Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014Expedited Published on 2015-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Admission Affect age cause clinical outcomes Clinical severity cycle threshold death decrease determine died E gene evaluated intensive care load median MERS-CoV Middle East Middle East respiratory syndrome Coronavirus modulation multivariable nasopharyngeal specimen outcome Patient patients positive Regression analyses respiratory syndrome coronavirus Result reverse transcription PCR risk factor Saudi Arabia significantly lower survivor tested the median therapeutic agent upstream virus virus load viruses zoonoses [DOI] 10.3201/eid2111.150764 PMC 바로가기 [Article Type] Expedited
Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected MacaquesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication [DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article
The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing ChineseResearch Article Published on 2007-06-012022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Admission Affect antiviral action association Beijing Chinese controls death examined G allele Genotype Hong Kong increased risk individual Inflammation intensive care unit IP-10 outcome Pathogenesis polymorphism RANTES Replication Result risk of death SARS patient susceptibility tested [DOI] 10.1186/1471-2334-7-50 PMC 바로가기 [Article Type] Research Article