On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite?: Experimental results and a cautionary note on challenges in translational researchShort communication Published on 2022-08-012022-10-05 Journal: Redox Biology [Category] 치료기술, [키워드] added affecting antioxidants Ascorbate Bacterial baseline Blood blood collection cardiovascular risk Cell circulating complex Concentration COVID-19 COVID-19 patient cysteine Degradation dietary habit downstream endothelial Endothelial dysfunction Experimental result fraction generate hemoglobin impair in healthy individual include Interaction maintain majority marker metabolism Nitrate nitric oxide nitrite oxidative stress oxygen Patient Premature Prevent released reported Research risk subject Thiols tissue translational uninfected vascular dysfunction [DOI] 10.1016/j.redox.2022.102362 [Article Type] Short communication
A pragmatic randomized trial of home-based testing for COVID-19 in rural Native American and Latino communities: Protocol for the “Protecting our Communities” studyArticle Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] added American Arm ARMS benefit Care Community community health Community health worker Community trial conducted COVID-19 COVID-19 test COVID-19 testing economic barrier evaluate feasibility Health health worker Home-based testing implementation Implementing lab Laboratory Latino nasal swab Native Native American outcome participant Population populations Pragmatic Protecting Randomized Randomized controlled trial randomized trial receive reduce Research SARS-CoV-2 Support The United States Trial Two-arm Washington [DOI] 10.1016/j.cct.2022.106820 PMC 바로가기 [Article Type] Article
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV Analysis Antigen antigens applied Applying approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article
Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic ReviewReview article Published on 2022-08-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] 임상, 진단, [키워드] added article clinical guideline Cochrane Library conducted Controlled trial COVID-19 COVID-19 pandemic database Dexamethasone diabetes effective End points evaluated glucocorticoid hyperglycemia Including insulin management objective Patient patients with COVID-19 RCT RCTs regimens Respiratory Support Result review Standard of care steroid Support synonym systematic review treatment strategy variety Web of Science widespread [DOI] 10.1016/j.eprac.2022.07.014 [Article Type] Review article
Stroke Family Caregiver Life Changes From the COVID-19 PandemicRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: International journal for equity in health [Category] 임상, [키워드] activities activity added affected Analysis analyzed approach assessment Care Caregiver change changes changes in conducted Consensus Controlled clinical trial COVID-19 COVID-19 pandemic Data analysis determine emotional family feasibility finding Healthcare provider indicated Internet life Masks negative negative and positive problem qualitative data Quantitative Randomized reduced resource response resulting scale selected social contact Stress stroke survivor telehealth unmet need [DOI] 10.1097/JNN.0000000000000654 PMC 바로가기 [Article Type] Randomized Controlled Trial
Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysisReview article Published on 2022-08-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] 95%CI acute infection added Case report case sery cognitive conducted COVID COVID-19 COVID-19 patient disorder Dizziness duration of follow-up eligible feature finding Frequency heterogeneity illness onset less Long COVID manifestation Medicine medRxiv Meta-analysis MOST Musculoskeletal nervous system neurologic neurological manifestation Neurological symptom NEUROLOGY objective Oxford Pain participant Patient patients with COVID-19 persistent presenting Prevalence prevalent proportion reported required sleep disorder Survivors Symptom systematic review [DOI] 10.1016/j.jiph.2022.06.013 [Article Type] Review article
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
Novel Coronavirus and Common Pneumonia Detection from CT Scans Using Deep Learning-Based Extracted Features딥 러닝 기반 추출 기능을 사용하여 CT 스캔에서 신종 코로나바이러스 및 일반적인 폐렴 감지Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy added Algorithm automatically average can be used Chest CT chest CT scan Chest CT scans China Classifier common common cold common pneumonia conditions Convolutional neural network convolutional neural network (CNN) Coronavirus pneumonia COVID-19 COVID-19 detection COVID-19 infection dataset deep deep learning deep learning features detect detection develop diagnose Diagnosis diagnostic test Extracted False-positive feature Health highest hospital Image individual infecting Intervention investigation knowledge MONITOR novel Novel coronavirus novel coronavirus pneumonia pandemic Pandemics Pneumonia Prevent reduce reported required Research severity Support support vector machine SVM Symptom Symptoms the disease the vaccine time-consuming treat Vaccine [DOI] 10.3390/v14081667 PMC 바로가기 [Article Type] Article
Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection Research Published on 2022-07-222022-10-05 Journal: Nature Communications [Category] 변종, [키워드] added administer Antibiotics Bacteria Bacterial Bacterial infection bacteriophage bone Combination European expression infecting Infection Intravenous injection joint kill Local Lytic management P. aeruginosa Patient persistence phage Pseudomonas aeruginosa purified the patient therapeutic potential therapy treat treated Treatment unique variants virus [DOI] 10.1038/s41467-022-31837-9 [Article Type] Research
Evaluation of competency-driven training for facilitators delivering a psychological intervention for children in Lebanon: a proof-of-concept studyRandomized Controlled Trial Published on 2022-07-112022-10-05 Journal: Epidemiology and Psychiatric Sciences [Category] 임상, [키워드] activity added Analysis approach assessment benefit children common competency contribute COVID-19 pandemic demonstrated distress effective delivery eliminating emotional evaluate Evidence experimental arm facilitator Factor form greater group increase in Intervention Mann-Whitney U measure mental health outcome Psychological intervention quality indicators quality of care Randomly rapid expansion recommendation reduction repeated significantly statistically significant Support task sharing. Tau Trial working [DOI] 10.1017/S2045796022000348 PMC 바로가기 [Article Type] Randomized Controlled Trial