The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus InfectionResearch Article Published on 2016-12-132022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] abrogate acute respiratory syndrome ADP-ribose ADP-ribosylation antiviral property Cell culture changes in conserved coronavirus Coronavirus infection CoVs disease domain elicited enzyme epithelial cell line help highly pathogenic human CoV IFN Impact in viral in vitro Inclusion Infection Innate innate immune response Innate immunity interferon interferon-stimulated gene ISG lethal disease macrodomain mechanism mice Modification mutant virus Mutation mutations nonstructural protein 3 Nsp3 Pathogenesis positive-sense Proinflammatory cytokine promote PROTECT Protein protein targets Proteins reduced reducing reduction regulate Regulation Replication respiratory response RNA viruses SARS-CoV SARS-CoV infection strain suppressed target therapy understanding Viral load virulence virus virus attenuation [DOI] 10.1128/mBio.01721-16 PMC 바로가기 [Article Type] Research Article
Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes다른 동일한 tRNA 유전자의 조직 및 시간 특이적 발현Research Article Published on 2016-08-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate adaptive addition Affect affected age aggregation Amino acid Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans can not changes in codon codon usage conserved disease Diseases dynamic eight element expressed expression expression level expression levels fluorescent Genes genome-wide analysis GFP hallmark Host identity intrinsic intron Intronic introns lead MONITOR mutations nematodes neurodegeneration observation orthologous gene orthologous genes Pairing predict promoter promoters Protein Protein misfolding protein sequences protein translation protein-coding gene protein-coding genes recognize regulated Regulating reporter ribosome sequence synonymous tissue tissues transcribed tRNA tRNAs Tryptophan [DOI] 10.1371/journal.pgen.1006264 PMC 바로가기 [Article Type] Research Article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research