Peripheral lymphocyte subset counts predict antibody response after SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients: Results from the Vax-On-Profile study말초 림프구 하위 집합 수는 암 환자에서 SARS-CoV-2 mRNA-BNT162b2 백신 후 항체 반응을 예측합니다: Vax-On-Profile 연구 결과Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Adaptive immune response Analysis anti-RBD Antibody Response Antibody titer Antibody titers B cell B cells Cancer cancer patient Cancer patients Chemotherapy circulating collected correlation Corticosteroid corticosteroid therapy COVID-19 COVID-19 vaccination Cytotoxic chemotherapy defined Flow cytometry analysis helper cell humoral humoral immunogenicity Humoral response IgG IgG antibodies IgG antibody IgG titer immunosuppressive indicated interactions linear correlation lymphocyte Lymphocyte subset Lymphocyte subsets mRNA Multivariate analysis Negative predictive value Occurrence Patient peripheral Peripheral blood positive positive linear correlation predict Predictive Predictive value Protein Quantitative RBD receiving Receptor-binding domain Result ROC Curve SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine seroconversion rate seroconversion rates seroconversion response serologic testing Serologically shown significantly spike Spike protein subgroups subpopulations subset symptomatic infections T helper T helper cell T helper cell. tested the receptor-binding domain the SARS-CoV-2 treated Univariate analysis vaccination efficacy Vaccine [DOI] 10.1016/j.intimp.2022.108774 PMC 바로가기 [Article Type] Article
A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Ugandaarticle Published on 2022-06-302024-09-01 Journal: Frontiers in immunology [Category] 말라리아, [키워드] Adaptive immune response antibodies Humoral immunity IgG IgM malaria memory B cells Somatic hypermutation [Article Type] article
A diminished immune response underlies age-related SARS-CoV-2 pathologies감소된 면역 반응은 연령 관련 SARS-CoV-2 병리의 기초가 됩니다Article Published on 2022-06-282022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive immune response advanced age aging B cell Bcl6 cause Ccr6 characterization Cohort Comorbidity COVID-19 CP: Immunology elevated FOXP3 hamsters host response IL-17 immune response Immunity increase in Ki67 Lungs morbidity Mortality MPO Neutralizing antibodies neutrophil Neutrophils Older pathology phenotype Post-infection reduced respiratory tract resulting SARS-CoV-2 SARS-COV-2 infection significantly Support suppressor T cells. T cell TGF-β These data tissue repair virus [DOI] 10.1016/j.celrep.2022.111002 PMC 바로가기 [Article Type] Article
High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium의료 종사자의 BNT162b2 백신 접종으로 유도된 잔류 체액 및 세포 면역에도 불구하고 우려되는 돌발 감염의 SARS-CoV-2 변종 높은 발생: 벨기에의 장기 추적 연구Clinical Trial Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Alpha analyzed antibody B cell B cells Belgium binding BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections caused CD4 CD8 Cellular immune response cellular immunity circulating concern coronavirus COVID-19 delta variant delta VoCs domain Follow-up functional healthcare healthcare worker Healthcare workers humoral immune responses immunoassays in vitro incidence individual induced initiated interferon interferon-γ investigated Long-term follow-up Long-term monitoring mitigate MONITOR neutralization not correlated performed pseudovirus reduced reported residual respiratory SARS-CoV-2 SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serology severe acute respiratory syndrome Coronavirus single-center subject symptomatic T cells Trial vaccination Vaccine-induced immunity variant variants variants of concern was determined were assessed [DOI] 10.3390/v14061257 PMC 바로가기 [Article Type] Clinical Trial
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련Article Published on 2022-06-032022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication [DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article
Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine비활성화된 SARS-CoV-2 백신으로 면역된 건강한 개인의 면역 반응과 관련된 단백질 및 대사체 서명Article Published on 2022-05-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation Adaptive immune response adaptive immune system affected Amino acid amino acids Analysis applied approach Arm Biosynthesis Cohort complement Complement activation CoronaVac COVID-19 dose driving glycine help highlight host response humoral Humoral response identify IgM/IgG immune immune response immune signature Immunity immunization immunized Inactivated vaccine individual innate immune system Interaction mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomics molecular molecular mechanism multifactorial network Phenylalanine proteomics response SARS-CoV-2 SARS-COV-2 infection Serine shown signature Sinovac specific IgM Systems biology TCA cycle threonine Tryptophan tyrosine utility vaccination Volunteer [DOI] 10.3389/fimmu.2022.848961 PMC 바로가기 [Article Type] Article
Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis BArticle Published on 2022-05-232023-06-12 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Adaptive immune response Chronic Hepatitis B entecavir functional cure innate immune response RG7854 TLR7 agonism Woodchuck [DOI] 10.3389/fimmu.2022.884113 PMC 바로가기
Trajectory patterns of SARS-CoV-2 neutralising antibody response in convalescent COVID-19 patients Research Published on 2022-05-192022-10-05 Journal: Communications Medicine [Category] 치료기술, 치료법, [키워드] Adaptive immune response Analysis association blood sample Characteristics chronic illnesses Clinical data collected contribute convalescent COVID-19 patient convalescent patient COVID-19 patient diagnosis of SARS-CoV-2 Health heterogeneity Hong Kong Infection initial laboratory data latent class neutralising antibody occur Older Patient performed Prevent Re-infection Regression model Result risk SARS-CoV-2 SARS-COV-2 infection Seroconversion subject subsequent surveillance data sVNT symptomatic symptomatic patient Symptomatic patients tested the SARS-CoV-2 trajectory Vaccination strategy Variability virus clearance Virus neutralisation were measured [DOI] 10.1038/s43856-022-00119-2 [Article Type] Research
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19Research article Published on 2022-05-142022-10-05 Journal: EClinicalMedicine [Category] 진단, 치료기술, [키워드] adaptive Adaptive immune response analyzed Antigen association Berlin cell counts cell types characterized clinical Clinical course Clinical management clone controls coronavirus coronavirus disease COVID-19 COVID-19 disease severity Critical cross-sectional decrease Disease progression disease severity distribution enrichment examined figure finding funding group healthy healthy control healthy subject heavy chain highest highlighting HLA immune Immune receptor Immune repertoires immune response Immunoglobulin IMPROVE increase in leukocyte lymphocyte measure Metadata Mild outbreak Peripheral blood Predictive Probability progression receptor SARS-CoV-2 scale sequence Sequencing severe COVID-19 severe COVID-19 disease severity subject subjects T cell T cell receptor T cells target the disease Therapies TRB TRD understanding variable with COVID-19 World Health Organization [DOI] 10.1016/j.eclinm.2022.101438 [Article Type] Research article
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review