Insights from nanomedicine into chloroquine efficacy against COVID-19 Comments & Opinion Published on 2020-03-232022-10-05 Journal: Nature nanotechnology [Category] SARS, 임상, 진단, 치료제, [키워드] Chloroquine COVID-19 Efficacy insight [DOI] 10.1038/s41565-020-0674-9 [Article Type] Comments & Opinion
Reverse Logistics Network Design for Effective Management of Medical Waste in Epidemic Outbreaks: Insights from the Coronavirus Disease 2019 (COVID-19) Outbreak in Wuhan (China)Article Published on 2020-03-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accelerate analyses available data China conducted coronavirus disease COVID-19 COVID-19 outbreak disease disease spread effective Effectiveness Epidemic Epidemic logistics epidemic outbreak experiment information insight knowledge logistics management Medical waste network network design operations research outbreak Outbreaks patients Quantitative recommendation Research reverse logistics risk Spread treat treated waste Wuhan Wuhan, China [DOI] 10.3390/ijerph17051770 PMC 바로가기 [Article Type] Article
Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus OutbreaksReview Published on 2020-03-042022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 2019-nCoV addition China contagious coronavirus CoV COVID-19 CoVs death develop Evolution Fatality rate genome organization Human coronavirus human CoV insight LIGHT MERS MERS-CoV Middle East novel number of infected outbreak Outbreaks public health recent reported respiratory Respiratory illness RNA virus SARS SARS-CoV SARS-CoV-2 severe viral pneumonia target cells treatment strategy virus virus Wuhan, China [DOI] 10.3390/pathogens9030186 PMC 바로가기 [Article Type] Review
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다Research Article Published on 2016-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4 [DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력Research Article Published on 2016-03-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Affect Analysis anti-neutrophil cytoplasmic antibody association Autoimmune Autoimmune diseases blood cell blood vessel blood vessels bowel Cancer cell types cellular cellular activation clinical disease complex complex system contribute cytoplasmic damage database dependent on disease risk disease-associated loci DNA Effect eQTL eQTL analysis eQTL mapping eQTLs estimate examined Examining expression expression data expression quantitative trait loci FIVE Gene Expression Genetic genetic control Genetic studies Genetic variant genetic variants genetics Genome-wide association studies Gut GWAS healthy healthy control healthy controls help Human immune system human inflammatory diseases identifying immune Immune cell immune cell type immune cells immune-mediated diseases in vitro include Infection Inflammation Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases insight investigated joint knowledge leucocyte loci majority mapping Multiple observation Pathogenesis Patient performed proportion PROTECT provide Quantitative regions resulting risk specificity subset subtype tissue tissues Treatment Type variant Vasculitis White blood cell [DOI] 10.1371/journal.pgen.1005908 PMC 바로가기 [Article Type] Research Article
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug DesignArticle Published on 2016-03-072022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis anti-CoV drug antiviral therapeutics antiviral therapy biochemical caused children complex coronavirus CoV genome CoVs Critical drug effective enzyme HCoV-NL63 Human coronavirus human CoV human CoVs Infection infections inhibitor insight isolate Lower respiratory tract M pro MERS-CoV Michael molecular mechanism molecular target Netherland NL63 Pneumonia presenting protease Proteolytic processing provide reveal RNA SARS-CoV sequence Spectrum Strains Structure Symptom treat viral replication zoonotic CoVs [DOI] 10.1038/srep22677 PMC 바로가기 [Article Type] Article
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirusArticle Published on 2014-10-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activity Biochemistry capping complex coronavirus coronavirus coronavirus RNA CoVs enzyme exonuclease Factors function Genome highlighting highly active highly pathogenic in vitro insight involved mechanism mechanisms MERS-CoV methyltransferase Middle East Molecular biology positive-sense Proofreading provided replicate Replication Research respiratory RNA RNA polymerase RNA synthesis RNA virus RNA-dependent RNA polymerase SARS Coronavirus SARS-coronavirus SARS-CoV single-stranded stimulated unique [DOI] 10.1016/j.virusres.2014.10.008 PMC 바로가기 [Article Type] Article
Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 StudiesArticle Published on 2013-04-302023-06-09 Journal: Vaccine [Category] 신종인플루엔자, [키워드] Influenza insight international observational studies pandemic (H1N1) 2009 virus [DOI] 10.1016/j.vaccine.2011.04.105 PMC 바로가기 [Article Type] Article
Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic StrategiesReview Published on 2012-11-122022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome aluminum antiseptic antiseptics-disinfectants Antiviral treatment approach Betacoronavirus biological fluids bronchitis children common cold Coronaviridae family coronavirus coronavirus described development different Efficacy emerging disease environmental condition environmental survival evaluate found HCoV 229E high risk HKU1 hospital Human human coronavirus human coronaviruses humans immunosuppressed patients Infection infections infective influence insight involved knowledge lack led to management mean methodology Neonates New NL63 nosocomial OC43 outbreak pathogen pathogenicity Pneumonia Prevent resistance respiratory diseases responsible RNA virus SARS-CoV specific treatment specificity Spread Strategy Support surgical temperature the Coronaviridae upper respiratory tract viral infections viruses [DOI] 10.3390/v4113044 PMC 바로가기 [Article Type] Review
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexResearch Article Published on 2011-10-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus [DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article