Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial중증 코로나19 환자에서 이카티반트 및 C1 에스테라제/칼리크레인 억제제의 효능 및 안전성 평가: 3군 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-01-202022-09-10 Journal: Trials [Category] 비임상, 임상, [키워드] accumulation ACE inhibitor ACE inhibitors ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models anti-inflammatory agents antibiotic antithrombotic therapy assigned binding bradykinin breath C1 esterase inhibitor cause Cell clinical clinical trial clinical trials cough COVID-19 Degradation dependent on driving Efficacy and safety eligible patient expressed Icatibant inactivation include Inflammatory inhibitor intravenously invasive ventilation leads lipopolysaccharide LPS lung lung inflammatory response Lungs mechanism mortality rates Non-invasive number Open-label oxygen parallel-group Pneumonia Pneumonitis Prophylactic Protein randomized clinical trial Randomized controlled trial Randomly receive reduce registry renal replacement therapy replacement therapy Respiratory failure SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients Severity of disease Side effect single-center standard care Study protocol subcutaneously supplemental oxygen the cells Universal vasopressor support viral-induced virus [DOI] 10.1186/s13063-021-05027-9 PMC 바로가기 [Article Type] Study Protocol
Clinical characteristics of 14 COVID-19 deaths in Tianmen, China: a single-center retrospective studyResearch Article Published on 2021-01-202022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] Acute kidney injury acute respiratory distress Admission age analyzed ARDS C-reactive protein cardiovascular disease Characteristics Chest CT chronic disease Chronic kidney disease clinical Clinical characteristics Comorbidities cough COVID-19 Critically ill patient CRP death deaths died Dyspnea elderly elevated epidemiological evaluated Factors Fever General symptom had more healthcare high risk Hospitalized hypertension increased risk Injury IQR Laboratory liver dysfunction lymphocyte median men Most patient Older onset of symptom organ dysfunction Patient radiological reduced Region reported resource Result Retrospective study SARS-CoV-2 SARS-CoV-2-infected patient severe pulmonary lesions significantly single-center supplementary material symptomatic syndrome the median Treatment with COVID-19 Wuhan [DOI] 10.1186/s12879-021-05770-z PMC 바로가기 [Article Type] Research Article
Pragmatic, open-label, single-center, randomized, phase II clinical trial to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus in patients with severe pneumonia secondary to COVID-19: The TACROVID trial protocolArticle Published on 2021-01-192022-10-04 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] 1:1 Arm assigned body temperature clinical clinical trial Coronavirus infection COVID-19 COVID-19 disease COVID-19 patient Cytokine storm defined drug drug combination effective Efficacy and safety evaluate Hyperinflammatory Hyperinflammatory syndrome Immunomodulatory agent Inflammation inhibit Lung injury Methylprednisolone Open-label paO2/fiO2 Patient pulmonary failure pulse randomization Randomized Randomly Replication respiratory rate Safe SARS-CoV-2 severe COVID-19 patients severe lung injury severe pneumonia single-center SOC stability Standard of care subsequent suggested tacrolimus treat treated Trial trial protocol triggered working hypothesis [DOI] 10.1016/j.conctc.2021.100716 PMC 바로가기 [Article Type] Article
Clinical and laboratory features of hypercoagulability in COVID-19 and other respiratory viral infections amongst predominantly younger adults with few comorbiditiesCOVID-19 및 기타 호흡기 바이러스 감염에서 과응고 가능성의 임상 및 실험실 특징은 동반 질환이 거의 없는 주로 젊은 성인에서Article Published on 2021-01-192022-09-10 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] activated activated partial thromboplastin time Analysis approach Biomarkers caused changes in clinical Coagulation Coagulation parameters Comorbidity Course COVID-19 Epidemiology event Factors haemostasis highest hospitalized COVID-19 patient hypercoagulability Infection Infectious diseases Laboratory laboratory feature Mild Mild disease Myocardial infarction not differ occurred parameter partial thromboplastin time Patient patients pharmacological profiles Prothrombin time prothrombotic reported Research respiratory respiratory viral respiratory viral infection retrospective cohort study risk SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 significantly higher single-center Thromboprophylaxis thrombotic Thrombotic complications Thrombotic events two group venous Viral viral infection with mild disease [DOI] 10.1038/s41598-021-81166-y PMC 바로가기 [Article Type] Article
Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central SpainArticle Published on 2021-01-162022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission age carried chronic obstructive cohort study Community comorbid condition Comorbidity COPD COVID-19 cumulative death Factor First wave hospital hospitals In-hospital death in-hospital mortality Infection Inpatient LDH lymphopenia males marker medical record Mortality Multivariate analysis pandemic Patient Population predictors pulmonary disease remained retrospective Risk factors rural population serum creatinine severe coronavirus disease severe SARS-CoV-2 single-center Spain [DOI] 10.3390/jcm10020318 PMC 바로가기 [Article Type] Article
Medical treatment of 55 patients with COVID-19 from seven cities in northeast China who fully recovered A single-center, retrospective, observational study중국 동북부 7개 도시에서 완전히 회복된 COVID-19 환자 55명에 대한 의료 치료 단일 센터, 후향적, 관찰 연구Observational Study Published on 2021-01-152022-09-10 Journal: Medicine [Category] 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Antibiotics antiviral drug antiviral drugs antiviral therapy benefit caused China Clinical outcome clinical outcomes Co-infection collected Controlled trial controlled trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demographics double-blind drug early administration effective emerging disease glucocorticoid Glucocorticoids immunomodulators Intervention Laboratory Linezolid Lopinavir Lopinavir/ritonavir lopinavir/ritonavir) median medical treatment medication Mild mild symptoms moxifloxacin observational study Patient patients with COVID-19 reduce respiratory retrospective risk Ritonavir SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe group severe symptoms single-center Symptoms the disease transferred treat treated Treatment umifenovir [DOI] 10.1097/MD.0000000000023923 PMC 바로가기 [Article Type] Observational Study
Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homesResearch Article Published on 2021-01-152022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] Admission age analyzed association Blood Bonferroni correction Care categorical variable caused clinical outcomes Comorbidities Comorbidity computer tomography COVID 19 develop diagnosis of COVID-19 disease elderly Elderly patient examined Factors FiO2 Fisher’s exact test Hospital stay increased mortality index inflammatory activity information inspired oxygen fraction Kaplan-Meier method Laboratory tests Logistic regression LOS manifestation Mann-Whitney U test mortality rate multiple comorbidities multiple group multivariate Occurrence outbreak outcome oxygen P/F PaO2 Patient patients patients older performed PSI radiological finding RANK Residential care homes Result Retrospective study risk factor risk stratification Rome SARS-CoV-2 Severity of disease Sex single-center survival susceptible Symptom Test the disease two group university variables viral shedding Wilcoxon signed-rank test [DOI] 10.1186/s12877-021-02013-3 PMC 바로가기 [Article Type] Research Article
Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homesResearch Article Published on 2021-01-152022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, [키워드] Admission age analyzed association Blood Bonferroni correction Care categorical variable caused clinical outcomes Comorbidities Comorbidity computer tomography COVID 19 develop diagnosis of COVID-19 disease elderly Elderly patient examined Factors FiO2 Fisher’s exact test Hospital stay increased mortality index inflammatory activity information inspired oxygen fraction Kaplan-Meier method Laboratory tests Logistic regression LOS manifestation Mann-Whitney U test mortality rate multiple comorbidities multiple group multivariate Occurrence outbreak outcome oxygen P/F PaO2 Patient patients patients older performed PSI radiological finding RANK Residential care homes Result Retrospective study risk factor risk stratification Rome SARS-CoV-2 Severity of disease Sex single-center survival susceptible Symptom Test the disease two group university variables viral shedding Wilcoxon signed-rank test [DOI] 10.1186/s12877-021-02013-3 PMC 바로가기 [Article Type] Research Article
Comparison of clinical characteristics among younger and elderly deceased patients with COVID-19: a retrospective studyResearch Paper Published on 2021-01-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] Acute cardiac injury age anorexia Campus chronic cardiac disease Clinical characteristics clinical feature collected Comorbidity Complication confidence interval COVID-19 COVID-19 patient COVID-19 patients Deceased demographic demonstrated described develop Fever interquartile range median age medical records multivariate analyses Odds ratio Patient patients protective factor Retrospective study risk factor SARS-CoV-2 single-center subjects Union Hospital West Wuhan [DOI] 10.18632/aging.202139 PMC 바로가기 [Article Type] Research Paper
Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19심각한 COVID-19 환자를 위한 임상 의사 결정 지원 프로토콜 내에서 염증 조절을 돕는 바이오마커로서의 IP-10의 잠재력에 대한 관찰 코호트 연구Clinical Trial Published on 2021-01-122022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Biomarker clinical decision cohort study coronavirus correlated Corticosteroid corticosteroid immunomodulatory therapy COVID-19 patient COVID-19 patients COVID-19-related complications died disease stage disease stages host protein host-pathogen interaction hyperinflammation immune immunoassay immunomodulatory therapy Inflammation intensive care intensive care unit interferon involved IP-10 Lung injury management Mortality Oxygenation Patient performed platform protocol quantitative measurement Registered Regulation respiratory Result severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severely ill COVID-19 patients Severity Score significantly single-center subsequent Support therapeutic utility Viral viral clearance virus-induced hyperinflammation while with COVID-19 γ-induced protein 10 [DOI] 10.1371/journal.pone.0245296 PMC 바로가기 [Article Type] Clinical Trial