Immunogenicity and safety of different dosing schedules of trivalent inactivated influenza vaccine in pregnant women with HIV: a randomised controlled trialHIV에 감염된 임산부에서 3가 비활성화 인플루엔자 백신의 다양한 투여 일정의 면역원성과 안전성: 무작위 대조 시험Article Published on 2020-01-032022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] age All participants analysed Antenatal Antibody Response assigned Birth clinics completion computer-generated Controlled trial dose dosing schedule double-blind eligible ENhance enrolled enrolment estimated gestational age except for Final finding foundation Frequency funding gestational age greater group Group allocation HIV immunogenic immunogenicity Immunogenicity analyses immunogenicity analysis inactivated induce Infant Infants Influenza influenza vaccine Local Melinda Gate Melinda Gates mother Neonates Newborn newborn infants outcome participant pregnant women protective antibodies Protective antibody randomisation list randomised randomised controlled trial Randomly reaction receive recipient recipients recruited regimen Registered Safety Seasonal influenza seroconversion rate seroconversion rates Seven significantly higher single dose Single-dose South Africa Standard-dose strain Strains systemic reactions the vaccine three groups transfer trivalent Vaccine vaccine dose were measured with HIV women [DOI] 10.1016/S2352-3018(19)30322-4 PMC 바로가기 [Article Type] Article
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial건강한 성인에서 HIV를 예방하기 위한 아데노 관련 바이러스 매개 면역 예방: 1상 무작위 대조 시험Article Published on 2019-03-152022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] adeno-associated virus adverse event adverse events AIDS alternative analyses anti-drug antibody antibody assigned cassettes Clinical research Cohort Complete Consent detect development dose dose-escalation double-blind eligibility eligible ELISA expression finding Follow-up foundation funding Future gene delivery Gene Expression generally mild genomes groups healthy HIV HIV antibodies HIV infection immunisation induce initiative Intervention Intramuscular injection Melinda Gate Melinda Gates men moderate muscle biopsy neutralisation neutralisation activity neutralising Neutralising Antibodies neutralising antibody Phase 1 Placebo placebo-controlled Prevent provided public health quadricep quadriceps randomised randomised controlled trial Randomly reactogenicity receive Registered Research resolved RT-PCR screened Serious Adverse Event Serious Adverse Events serotype serum sustained T-cell Response T-cell responses Tolerability Trial United State United States Vaccine virus Volunteer volunteers was done were recorded [DOI] 10.1016/S2352-3018(19)30003-7 PMC 바로가기 [Article Type] Article
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial항레트로바이러스 요법(REALITY)을 시작하는 아프리카의 심각한 면역 저하 HIV 감염 개인의 사망률에 대한 즉시 사용 가능한 보충 식품의 효과: 공개, 병렬 그룹, 무작위 대조 시험Article Published on 2018-04-102022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI adverse event adverse events age analysed anti-infection Antiretroviral therapy ART assigned block size BMI body-mass body-mass index both groups CD4 cell Cell changes in children clinic visit Clinic visits computer-generated database Department development died Dispensing Effect eight Eligible participants Evidence evidence of finding funding global health GRADE greater hazard ratio high risk HIV infection hospital hypothesise Immunocompromised in both group individual individuals infected individuals infections Intention intention to treat Interaction ISRCTN ISRCTN registry Kenya log-rank Medical Research Council medication micronutrients Mortality no evidence of nutritional status Older Open-label outcome parallel-group participant Participants peanut per day Policy present Primary outcome Prophylaxis raltegravir randomisation randomised controlled trial Randomly ready-to-use therapeutic food reducing Registered reported Safety secondary Secondary outcomes Serious Adverse Event Serious Adverse Events significantly stratified sub-Saharan Africa Symptom Trial Uganda vital status weight weight gain Wellcome Trust would increase Z score Zimbabwe [DOI] 10.1016/S2352-3018(18)30038-9 PMC 바로가기 [Article Type] Article
The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial무작위 대조 시험에서 위약 사용의 윤리: Plasmodium vivax 항재발 시험 사례 연구Debate Published on 2018-03-062024-07-27 Journal: BMC Medical Ethics [Category] 말라리아, [키워드] Ethics malaria Placebo randomised controlled trial Vivax [DOI] 10.1186/s12910-018-0259-4 PMC 바로가기 [Article Type] Debate
Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trialHIV의 2차 치료를 위한 로피나비르 + 뉴클레오시드 역전사효소 억제제, 로피나비르 + 랄테그라비르 또는 로피나비르 단독요법(EARNEST): 무작위 대조 시험의 144주 추적 결과Article Published on 2018-01-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] adverse event African AID analysed Analysis Antiretroviral therapy ART assigned best clinical Combination combination therapy completion computer-generated cooperation country criteria Developing development Efficacy eligibility European event finding FIVE Follow-up funding GRADE grade 3 group HIV-infected people inferiority inhibitor inhibitors intervention group ISRCTN Kenya less limit Lopinavir Medical Research Council Modification monotherapy no difference non-inferiority non-inferiority margin nucleoside offer offered outcome participant partnership Patient per day primary analysis Primary outcome protease Protease inhibitor raltegravir randomisation randomised controlled trial Randomly receive recent regimen regimens Registered Ritonavir screened sequence Serious Adverse Events Swedish Treatment treatment of HIV Trial two-sided α Uganda Viral Viral load viral loads Virological WHO WHO criteria WHO guideline Zimbabwe [DOI] 10.1016/S1473-3099(17)30630-8 PMC 바로가기 [Article Type] Article
Economic incentives for HIV testing by adolescents in Zimbabwe: a randomised controlled trial짐바브웨 청소년의 HIV 검사에 대한 경제적 인센티브: 무작위 대조 시험Article Published on 2017-11-202022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI adjusted odds ratio Adults adverse event adverse events African Analysis Antiretroviral therapy assigned assistant blinded Care Caregivers children clinical Community Consent Controlled trial Coverage Effect eligible enrolled enrolment finding fixed funding group had no health-care HIV HIV infection HIV testing household Households Intention intention to treat investigated Local Logistic regression much lower not blinded number of children Older outcome Pan Pan African Clinical Trials Registry participant Prevalence prevention service Primary outcome proportion provided random effect randomised controlled trial Randomly receive Registered registry repeated reported Research statistician tested Trial Wellcome Trust Zimbabwe [DOI] 10.1016/S2352-3018(17)30176-5 PMC 바로가기 [Article Type] Article
Bell’s Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trialStudy Protocol Published on 2017-02-132024-09-02 Journal: BMC Pediatrics [Category] 대상포진, [키워드] bell’s palsy Child facial nerve palsy House Brackmann scale Prednisolone randomised controlled trial [DOI] 10.1186/s12887-016-0702-y PMC 바로가기 [Article Type] Study Protocol
Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trialCD4 세포 수가 μL당 500개 이상인 HIV 양성인 사람의 중증 세균 감염 위험에 대한 항레트로바이러스 요법의 즉각적인 개시 효과: 무작위 대조 시험의 2차 결과 결과Articles Published on 2017-01-052022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI AIDS allergy analysed Analysis Antiretroviral therapy ART assigned average Bacterial Bacterial infection Bacterial infections bacterial pneumonia Bildung caused CD4 cell Cell composite endpoint Cox proportional hazard Cox proportional hazards regression Cutoff death defined described disorder Effect Endpoint enrolled European explained extrapulmonary tuberculosis Factor finding Follow-up foundation funding hazard ratio Hospital admissions Immediate Increases increases in Infectious disease Infectious diseases median Medical Research Council multivariable analysis network neutrophil neutrophil count Patient Pneumonia randomised controlled trial recruited reduce reduced risk Registered required risk secondary outcome severity subgroup subgroups Trial Tuberculosis univariable analysis [DOI] 10.1016/S2352-3018(16)30216-8 PMC 바로가기 [Article Type] Articles
Influenza vaccine efficacy in young children attending childcare: A randomised controlled trialRandomized Controlled Trial Published on 2017-01-012023-05-31 Journal: Journal of paediatrics and child health [Category] A형 간염, [키워드] childcare children Influenza randomised controlled trial vaccination [DOI] 10.1111/jpc.13313 [Article Type] Randomized Controlled Trial
Interceptor® long-lasting insecticidal net: phase III evaluation over three years of household use and calibration with Phase II experimental hut outcomesInterceptor® 장기 지속성 살충망: 3년간 가정 사용에 대한 3단계 평가 및 2단계 실험 오두막 결과와의 보정Research Published on 2016-04-132024-08-12 Journal: Parasites & Vectors [Category] 말라리아, [키워드] Alpha-cypermethrin Anopheles gambiae LLIN Long-lasting insecticidal net randomised controlled trial Tanzania [DOI] 10.1186/s13071-016-1490-9 PMC 바로가기 [Article Type] Research