Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers예방 접종을 받은 의료 종사자들 사이에서 SARS-CoV-2 변종 B.1.1.7의 전파Article Published on 2021-11-012022-09-11 Journal: Infectious diseases (London, England) [Category] SARS, 변종, [키워드] acceptance acquisition age B.1.1.7 BNT162b2 Breakthrough infection breakthrough infections Cohort concerning COVID-19 COVID-19 outbreak cycle threshold diagnosed with COVID-19 Diagnosis dose effective Efficacy Gender HCW HCWs Health care worker healthcare worker In-hospital measure MOST nasopharyngeal neutralization not differ of BNT162b2 PCR positive Prospective prospective cohort reduced SARS-CoV-2 SARS-CoV-2 variant sera significantly Spread study period Symptom the disease Transmissibility Transmission vaccinated individual vaccinated individuals vaccination vaccination against COVID-19 variant Viral load viral loads were expressed [DOI] 10.1080/23744235.2021.1945139 PMC 바로가기 [Article Type] Article
Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2SARS-CoV-2의 고처리량 혈청감시를 위한 대리바이러스 중화시험 평가Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody test Antibody titer Belgium biosafety level Biosafety Level 3 Cell culture Cohort correlation COVID-19 case cPass. cPass™ cVNT Democratic Republic detect Efficacy Genscript gold gold standard healthcare worker Hospitalized immune immunoassay independent involved less level 3 Live virus Luminex MIA Mild multiplex Neutralising Antibodies neutralising antibody neutralization neutralization test Neutralizing antibodies neutralizing antibody Neutralizing antibody test performed population studies powerful tool SARS-CoV-2 screening programs sensitivity sera serological test Serological tests Serosurveillance sub-Saharan Africa surrogate virus neutralization test sVNT technique Vaccine virus neutralization test [DOI] 10.1016/j.jviromet.2021.114228 PMC 바로가기 [Article Type] Article
Assessment of antiphospholipid antibodies and calprotectin as biomarkers for discriminating mild from severe COVID-19경증에서 중증 COVID-19를 구별하기 위한 바이오마커로서의 항인지질 항체 및 칼프로텍틴의 평가Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome antibodies antibody anticardiolipin antibodies anticardiolipin antibody antiphospholipid antibodies assessment association Biomarker C-reactive protein C-reactive protein (CRP calprotectin CD4 clinically coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients CRP CRP level CRP levels detectable Detection limit elevated ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated ferritin groups healthy control healthy controls help highest Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients IgM immunoassay IMPROVE Inflammatory laboratory parameter lymphocyte Lymphocyte count management Mild moderate multiplex negative correlation neutrophil Neutrophil-to-lymphocyte ratio no significant differences not differ outcome oxygenation status parameter pathway peak levels Prevalence procalcitonin proportion respiratory distress Respiratory distress syndrome sera severe COVID-19 severe group severity significant differences significantly significantly higher syndrome T cells two group two groups were measured [DOI] 10.1002/jcla.24004 PMC 바로가기 [Article Type] Article
Harmonization of six quantitative SARS-CoV-2 serological assays using sera of vaccinated subjects백신 접종 대상자의 혈청을 사용한 6가지 정량적 SARS-CoV-2 혈청학적 분석의 조화Article Published on 2021-11-012022-09-12 Journal: Clinica chimica acta; international journal of cli [Category] MERS, SARS, 진단, [키워드] Antibody titer Antibody titers assays Characteristics Comirnaty vaccine complement correlation COVID-19 facilitate Factor harmonization IgG individuals limit material neutralization neutralization activity performed predict produced Quantitative reproducibility SARS-CoV-2 SARS-COV-2 infection sera serological Serological assay Serological standard serum sample subject tested vaccinated individual Variability were used WHO WHO. [DOI] 10.1016/j.cca.2021.08.024 PMC 바로가기 [Article Type] Article
High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2원래 변형률에 대한 중화 활동의 높은 개별 이질성 및 SARS-COV-2의 9 가지 변이체Article Published on 2021-10-282022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] activity Alpha antibodies Beta circulating convalescent individual convalescent individuals COVID-19 COVID-19 pandemic COVID-19 vaccine Delta delta variant dependent on Efficacy explained followed by France Genotype heterogeneity highest in silico approaches individual infecting Infection inter-individual isolates Lineage Local lowest mRNA mRNA-based vaccine mutant NAb NAbs natural immunity Neutralising Antibodies neutralising antibody nine original Pfizer/BioNTech recipient responsible SARS CoV2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera shown Spike protein strain summer tested titre titres Vaccine variant variants Variation virus viruses Wuhan strain [DOI] 10.3390/v13112177 PMC 바로가기 [Article Type] Article
Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamstersSARS-CoV-2와 인플루엔자 바이러스의 동시 감염은 햄스터에서 더 심각하고 장기적인 폐렴을 유발합니다Article Published on 2021-10-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjacent area body weight Body weight loss cause caused Cell cell tropism Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms fatality growth hamster hamsters Health IAV IL-6 immunohistochemical analyses in vivo Infection Infectious diseases Influenza influenza A influenza A virus Influenza virus inhibit Interference involved lung Lungs organ organs pathogen Pathogens Pneumonia Post-infection public health respiratory risk SARS-CoV-2 SARS-CoV-2-infected hamsters sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 significant increase Spread Symptom Virology virus viruses weight loss [DOI] 10.1038/s41598-021-00809-2 PMC 바로가기 [Article Type] Article
Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein MicroarrayResearch Article Published on 2021-10-272022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] accelerated accessory protein antibody antibody binding sites antibody reactivity antigenic applied binding changes in correlated correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cross-react cross-reactivity de novo ELISAs endemic human coronavirus enzyme-linked immunosorbent assay epitope Epitopes Evidence full-length HCoV HCoV-NL63 HCoV-OC43 help Human human coronaviruses identify IgA IgG IgM immune increasingly individual infect knowledge mapping MERS-CoV Microarray microneutralization Middle East Mutant SARS-CoV-2 N proteins Numerous ORF3a ORF7a other coronavirus overlapping Patient peptide Protein Proteins reactive reactivity Region regions Research respiratory syndrome coronavirus response responses responses against SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sera shown specificity Spread structural protein the antibody response vaccination Vaccine-induced immunity variants of concern viral evolution viruses was used worldwide pandemic [DOI] 10.1128/Spectrum.01416-21 PMC 바로가기 [Article Type] Research Article
Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for Accurate and Prompt Coronavirus Disease 2019 (COVID-19) Diagnosis Using the Rational Selection of Serological BiomarkersArticle Published on 2021-10-232022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] added alkaline antibodies antibody Antigen antigens capture antigen Combination comparable controls COVID-19 COVID-19 diagnosis cut-off value develop development diagnostic ELISA evaluated IgA IgG IgG antibodies IgM incubated infection control Measures optical Patient Plate protein antigens RBD required SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 protein Selection sensitivity Sensitivity and specificity sera serological serological test Serological tests specificity Standard deviation Support the mean was determined [DOI] 10.3390/diagnostics11111970 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Antibody Binding and Neutralization in Dried Blood Spot Eluates and Paired Plasma건혈 반점 용출액 및 짝을 이루는 혈장에서 SARS-CoV-2 항체 결합 및 중화Research Article Published on 2021-10-202022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, [키워드] 384-well format acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adoption ambient ambient temperature antibodies antibody Antibody binding Antibody Response Antibody responses binding Blood cold chain cold temperatures collected convalescent coronavirus correlated COVID-19 COVID-19 pandemic Critical dried blood spot Dried blood spots ELISA Eluate enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope epitope mapping equipment evaluate feature fingerstick immune response immune responses Infection invasive Longevity MOST natural infection neutralization assays Neutralizing antibodies neutralizing antibody overcome phage display plasma plasma antibody Population profile reflected respiratory responses risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 neutralization SARS-CoV-2 variant sera severe acute respiratory syndrome Coronavirus specific antibodies spot storage Support temperature vaccinated individuals vaccination variety venipuncture venous venous blood while [DOI] 10.1128/Spectrum.01298-21 PMC 바로가기 [Article Type] Research Article
Emerging SARS-CoV-2 Variants: A Review of Its Mutations, Its Implications and Vaccine EfficacyReview Published on 2021-10-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect antibody B.1.1.7 B.1.351 B.1.525 B.1.526 B.1.617.2 CDC center Characteristics characterized circulating close monitoring concerning Control Coronavirus-2 COVID-19 Efficacy Health highlight immune impair increase in Mutation mutations neutralization P.1 P.2 prevention Reinfection review SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera several variant severe disease the United State Transmissibility vaccinated individual Vaccine Vaccines variant variants of concern variants of interest virus widespread [DOI] 10.3390/vaccines9101195 PMC 바로가기 [Article Type] Review