ACE2 mRNA
[용어속성] Molecule
MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection
Priority Research Paper
[키워드] ACE2
ACE2 expression
ACE2 mRNA
Affect
airway epithelial cells
antiviral agent
attenuate
bronchial epithelial cells
Cell
cells
cellular
COVID-19
COVID-19 severity
cytokine
cytotoxicity
Disease progression
elevated
expression
G-CSF
human cells
IL-1α
IL-6
immune response
in some
increase
individual
Inflammatory cytokine
inflammatory cytokines IL-6
inhibit
killing
lentiviral
lung cancer
M-CSF
MAPK
MCP-1
MEK inhibitor
natural
NK cells
NK-cell
observed correlation
pathway
Patient
Patients with cancer
plasma
Population
pRB
proliferative
promote
Protein
pseudovirus
pseudovirus infection
reduce
Regulation
Remdesivir
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 virus
SARS-CoV-2-S
stimulate
stimulated
suppress
suppressed
TMPRSS2
TMPRSS2 protease
TRAIL
treated
[DOI] 10.18632/oncotarget.27799 PMC 바로가기 [Article Type] Priority Research Paper
[DOI] 10.18632/oncotarget.27799 PMC 바로가기 [Article Type] Priority Research Paper
Comparative analysis of SARS-CoV-2 receptor ACE2 expression in multiple solid tumors and matched non-diseased tissues
다발성 고형종양 및 비병적 조직에서 SARS-CoV-2 수용체 ACE2 발현 비교 분석
Comparative Study
[키워드] ACE2
ACE2 expression
ACE2 mRNA
acute respiratory syndrome
Cancer
cellular entry
characterized
Comparative analysis
coronavirus
eight
expression
global public health
high risk
host cell receptor
lung
Non-diseased tissues
Patient
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 receptor
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Solid
solid tumor
solid tumors
tissue
tissue sample
tissues
Treatment
tumors
[DOI] 10.1016/j.meegid.2020.104428 PMC 바로가기 [Article Type] Comparative Study
[DOI] 10.1016/j.meegid.2020.104428 PMC 바로가기 [Article Type] Comparative Study
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2
SARS-CoV-2의 진입 수용체인 지오텐신 전환 효소 2의 생물정보학적 특성화
Research Article
[키워드] ACE2
ACE2 gene
ACE2 mRNA
age and gender
Analysis
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
angiotensin-converting enzyme 2
binding site
Bioinformatic
bioinformatics
caused
Cell
cell type
cell types
ciliary
classical
club
COVID-19
COVID-19 epidemic
duodenum
endothelial
entry receptor
enzyme
epithelial
epithelial cells
expressed
expression
functions
Gene ontology analysis
goblet
goblet cells
Health Organization
highest
immunohistochemistry
include
indicated
interferon-stimulated response element
International
IRF8
IRF9
kidney
lung
Novel coronavirus
novel coronavirus SARS-CoV-2
Ontology
organ
pandemic
positive
predict
promoter
promoters
Protective
public health emergency
Regulation
Renin
renin-angiotensin system
respiratory
respiratory tract
SARS-CoV-2
signal
small intestine
Stat1
suggested
target cell
target cells
Testis
Trachea
transcription factor
transcriptional regulation
Vascular
vessel
World Health Organization
[DOI] 10.1371/journal.pone.0240647 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pone.0240647 PMC 바로가기 [Article Type] Research Article
Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients
Research article
[키워드] ACE2
ACE2 mRNA
association
AUC
Biochemistry
Biomarkers
Clinical genetics
confirmed case
Contact
COVID-19
COVID-19 patient
COVID-19 patients
DPP4
elevated
EMILIN1
EMILIN2
expression
expression level
expression of SARS-CoV-2
functional
genetics
genomic
Genomic biomarkers
Host
Host invasion genes
Invasion
knowledge
less
MMRN1
MMRN2
Molecular biology
mRNA
nasopharyngeal
oropharyngeal swab
overexpression
patients
positive
profile
raised
SARS-CoV-2
SARS-CoV-2 infections
severe COVID-19
severe COVID-19 patient
severe symptom
subject
subjects
the SARS-CoV-2
TMPRSS2
Virology
with COVID-19
[DOI] 10.1016/j.heliyon.2020.e05143 [Article Type] Research article
[DOI] 10.1016/j.heliyon.2020.e05143 [Article Type] Research article
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
Research Paper
[키워드] ACE2
ACE2 mRNA
ACE2 protein
Alveolar Type II
alveolar type II cells
apical surface
association
caused
Cell
children
ciliated cells
cofactor
coronavirus
correlation
COVID-19
COVID-19 pandemic
determine
disease
disease severity
evaluated
examined
expression
Factor
Factors
finding
highest
Host
human respiratory tract
immunohistochemistry
incidence
interactions
Lower respiratory tract
lung
lung parenchyma
material
mRNA abundance
Numerous
offer
outbreak
protein levels
question
raise
receptor
receptor ACE2
reduced
Region
responsible
risk factor
SARS-CoV-2
SARS-CoV-2 susceptibility
SARS-CoV2
severe COVID-19
severe disease
Single-cell RNA sequencing
subset
susceptibility
tissue
TMPRSS2
Transmission
transmitted
Viral transmission
[DOI] 10.1016/j.ebiom.2020.102976 PMC 바로가기 [Article Type] Research Paper
[DOI] 10.1016/j.ebiom.2020.102976 PMC 바로가기 [Article Type] Research Paper
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2
Observation
[키워드] ACE2
ACE2 mRNA
ACE2 protein
activity
acute respiratory syndrome
angiotensin-converting enzyme 2
Antiviral
antiviral action
antiviral activity
antiviral drug
antiviral gene
approved
benefit
bronchial epithelial cells
canonical
Cell
cell line
clinical trial
clinically
coronavirus
coronavirus disease
counterbalance
COVID-19
COVID-19 therapeutics
Critical
cytokine
deaths
dose-dependent manner
Ebola virus
Effect
effector
elevated
ENhance
entry receptor
exacerbate
exhibited
expression
help
hepatitis C virus
highlight
HIV
Host
human lung
I, II
IFN
IFN treatment
IFN-β
IFN-γ
IFN-λ
IFN-λ1
IFNs
immune
Immunotherapy
Infection
inhibited
Innate immune defense
interferon
interferons
investigated
ISG
ISG response
ISGs
limit
mechanism
mRNA
pandemic
produced
raising
receptor
receptors
repurposing
Respiratory Coronavirus
SARS-CoV-2
SARS-CoV-2 replication
Severe infection
Side effects
surface protein
the SARS-CoV-2
therapy
Threats
transcript
treat
Type
type I
upregulated
upregulating
virus entry
virus replication
viruses
[DOI] 10.1128/mBio.01928-20 PMC 바로가기 [Article Type] Observation
[DOI] 10.1128/mBio.01928-20 PMC 바로가기 [Article Type] Observation
Low Baseline Pulmonary Levels of Cytotoxic Lymphocytes as a Predisposing Risk Factor for Severe COVID-19
Research Article
[키워드] absence
ACE2
ACE2 expression
ACE2 gene
ACE2 mRNA
activated
acute respiratory syndrome
affected
analyses
angiotensin-converting enzyme 2
Antiviral
Asymptomatic
baseline
Bronchoalveolar lavage fluid
caused
CD8
Community
contagious
coronavirus
Coronavirus disease 2019
Coronavirus infection
coronavirus SARS-CoV-2
COVID-19
COVID-19 patient
cytokine
Cytokines
cytotoxic
data sets
detrimental
develop
effective
ENCODE
entry receptor
expression
Factor
Health
healthy individual
human cell
human lung
identify
Immune cell
immune response
Impact
IMPROVE
in silico
increase
independent
individual
infect
Infection
Inflammatory
leukocyte
leukocytes
Level
lung
lung cell
lung tissue
Lungs
lymphocyte
mild symptoms
multivariate analyses
NK cell
NK cells
Prevent
protease TMPRSS2
protein level
pulmonary
receptor
recruit
risk factor
SARS-CoV-2
SARS-CoV-2-positive individual
sensitivity
Seven
severe cases
severe COVID-19
severe COVID-19 symptoms
severe symptom
severe symptoms
significantly lower
significantly more
susceptible
T cell
T cells
the SARS-CoV-2
These cells
tissues
TMPRSS
TMPRSS2
treatment approaches
upregulation
Vaccine
virus
virus receptor
viruses
was used
[DOI] 10.1128/mSystems.00741-20 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mSystems.00741-20 PMC 바로가기 [Article Type] Research Article
Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2
Medicine
[키워드] 95% CI
95% confidence interval
ACE2
ACE2 expression
ACE2 mRNA
ACE2 protein
age
analyzed
angiotensin covering enzyme II
angiotensin-converting enzyme 2
association
Blood
Cancer
cellular entry receptor
clinical
Clinical characteristics
Coronavirus disease 2019
correlation
COVID-19
demographic
diabetes
disease
ELISA assay
enrolled
expression
Factor
female
female subject
females
form
Gender
higher risk
hypertension
identify
increased risk
individual
Infection
linear
Linear regression analysis
Logistic regression analysis
male
Multiple
Multiple linear regression
Odds ratio
Older age
older subjects
Pearson
performed
polymerase chain
questionnaire
regression analysis
reported
SARS-CoV-2
Smokers
smoking
Spread
statistically significant
student
subject
subjects
susceptibility
susceptible
t -test
was used
Wuhan, China
[DOI] 10.3389/fmed.2020.00530 PMC 바로가기 [Article Type] Medicine
[DOI] 10.3389/fmed.2020.00530 PMC 바로가기 [Article Type] Medicine
Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review
Cardiovascular Medicine
[키워드] 2019 novel coronavirus
ACE2
ACE2 mRNA
acute respiratory syndrome
Angiotensin 1-7
bind
cardiovascular damage
cardiovascular diseases
cardiovascular system
caused
cells
clinical development
clinical manifestation
coronavirus
COVID-19
develop
disease
downregulation
drug
epithelial cells
expressed
expression
Heart damage
host cell surface
hydroxychloroquine/chloroquine
interfere
Local
losartan
lung
lung alveolar
mechanism
modulate
mRNA expression
narrative
pandemic
Patient
patients with COVID-19
pulmonary damage
RAS
RAS inhibitor
RAS inhibitors
reduced
renin-angiotensin system
respiratory symptoms
responsible
review
SARS-CoV-2
System
therapy
Transmission
umifenovir
virulence
virus
[DOI] 10.3389/fcvm.2020.00143 PMC 바로가기 [Article Type] Cardiovascular Medicine
[DOI] 10.3389/fcvm.2020.00143 PMC 바로가기 [Article Type] Cardiovascular Medicine