovirus immune response Immunity induce Infection intranasal intranasal vaccination live vaccine Mortality mucosal nasal swab pandemic coronavirus pathogen pathogenic prevention Protective Proteins reducing Replication replication competent respiratory virus rhinovirus rhinoviruses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 serotype serum Social distancing measure Spread strain tested Vaccine vaccine candidate vector virus [DOI] 10.3389/fimmu.2022.871463 PMC 바로가기
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunityArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] antibody archive authority Breakthrough infection cellular cellular immunity Coalition Council Delta delta variant early immune response European healthy controls Horizon Human immune response in healthy individual increase in individual Infection Inflammatory mediators inflammatory parameters information interferon gamma median time Mild Neutralizing activity Norway Nucleocapsid proteins omicron Patient Protein RBD Regional Result SARS-CoV-2 sera symptom onset the receptor-binding domain the SARS-CoV-2 university vaccinated individual vaccinated individuals Vaccine vaccine dose Vaccine-induced immunity variant Whole blood [DOI] 10.3389/fimmu.2022.964525 PMC 바로가기
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severityArticle Published on 2022-09-072022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha alphacoronavirus antibodies approach Betacoronavirus caused coronavirus correlated correlation COVID-19 COVID-19 pandemic COVID-19 severity cross-reactivity Disease progression Donor Endemic endemic human coronavirus healthy controls Humoral immunity IgG response immune response infected individuals marker multiplex multiplex serology nucleocapsid nucleocapsid protein raise responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome serum serum IgG Stratification understanding Viral antigen were measured [DOI] 10.3389/fimmu.2022.889836 PMC 바로가기
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunityArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition amplified Antibody Response antigen expression attenuate B.1.351 B.1.617.2 Beta caused CD3 CD4 CD8 cell-mediated immune Cell-mediated immunity Cellular immune response Convalescent patients COVID-19 COVID-19 vaccine cytokine response Delta disease severity displaying dual-antigen saRNA vaccine elicit hamsters humoral immune response induce lower dose mice mRNA vaccine mutated N antigen Neutralizing antibody response Neutralizing antibody titer PROTECT Proteins RNA RNA vaccine S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants self-amplifying RNA spike T cell Th1 vaccination variant variants of concern Viral load [DOI] 10.1016/j.ymthe.2022.04.014 PMC 바로가기
Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성Article Published on 2022-09-052022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, [키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women [DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article
Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection StatusArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected All participant analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination approach bioinformatics blood sample BNT162b2 mRNA Characteristics collected contribute contributed controls Course COVID-19 COVID-19 vaccination COVID-19 vaccine database differentially expressed down-regulated Gene ontology Greece humoral immune response identify IgG immune response Immune status individuals infected patient KEGG knowledge Kyoto LC-MS/MS majority mechanism molecular over pandemic pathogenic pathway Pfizer/BioNTech processed profiling analysis Protein proteome proteomics provided Quantitative RBD-specific IgG recipients Research SARS-CoV-2 SARS-COV-2 infection sera serum signature significantly status the SARS-CoV-2 Thessaloniki titer vaccinated individual vaccination Vaccine virus worker [DOI] 10.3390/ijms231710153 PMC 바로가기
Antibody Course and Memory B-Cell Response in the First Year After Severe Acute Respiratory Syndrome Coronavirus 2 InfectionArticle Published on 2022-09-042022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody antibody course antibody half-life B-cell B-cells binding domain Concentration coronavirus coronavirus 2 correlated Course COVID-19 Evidence examined Frequency immune response Immunity indicate Infection Influenza virus MBC memory memory B-cell memory B-cells. Mild moderate question raise required respiratory response robust SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 NP antibody SARS-CoV-2 proteins SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 spike protein subject vaccination virus Year [DOI] 10.1093/infdis/jiac034 PMC 바로가기