Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In VitroResearch Article Published on 2022-01-152022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, SARS, [키워드] ACE ACE2 acute respiratory syndrome alcohols approach Bacteria Caco-2 cell Camostat mesylate Chloroquine coronavirus Critical demonstrated develop entry of SARS-CoV-2 Formulation host cell host cells human host cells Increasing Infection inhibit inhibitor Interaction mechanism membranes multitude Naturally novel outbreak pandemic pathogenic virus pathological performed plasma membrane proliferation promoted receptor ACE2 reduce Remdesivir SARS-CoV-2 SARS-CoV-2 replication saturated serine protease TMPRSS2 Spread time-consuming TMPRSS2 Vaccines viral infectivity viral S protein virus [DOI] 10.1155/2022/1558860 PMC 바로가기 [Article Type] Research Article
Angiotensin-Converting Enzyme Genotype–Specific Immune Response Contributes to the Susceptibility of COVID-19: A Nested Case–Control StudyPharmacology Published on 2022-01-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE acute respiratory syndrome Angiotensin-converting enzyme Chinese complement control group coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 vaccine cytokine Cytokine storm demonstrated detect distribution drug design ELISA kit Genotype global pandemic identify immune immune response lung Mild moderate Odds ratio pathway Patient plasma proteomics polymerase chain polymorphism Precision protein expression proteomics regression analysis response SARS-CoV-2 severe symptom susceptibility [DOI] 10.3389/fphar.2021.759587 PMC 바로가기 [Article Type] Pharmacology
Disorders of the Cholinergic System in COVID-19 Era—A Review of the Latest ResearchReview Published on 2022-01-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE Acetylcholine acetylcholinesterase agonist angiotensin-converting enzyme 2 antiviral drug antiviral drugs binding can be used cause caused change cholinergic cholinergic system complex conducted connection COVID-19 COVID-19 virus cytokine production Cytokine storm demonstrated develop disorder disrupt dysregulation Effect epitope example in vitro in vivo inhibit initiated Morphological negative influence nervous system Nicotine nicotinic receptors Non-invasive physiological Prevent receptor reduce Research review SARS-CoV-2 SARS-CoV-2 spike protein sequence Structure System the SARS-CoV-2 virus therapy these compound virus [DOI] 10.3390/ijms23020672 PMC 바로가기 [Article Type] Review
Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach전통 인도 의학에 의한 COVID-19에 대한 면역 체계의 활성화 메커니즘 이해: 네트워크 약리학 접근Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] ACE activating acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alarm Algorithm alternative medicine approach approved betulinic acid biological process cathepsin cathepsin B cathepsin L cellular clinical trials Compound compounds coronavirus 2 COVID-19 COVID-19 infection determine disease DPP4 drug drug design drug target effective EGFR Emergency use enrichment analyses enrichment analysis Evolution functions gene-gene interaction globe HDAC2 identify IL6 immune system Interaction involved JACOM Kabasura kudineer mechanism medication Medicine molecular docking studies Molecular docking study molecular functions Mutation network network pharmacology Nilavembu kudineer pandemic pathway Pathways performed phenyl plant plants Potential treatment predict raising respiratory RIPK1 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects target targets the SARS-CoV-2 Traditional Traditional Indian Medicine. Transmission transmissions treat treating COVID-19 understanding Vaccine VEGFA Virtual screening was used [DOI] 10.1016/bs.apcsb.2021.11.007 PMC 바로가기 [Article Type] Article
Interactions of Renin-Angiotensin System and COVID-19: The Importance of Daily Rhythms in ACE2, ADAM17 and TMPRSS2 ExpressionReview Published on 2021-12-302023-07-01 Journal: Physiological research [Category] SARS, [키워드] ACE circadian Gender hypertension Ontogenesis [DOI] 10.33549/physiolres.934754 PMC 바로가기 [Article Type] Review
Sex differences in the lung ACE/ACE2 balance in hypertensive ratsCardiovascular System & Vascular Biology Published on 2021-12-222022-10-28 Journal: Bioscience Reports [Category] COVID-19, [키워드] accelerate ACE ACE2 ACE2 gene ACE2 mRNA ACE2 protein Ang II Angiotensin II Angiotensin-(1-7) Angiotensin-converting enzyme angiotensin-converting enzyme 2 blood pressure coexpressed Concentration conducted coronavirus disease COVID-19 down-regulation evaluated expression female four group Genotype-Tissue Expression project Human hypertension hypertensive hypertensive patient Hypothesis lung Lung injury Lungs male Male sex mRNA level normotensive occur pathway promote Protein reduced respiratory infections sexual dimorphism significantly higher subjects tested tissue damage tissues [DOI] 10.1042/BSR20211201 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID-19Observational Study Published on 2021-12-212022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] 95% CI ACE ACE inhibitors ACEi/ARB adjusted hazard ratio Affect Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors association biomarkers of inflammation blood pressure C-reactive protein cell entry receptor clinical COVID-19 COVID‐19 death deaths dialysis dose examined Hospitalization In-hospital In-hospital death inclusion criteria Inflammation lower risk Measures mechanical ventilation modulating Mortality multivariable analysis need for dialysis outcome outcomes Patient patients hospitalized receptor Registration required Result SARS-CoV2 serum creatinine symptomatic thought Treatment Trial Ventilation [DOI] 10.1161/JAHA.121.023535 PMC 바로가기 [Article Type] Observational Study
Depression and anxiety symptoms and perceived stress in health professionals in the context of COVID‐19: Do adverse childhood experiences have a modulating effect?Original Article Published on 2021-12-152022-10-28 Journal: Brain and Behavior [Category] COVID-19, SARS, [키워드] ACE ACEs Acute stress Administered Adults Adverse adverse childhood experiences Analysis antecedent Anxiety anxiety symptom Care childhood collected COVID‐19 COVID‐19 Depression female gender Health Health professionals health worker high risk higher risk increase majority Mental disorder Mental Disorders mental health mental health disorders mental health problem modulate modulating outcome pandemic Patient Perceived stress problem professional Result risk SARS‐CoV‐2 significantly [DOI] 10.1002/brb3.2452 PMC 바로가기 [Article Type] Original Article
ACEs family genes: Important molecular links between lung cancer and COVID‐19ACE 가족 유전자: 폐암과 COVID-19 사이의 중요한 분자 연결Letter to Editor Published on 2021-12-152022-09-10 Journal: Clinical and Translational Medicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE COVID‐19 lung cancer molecular [DOI] 10.1002/ctm2.615 PMC 바로가기 [Article Type] Letter to Editor
Virtual Screening in Search for a Chemical Probe for Angiotensin-Converting Enzyme 2 (ACE2)안지오텐신-수색 효소 2 (ACE2)에 대한 화학 프로브 검색의 가상 스크리닝Article Published on 2021-12-142022-08-31 Journal: Molecules [Category] SARS, 신약개발, [키워드] ACE ACE2 ACE2 receptor angiotensin-converting enzyme 2 Chemical compounds CPU time demonstrated Drug discovery Efficacy evaluate in silico inhibitors management molecular docking molecular probe probe protocol REAL database SARS-CoV-2 saving Screening Virtual screening [DOI] 10.3390/molecules26247584 PMC 바로가기 [Article Type] Article